Randomised trial of an inhaled β2 agonist, inhaled corticosteroid and their combination in the treatment of asthma

Thorax

Volumn 54, Issue 6, 1999, Pages 482-487

  Hancox, R J ^a   Cowan, J O ^a   Flannery, E M ^a   Herbison, G P ^a   McLachlan, C R ^a   Wong, C S ^a   Taylor, D R ^a  

^a UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

Asthma; Inhaled corticosteroids; Inhaled 2 agonists

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; IPRATROPIUM BROMIDE; TERBUTALINE;

ADULT; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; HUMAN; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; MAJOR CLINICAL STUDY; PEAK EXPIRATORY FLOW; POWDER INHALER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD;

EID: 0033016895     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.54.6.482     Document Type: Article

References (19)

1. 1 Expert Panel Report No. 2. Guidelines for the diagnosis and management of asthma. Bethesda, Maryland: National Asthma Education and Prevention Program, 1997.
2. 2 British Thoracic Society, National Asthma Campaign, Royal College of Physicians of London, et al. The British guidelines on asthma management: 1995 review and position statement. Thorax 1997;52(Suppl 1):S1-21.
3. 3 Wong CS, Wahedna I, Pavord ID, et al. Effect of regular terbutaline and budesonide on bronchial reactivity to allergen challenge. Am J Respir Crit Care Med 1994;150:1268-73.
4. 2-agonist and inhaled corticosteroid on airway responsiveness to allergen and methacholine. Am J Respir Crit Care Med 1995;152:1485-9.
5. 5 Peters MJ, Adcock IM, Brown CR, et al. β-adrenoreceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung. Eur J Pharmacol 1995;289:275-81
6. 2-agonists. Eur Respir J 1996;9:160-8.
7. 7 Sears MR, Taylor DR, Print CG, et al. Regular inhaled beta agonist treatment in bronchial asthma. Lancet 1990;336: 1391-6.
8. 8 Drazen JM, Israel E, Boushey HA, et al. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. N Engl J Med 1996;335:841-7.
9. 9 Greening AP, Ind PW, Northfield M, et al. Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid. Lancet 1994; 344:219-24.
10. 10 Woolcock A, Lundback B, Ringdal N, et al. Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids. Am J Respir Crit Care Med 1996;153:1481-8.
11. 11 Pauwels RA, Löfdahl C-G, Postma DS, et al. Effect of inhaled formoterol and budesonide on exacerbations of asthma. N Engl J Med 1997;337:1405-11.
12. 12 Chai H, Farr RS, Frochlich LA, et al. Standardization of bronchial inhalation challenge procedures. J Allergy Clin Immunol 1975;56:323-7.
13. 13 Yan K, Salome C, Woolcock AJ. Rapid method for measurement of bronchial responsiveness. Thorax 1983;38:760-5.
14. 14 Taylor DR, Sears MR, Herbison GP, et al. Regular inhaled β agonist in asthma: effects on exacerbations and lung function. Thorax 1993;48:134-8.
15. 2-agonist controversy; observations, explanations and relationship to asthma epidemiology. Drug Safety 1994;11:259-83.
16. 16 Wilding PJ, Clark MM, Oborne J, et al. Effect of regular terbutaline on the airway response to inhaled budesonide. Thorax 1996;51:989-92.
17. 2-agonist and steroid dry powder inhaler in asthma. Am J Respir Crit Care Med 1995;151:1053-7.
18. 18 Bennati D, Piacentini GL, Peroni DG, et al. Changes in bronchial reactivity in asthmatic children after treatment with beclomethasone alone or in association with salbutamol. J Asthma 1989;26:359-64.
19. 19 Taylor DR, Town GI, Herbison GP, et al. Asthma control during long term treatment with regular inhaled salbutamol and salmeterol. Thorax 1998;53:744-52.