Iridium ferrocenyl diphosphine catalyzed enantioselective reductive alkylation of a hindered aniline

Synlett

Volumn , Issue SPEC. ISS., 1999, Pages 867-868

  Blaser, Hans Ulrich ^b   Buser, Hans Peter ^a   Jalett, Hans Peter ^b   Pugin, Benoit ^b   Spindler, Felix ^b  

^a NOVARTIS PHARMA AG   (Switzerland)

^b NONE

Author keywords

(S) metolachlor; Acid catalysis; Enantioselective reductive alkylation; Hindered N alkyl aniline; Ir ferrocenyl diphosphine

Indexed keywords

2 METHYL 5 ETHYLANILINE; AMINE; ANILINE DERIVATIVE; IRIDIUM COMPLEX; IRIDIUM FERROCENYL DIPHOSPHINE; KETONE DERIVATIVE; N (2 ETHYL 6 METHYLPHENYL) N (1' METHOXYMETHYL)ETHYLAMINE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; ENANTIOMER; REACTION ANALYSIS; STEREOCHEMISTRY; STEREOSPECIFICITY; SYNTHESIS;

EID: 0033017113     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-1999-3106     Document Type: Article

References (9)

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2. Bader, R.R.; Blaser, H.U. Stud. Surf. Sci. Catal. 1997, 108, 17. Bader R.R.; Flatt, P.; Radimerski, P., EP 605363-A1 (Ciba-Geigy AG, 1992)
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4. For a case history of the discovery of the new catalyst system see Spindler, F.; Pugin, B.; Jalett, H. P.; Buser, H. P.; Pittelkow, U.; Blaser, H. U. Chem, Ind., 1996, 68, 153.
5. 6
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8. Blaser, H.U.; Pugin, B.; Spindler, F., Angew. Chem. 1990, 702, 561; Angew. Chem., Int. Ed. Engl. 1990, 29, 558. Dorta, R.; Togni, A., Organometallics 1998, 17, 3423 and 5441.
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