Intra-hippocampal KN-62 hinders the memory of habituation acquired alone, but not simultaneously with a water-finding task

Behavioural Pharmacology

Volumn 10, Issue 1, 1999, Pages 99-104

  Wolfman, C ^a   Izquierdo, L A ^b   Schroder N ^b   Izquierdo, I ^b  

^a Facultad de Medicina   (Argentina)

^b FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Calcium calmodulin dependent protein kinase II; Habituation learning; KN 62; Rat; Water finding learning

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; ISOQUINOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; HABITUATION; HIPPOCAMPUS; MALE; MEMORY; NONHUMAN; RAT;

EID: 0033014749     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199902000-00009     Document Type: Article

References (15)

1. Barria A, Muller D, Derkach V, Griffith LC, Soderling, T.R. (1997). Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation. Science 276:2042-2045.
2. Baddeley A (1986). Working Memory. London: Oxford University Press.
3. 2+/calmodulin-dependent protein kinase II activity and AMPA GluR1 subunit immunoreactivity. Eur J Neurosci 10:2669-2676.
4. Izquierdo I, Medina JH (1997). Memory formation: The sequence of biochemical events in the hippocampus and its connection to activity in other brain structures. Neurobiol Learn Mem 68:285-316.
5. Izquierdo LA, Schröder N, Ardenghi P, Quevedo J, Bevilaqua L, Netto CA, Izquierdo I, Medina, JH (1997). Systemic administration of ACTH or vasopressin in rats reverses the amnestic effect of post-training β-endorphin but not that of intra-hippocampal infusion of protein kinase inhibitors. Neurobiol Learn Mem 68:197-202.
6. Izquierdo I, Izquierdo LA, Barros DM, Mello e Souza T, de Souza MM, Quevedo J, Rodrigues C, Kauer Sant'Anna M, Madruga M, Medina JH (1998). Differential involvement of cortical receptor mechanisms in working, short-and long-term memory. Behav Pharmacol (in press).
7. Le Moal M, Dantzer R, Mormède P, Baduel A, Lebrun C, Ettenberg A, van der Kooy D, Wenger J, Deyo S, Koob GF, Bloom FE (1984). Behavioral effect of peripheral administration of arginine vasopressin: a review of our search for a mode of action and a hypothesis. Psychoneuroendocrinology 9:319-341.
8. Mayford M, Bach ME, Huang Y-Y, Wang L, Hawkins RD, Kandel ER (1996). Control of memory formation through regulation of a CaMKII transgene. Science 274:1678-1683.
9. Netto CA, Dias RD, Izquierdo I (1986). Differential effect of post-training naloxone, β-endorphin, leu-enkephalin and electroconvulsive shock administration upon memory of an open-field habituation and of a water-finding task. Psychoneuroendocrinology 11:437-446.
10. Novas ML, Wolfman C, Medina JH, De Robertis E (1988). Proconvulsant and 'anxiogenic' effects of n-butyl beta-carboline-3-carboxylate, a potent benzodiazepine-binding inhibitor. Pharmacol Biochem Behav 30:331-336.
11. Paxinos G, Watson C (1986). The Rat Brain in Stereotaxic Coordinates. (2nd ed.). San Diego, CA: Academic Press.
12. Skaggs WE, McNaughton BL (1996). Replay of neuronal firing sequences during sleep following spatial experience. Science 271:1870-1873.
13. Tan S-E, Liang KC (1996). Spatial learning alters calcium/ calmodulin-dependent protein kinase II in rats. Brain Res 711:234-240.
14. Tenen SS (1965). Retrograde amnesia from electroconvulsive shock in a one-trial appetitive learning task. Science 148: 1248-1250.
15. Wolfman C, Fin C, Dias M, Bianchin M, Da Silva RC, Schmitz PK, Medina JH, Izquierdo I (1994) Intra-hippocampal or intra-amygdala infusion of KN62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, causes retrograde amnesia in the rat. Behav Neural Biol 61:203-205.