Increased concentrations of eosinophilic cationic protein in whole-gut lavage fluid from children with inflammatory bowel disease

Journal of Pediatric Gastroenterology and Nutrition

Volumn 28, Issue 2, 1999, Pages 164-168

  Troncone, Riccardo ^a,b   Caputo, Nives ^a   Esposito, Valeria ^a   Campanozzi, Angelo ^a   Campanozzi, Francesca ^a   Auricchio, Renata ^a   Greco, Luigi ^a   Cucchiara, Salvatore ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Department of Pediatrics ^*  (Italy)

Author keywords

Eosinophilic cationic protein; Eosinophils; Gut lavage; Inflammatory bowel disease; Mucosal inflammation

Indexed keywords

AZATHIOPRINE; EOSINOPHIL CATIONIC PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA; STEROID;

ADOLESCENT; ARTICLE; CHILD; CLINICAL ARTICLE; COLON CROHN DISEASE; CONTROLLED STUDY; DIAGNOSTIC APPROACH ROUTE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE MARKER; ENTERITIS; EOSINOPHIL; FEMALE; HISTOLOGY; HUMAN; INTESTINE LAVAGE; MALE; MUCOSA INFLAMMATION; PATHOGENESIS; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADOLESCENT; BLOOD PROTEINS; CHILD; COLITIS, ULCERATIVE; CROHN DISEASE; EOSINOPHIL GRANULE PROTEINS; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTESTINES; IRRIGATION; MALE; RIBONUCLEASES;

EID: 0033015094     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-199902000-00014     Document Type: Article

References (18)

1. Lowes JR, Jewel DP. The immunology of inflammatory bowel disease. Springer Semin Immunopathol 1990;12:251-68.
2. Sarin SK, Malhotra V, Sen Gupta S, Karol A, Gaur SK, Anand BS. Significance of eosinophil and mast cell counts in rectal mucosa in ulcerative colitis. Dig Dis Sci 1987;32:363-7.
3. Bischoff SC, Wedemeyer J, Herrmann A, et al. Quantitative assessment of intestinal eosinophils and mast cells in inflammatory bowel disease. Histopathology 1996;28:1-13.
4. Gleich GJ, Frigas E, Loegering DA, Wassom DL, Steinmuller D. Cytotoxic properties of the eosinophil major basic protein. J Immunol 1979;123:2925-7.
5. Motojima S, Frigas E, Loegering DA, Gleich GJ. Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro. Am Rev Respir Dis 1989;139:801-5.
6. Martin LB, Kita H, Leiferman KM, Gleich GJ. Eosinophils in allergy: Role in disease, degranulation and cytokines. Int Arch Allergy Immunol 1996;109:207-15.
7. Berstad A, Berkje B, Riedel B, Elsayed S, Berstad A. Increased fecal eosinophil cationic protein in inflammatory bowel disease. Hepatogastroenterology 1993;40:276-8.
8. O'Mahony S, Barton JR, Crichton S, Ferguson A. Appraisal of gut lavage in the study of intestinal humoral immunity. Gut 1990;31: 1341-4.
9. Ferguson A, Mwantembe O. Intestinal lavage test of gut inflammation and immunity. In: Auricchio S, Ferguson A, Troncone R, eds. Mucosal immunity and the gut epithelium: Interactions in health and disease. Basel, Switzerland: Karger 1995:1-17.
10. Troncone R, Caputo N, Campanozzi A, et al. Gut lavage IgG and interleukin 1β receptor antagonist: Interleukin 1 ratio as markers of intestinal inflammation in children with inflammatory bowel disease. Gut 1997;41:60-5.
11. Handy LM, Ghosh S, Ferguson A. Investigation of neutrophil migration into the gut by analysis of whole gut lavage fluid. Eur J Gastroenterol Hepatol 1995;7:53-8.
12. Handy LM, Ghosh S, Ferguson A. Investigation of neutrophils in the gut lumen by assay of granulocyte elastase in whole gut lavage fluid. Scand J Gastroenterol 1996;31:700-5.
13. Hyams J, Ferry GD, Mandel FS, et al. Development and validation of a pediatric Crohn's disease activity index. J Pediatr Gastroenterol Nutr 1991;12:439-47.
14. Powell-Tuck J, Bown RL, Lennard-Jones JE. A comparison of oral prednisolone given as single or multiple daily doses for active proctocolitis. Scand J Gastroenterol 1978;13:833-7.
15. Talley NJ, Kephart GM, McGovern TW, Carpenter HA, Gleich GJ. Deposition of eosinophil granular major basic protein in eosinophilic gastroenteritis and celiac disease. Gastroenterology 1992;103:137-15.
16. Majamaa H, Miettinen A, Laine S, Isolauri E. Intestinal inflammation in children with atopic eczema: Fecal eosinophil cationic protein and tumor necrosis factor-alpha as non invasive indicators of food allergy. Clin Exp Allergy 1996;26:181-7.
17. Bischoff SC, Grabowsky J, Manns MP. Quantification of inflammatory mediators in stool samples of patients with inflammatory bowel disorders and controls. Dig Dis Sci 1997;42:394-403.
18. Ferguson A, Humphreys KA, Croft NM. Technical report: Results of immunological tests on faecal extracts are likely to be extremely misleading. Clin Exp Immunol 1995;99:70-5.