A review of the effects of microgravity and of hypergravity on aging and longevity

Experimental Gerontology

Volumn 34, Issue 3, 1999, Pages 319-336

  Le Bourg, Eric ^a  

^a CNRS   (France)

Author keywords

Aging; Hypergravity; Longevity; Microgravity

Indexed keywords

AGING; BODY WEIGHT; DROSOPHILA MELANOGASTER; FEMALE; GRAVITY; LIFESPAN; LOCOMOTION; LONGEVITY; MALE; METABOLIC RATE; MICROGRAVITY; MOTOR COORDINATION; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPACE FLIGHT;

COSMOS 782 PROJECT; COSMOS 936 PROJECT; FLIGHT EXPERIMENT; MANNED; PARABOLIC FLIGHT; SHORT DURATION; STS SHUTTLE PROJECT; UNMANNED;

AGING; ANIMALS; DROSOPHILA MELANOGASTER; FEMALE; HUMANS; HYPERGRAVITY; LONGEVITY; MALE; SPACE FLIGHT; WEIGHTLESSNESS; WEIGHTLESSNESS SIMULATION;

DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER;

EID: 0033015084     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00004-2     Document Type: Review

References (50)

1. Benguria A., Grande E., De Juan E. Microgravity effects on Drosophila melanogaster behavior and aging. Implications of the IML-2 experiment. J Biotechnol. 47:1996;191-201.
2. Bilcik B., Boda K., Kostal L., Sykora J., Jurani M., Sabo V. Behavioural adaptation of Japanese quail to the repeated short-term microgravity induced by parabolic flights. Acta Vet Brno. 65:1996;73-75.
3. Bücker H., Facius R., Horneck G. Embryogenesis and organogenesis of Carausius morosus under spaceflight conditions. Adv Space Res. 6:1986;115-124.
4. Connolly K. Locomotor activity in Drosophila III. A distinction between activity and reactivity. Anim Behav. 15:1967;149-152.
5. Daligcon B.C., Oyama J. Increased uptake and utilization of glucose by diaphragms of rats exposed to chronic centrifugation. Am J Physiol. 228:1975;42-46.
6. Economos, A. C. (1978). Space gerontology: Altered gravity as a gerontological research tool. Communication at the 31st Annual Meeting of the Gerontological Society. Dallas, TX.
7. Economos, A. C. (1982). Human homeostasis in the space environment: a systems synthesis approach. In J. Miquel & A.C. Economos (Eds.). Space Gerontology. NASA Conference Publication 2248 (pp. 13-35) Washington D.C.
8. Economos A.C., Miquel J., Ballard R.C. Effects of simulated increased gravity on the rate of aging of rats Implications for the rate of living theory . Arch Gerontol Geriatr. 1:1982;349-363.
9. Ewing A.W. Attempts to select for spontaneous activity in Drosophila melanogaster. Anim Behav. 11:1963;369-378.
10. Frolkis V.V. Stress-age syndrome. Mech Ageing Dev. 69:1993;93-107.
11. Hemmersbach-Krause R., Briegleb W., Häder D.P., Vogel K., Grothe D., Meyer I. Orientation of Paramecium under the conditions of weightlessness. J Eukaryot Microbiol. 40:1993;439-446.
12. Khazaeli A.A., Tatar M., Pletcher S.D., Curtsinger J.W. Heat-induced longevity extension in Drosophila. Heat treatment, mortality, and thermotolerance. J Geront Biol Sci. 52A:1997;B48-B52.
13. Le Bourg E. Hypergravity and aging in Drosophila melanogaster. 8. Proboscis-extension-response to sucrose. Gerontology. 42:1996;235-240.
14. Le Bourg E., Grimal A., Fresquet N., Lints F.A. Spontaneous locomotor activity of Drosophila melanogaster flies at various gravity levels (0 g, 1 g, 1.8 g) during parabolic flights. Behav Proc. 34:1995;75-184.
15. Le Bourg E., Lints F.A. Hypergravity and ageing in Drosophila melanogaster. 2. Longevity. Gerontology. 35:1989;244-252.
16. Le Bourg E., Lints F.A. Hypergravity and aging in Drosophila melanogaster. 4. Climbing activity. Gerontology. 38:1992;59-64.
17. Le Bourg E., Lints F.A. Hypergravity and aging in Drosophila melanogaster. 5. Patterns of movement. Gerontology. 38:1992;65-70.
18. Le Bourg E., Lints F.A. Hypergravity and aging in Drosophila melanogaster. 6. Spontaneous locomotor activity. Gerontology. 38:1992;71-79.
19. Le Bourg E., Minois N. Increased longevity and resistance to heat shock in Drosophila melanogaster flies exposed to hypergravity. C R Acad Sci Paris. 320:1997;215-221.
20. Le Bourg E., Minois N. A mild stress, hypergravity exposure, postpones behavioral aging in Drosophila melanogaster. Exp Geront. 34:1999;000-000.
21. Lee R.E., Bryant E.H., Baust J.G. Fecundity and longevity of houseflies after space flight. Experientia. 41:1985;1191-1192.
22. Lints F.A., Bullens P., Le Bourg E. Hypergravity and aging in Drosophila melanogaster. 7. New longevity data. Exp Geront. 28:1993;611-615.
23. Lints F.A., Le Bourg E. Hypergravity and ageing in Drosophila melanogaster. 7. Fecundity. Gerontology. 35:1989;235-243.
24. Marco R., Vernos I., Gonzalez J., Calleja M. Embryogenesis and aging of Drosophila melanogaster flown in the space shuttle. Naturwiss. 73:1986;431-432.
25. Minois N., Le Bourg E. Hypergravity and aging in Drosophila melanogaster. 9. Conditioned suppression and habituation of the proboscis extension response. Aging Clin Exp Res. 9:1997;281-291.
26. Miquel, J. (1982). Comparison between the weightlessness syndrome and aging. In J. Miquel & A.C. Economos (Eds.). Space Gerontology, NASA Conference Publication 2248 (pp. 1-7).
27. Miquel, J. (1984). Effects of microgravity and hypergravity on invertebrate development. In K. A. Souza & T. W. Halstead (Eds.). NASA Developmental Biology Workshop. NASA Technical Memorandum 86756 (pp. 7-34). Arlington, Virginia, May 1984.
28. Miquel, J. & Economos, A. C. (1982). Preface. In J. Miquel & A.C. Economos (Eds.). Space Gerontology, NASA Conference Publication 2248 (p. vii).
29. Miquel, J. & Philpott, D. E. (1978). Effects of weightlessness on the genetics and aging of Drosophila melanogaster. In S. N. Rosenzweig & K. A. Souza (Eds.). Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 936. NASA Technical Memorandum 78526 (pp. 32-54).
30. Miquel, J., Philpott, D. E., Lundgren, P. R., Binnard, R., & Turnbill, C. E. (1978). Effects of weightlessness on the embryonic development and aging of Drosophila. In S. N. Rosenzweig & K. A. Souza (Eds.). Final Reports of U.S. Experiments Flown on the Soviet Satellite Cosmos 782. NASA Technical Memorandum 78525 (pp. 382-404).
31. Miquel J., Souza K.A. Gravity effects on reproduction, development, and aging. Adv Space Biol Med. 1:1991;71-97.
32. Mohler S.R. Age and space flight. Aviat Space Environ Med. 56:1985;714-717.
33. Mooradian K.K., Timchenko A.N. Effects of hypergravity stress on gaseous exchange, thermoregulation, and survival of rats of different ages [in Russian]. Problems Aging Long (Kiev). 6:1996;11-16.
34. Oyama, J. (1971). Hypergravity and aging in animals. In Proceedings from the First Rocky Mountain Symposium on Aging.
35. Oyama J. Effects of altered gravitational fields on laboratory animals. Prog Anim Biometeorol. 1:1976;793-808.
36. Oyama, J. (1982). Metabolic effects of hypergravity on experimental animals. In J. Miquel & A.C. Economos (Eds.). Space Gerontology. NASA Conference Publication 2248 (pp. 37-51).
37. Oyama J., Chen L. Oxygen consumption and carbon dioxide production in rats during acute centrifugation stress and after adaptation to chronic centrifugation. Fed Proc. 32:1973;392.
38. Pearl R. The Rate of Living. 1928;University of London Press, London.
39. Pearl R., Allen L., Pennimann W.B.D. Culture media for Drosophila II. A new synthetic medium and its influence on fertility at different densities of population. Am. Natur. 60:1926;357-366.
40. Pitts G.C., Bull L.S., Oyama J. Effect of chronic centrifugation on body composition in the rat. Am J Physiol. 223:1972;1044-1048.
41. Pitts G.C., Bull L.S., Oyama J. Regulation of body mass in rats exposed to chronic acceleration. Am J Physiol. 228:1975;714-717.
42. Planel H. L'Espace et la Vie. 1988;Larousse, Paris.
43. Serova L.V., Denisova L.A., Pustynnikova A.M. Comparative analysis of hypo- and hyper-gravity effects on prenatal development of mammals. The Physiologist. 28:1985;S5-S8.
44. Skidmore R., Gutteriez J.A., Guerriero V., Kregel K.C. HSP70 induction during exercise and heat stress in rats Role of internal temperature . Am J Physiol. 268:1995;R92-R97.
45. Sondag H.N.P.M., De Jong H.A.A., Oosterveld W.J. Altered behaviour of hamsters by prolonged hypergravity Adaptation to 2.5 g and readaptation to 1 g . Acta Otolaryngol (Stockh). 116:1996;192-197.
46. Souza K.A., Black S.D., Wassersug R.J. Amphibian development in the virtual absence of gravity. Proc Natl Acad Sci USA. 92:1995;1975-1978.
47. Thornling E.B., Fredens K. The influence of small changes in the gravitational field on the weight regulation in the female Wistar rats. Intl J Obes. 19:1995;305-309.
48. Vernos, I., Gonzalez-Jurado, J., Calleja, M., Carratala, M., & Marco, R. (1988). Effects of short spaceflights on Drosophila melanogaster embryogenesis and life span. In N. Longdon & V. David (Eds.). Biorack on Spacelab D1 (pp. 121133). Noordwijk, The Netherlands: ESA Publication Division ESTEC, ESA-SP 1091.
49. Wassersug R., Izumi-Kurotani A. The behavioral adaptations of a snake and a turtle to abrupt decreases in gravity. Zool Sci. 10:1993;505-509.
50. Wunder C.C. Gravitational aspects of growth as demonstrated by continual centrifugation of the common fruit fly larvae. Proc Soc Exptl Biol Med. 89:1955;544-546.