The essential role of phorbol ester-sensitive protein kinase C isoforms in activation-induced cell death of Th1 cells

European Journal of Immunology

Volumn 29, Issue 3, 1999, Pages 727-732

  Yahata, Takashi ^a   Abe, Naoko ^a   Yahata, Chie ^a   Ohmi, Yasushi ^a   Ohta, Akio ^a   Iwakabe, Kenji ^a   Habu, Sonoko ^a   Yagita, Hideo ^b   Kitamura, Hidemitsu ^a   Matsuki, Naoto ^a   Nakui, Minoru ^a   Sato, Marimo ^a   Nishimura, Takashi ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Protein kinase C; Th1; Th2

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; ISOENZYME; MONOCLONAL ANTIBODY CD3; PHORBOL 13 ACETATE 12 MYRISTATE; PHORBOL ESTER; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 0033016464     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1521-4141(199903)29:03<727::aid-immu727>3.0.co;2-0     Document Type: Article

References (15)

1. Mosmann, T. R. and Sad, S., The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 1996. 17: 138-146.
2. Ohta, A., Sato, N., Yahata, T., Ohmi, Y., Santa, K., Sato, T., Tashiro, H., Habu, S. and Nishimura, T., Manipulation of Th1/Th2 balance in vivo by adoptive transfer of antigen-specific Th1 or Th2 cells. J. Immunol. Methods 1997. 209: 85-92.
3. Nagata, S., Apoptosis by death factor. Cell 1997. 88: 355-365.
4. Ju, S. T., Panka, D. J., Cui, H., Ettinger, R., el-Khatib, M., Sheer, D. H., Stanger, B. Z. and Marshak-Rothstein, A., Fas (CD95) / FasL interactions required for programmed cell death after T-cell activation. Nature 1995. 373: 444-448.
5. Ruiz-Ruiz, M. D. C., Izquierdo, M., de Murcia, G. and Lopez-Rivas, A., Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis. Eur. J. Immunol. 1997. 27: 1442-1450.
6. Nishimura, T., Burakoff, S. J. and Herrmann, S. H., Protein kinase C required for cytotoxic T lymphocyte triggering. J. Immunol. 1987. 139: 2888-2891.
7. Ohmi, O., Ohta, A., Sasakura, Y., Sato, N., Yahata, Y., Santa, K., Habu, S. and Nishimura, T., The role of phorbol ester-sensitive protein kinase C isoforms in lymphokine-activated killer cell-mediated cytotoxicity: Dissociation between perforin-dependent and Fas-dependent cytotoxicity. Biochem. Biophys. Res. Commun. 1997. 235: 461-464.
8. Zhang, X., Brunner, T., Carter, L., Dutton, R. W., Rogers, P., Bradley, L., Sato, T., Reed, J. C., Green, D. and Swan, S. L., Unequal death in T helper cell (Th) 1 and Th2 effectors: Th1, but not Th2, undergo rapid Fas/ FasL-mediated apoptosis. J. Exp. Med. 1997. 185: 1837-1849.
9. Tsutsumi, A., Kubo, M., Fujii, H., Freire-Moar, J., Turck, C. W. and Ransom, J. T., Regulation of protein kinase C isoform proteins in phorbol ester-stimulated jurkat T lymphoma cells. J. Immunol. 1993. 150: 1746-1754.
10. Wong, B., Arron, J. and Choi, Y., T cell receptor signals enhance susceptibility to Fas-mediated apoptosis. J. Exp. Med. 1997. 186: 1939-1944.
11. Arase, H., Arase, N. and Saito, T., Fas-mediated cytotoxicity by freshly isolated natural killer cells. J. Exp. Med. 1995. 181: 1235-1238.
12. Heid, C. A., Stevens, J., Livak, K. and Williams, P. M., Real time quantitative PCR. Genome Res. 1996. 6: 986-994.
13. Cuppen, E., Nagata, S., Wieringa, B. and Hendriks, W., No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis. J. Biol. Chem. 1997. 272: 30215-30220.
14. Li-Weber, M., Laur, O., Hekele, A., Coy, J., Waiczak, H. and Krammer, P. H., A regulatory element in the CD95 (APO-1/Fas) ligand promoter is essential for responsiveness to TCR-mediated activation. Eur. J. Immunol. 1998. 28: 2373-2388.
15. lo thymocytes in vivo. Science 1990. 250: 1720-1723.