The structure of major birch pollen allergens - Epitopes, reactivity and cross-reactivity

Allergy: European Journal of Allergy and Clinical Immunology, Supplement

Volumn 54, Issue 50, 1999, Pages 23-26

  Spangfort, Michael D ^a   Mirza, Osman ^a,b   Holm, Jens ^a   Larsen, Jørgen N ^a   Ipsen, Henrik ^a   Løwenstein, Henning ^a   Gaihede, Michael ^b  

^a ALK ABELLÓ   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; EPITOPE; POLLEN ANTIGEN;

ALPHA HELIX; AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ANTIGEN BINDING; B LYMPHOCYTE; CHEMICAL STRUCTURE; CONFERENCE PAPER; CROSS REACTION; EPITOPE MAPPING; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS; TREE;

ALLERGENS; ANIMALS; ANTIBODIES, MONOCLONAL; CROSS REACTIONS; EPITOPES; MICE; PLANT PROTEINS; POINT MUTATION; POLLEN; PROTEIN CONFORMATION; TREES; X-RAY DIFFRACTION;

EID: 0033014290     PISSN: 01081675     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (5)

1. Gajhede M, Osmark P, Poulsen FM, Ipsen H, Larsen JN, van Neerven RJJ, Schou C, Løwenstein H, Spangfort MD, X-ray and NMR structure of Bet v 1, the origin of birch pollen allergy. Nature Struct Biol 1996;3:1040-1045.
2. Ipsen H, Wihl J-Å, Nüchel Petersen B, Løwenstein H. Specificity mapping of patients IgE response towards the tree pollen allergens Aln g I, Bet v I and Cor a I. Clin Exp Allergy 1992;22:391-399.
3. Davies DR, Padlan EA, Sheriff S. Antibody-antigen complexes. Annu Rev Biochem 1990;59:439-473.
4. Spangfort MD, Mirza O, Svensson LA, Larsen JN, Gajhede M, Ipsen H. Crystallization and preliminary X-ray analysis of birch pollen allergen Bet v 1 in complex with a murine monoclonal Fab' that inhibits binding of human specific serum IgE (submitted)..
5. Mirza O, Henriksen A, Ipsen H, Larsen JN, Wissenbach M, Spangfort MD, Gajhede M. Dominant epitopes and allergic cross-reactivity: Complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1 (submitted)..