Novel therapies for ethylene glycol intoxication

Current Opinion in Pediatrics

Volumn 11, Issue 3, 1999, Pages 269-273

  Wiley II, James F ^a,b  

^a UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

^b Farmington   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ANTIDOTE; ETHYLENE GLYCOL; PYRIDOXINE; THIAMINE;

HUMAN; INTOXICATION; PRIORITY JOURNAL; REVIEW;

ANTIDOTES; CHILD; DECONTAMINATION; ETHYLENE GLYCOL; HUMANS; POISONING; PYRAZOLES; RENAL DIALYSIS;

EID: 0033013995     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008480-199906000-00019     Document Type: Review

References (25)

1. 1 Litovitz TL, Smilkstein M, Felberg L, Klein-Schwartz W, Berlin R, Morgan JL: 1996 Annual report of the American Association of Poison Control Centers. Am J Emerg Med 1997, 15:447-500.
2. 2 Baud FJ, Galliot M, Astier A, Dang VB, Garnier R, Likforman J, Bismuth C: Treatment of ethylene glycol poisoning with intravenous 4-methylpyrazole. N Engl J Med 1988, 319:97-100.
3. 3 Jacobsen D, Sebastian CS, Blomstrand R, McMartin KE: 4-Methylpyrazole: a controlled study of safety in healthy human subjects after single, ascending doses. Alcohol Clin Exp Res 1988, 12:516-522.
4. 4 Jacobsen D, Sebastian CS, Barron SK, Carriere EW, McMartin KE: Effects of 4-methylpyrazole, methanol/ethylene glycol antidote in healthy humans. J Emerg Med 1990, 8:455-461.
5. 5 Jobard E, Harry P, Turcant A, Roy PM, Allain P: 4-Methylpyrazole and hemodialysis in ethylene glycol poisoning. J Toxicol Clin Toxicol 1996, 34:373-377.
6. 6 Shannon M: Toxicology reviews: Fomepizole - a new antidote. Pediatr Emerg Care 1998, 14:170-172. This is an excellent review of fomepizole and its role in the treatment of ethylene gtycol poisoning.
7. 7 Jacobsen D, McMartin KE: Antidotes for methanol and ethylene glycol poisoning. J Toxicol Clin Toxicol 1997, 35:127-143. This is a superb overview of the state-of-the-art regarding current therapy of toxic alcohol exposures with suggestions for future study. Fomepizole treatment is covered briefly.
8. 8 Brent J: Antidotes and alcohols: has fomepizole made ethanol an obsolete therapy? The Internet Journal of Medical Toxicology [serial online] 1998, 1:2a. Available at: http://www.homepage.org/ijmtdesc.htm. Accessed Februrary 25, 1998. Brent, one of the chief investigators from the US multicenter fomepizole trial, discusses the relative risks and benefits of fomepizole versus ethanol administration in toxic alcohol poisoning. (This reference is available only in electronic form.)
9. 9 Harry P, Jobard E, Briand M, Caubet A, Turcant A: Ethylene glycol poisoning in a child treated with 4-methylpyrazole. Pediatrics [serial online] 1998, 102:31. Available at: http://www.pediatrics.org. Accessed September, 1998. This article describes the first reported use of fomepizole in treating pediatric ethylene glycol poisoning and provides excellent clinical and pharmacokinetic information. (Abstract is available in printed form; entire article is available only in electronic form.)
10. 10 Winter ML, Ellis MD, Snodgrass WR: Urine fluorescence using a Wood's lamp to detect the antifreeze additive sodium fluorescein: a qualitative adjunctive test in suspected ethylene glycol ingestions. Ann Emerg Med 1990, 19:663-667.
11. 11 Aarstad K, Dale O, Aakervik, Ovrebo S, Zahlsen K: A rapid gas chromatographic method for determination of ethylene glycol in serum and urine. J Anal Toxicol 1993, 17:218-221.
12. 12 Saladino R, Shannon M: Accidental and intentional poisonings with ethylene glycol in infancy: diagnostic clues and management. Pediatr Emerg Care 1991, 7:93-96.
13. 13 Burkhart KK, Martinez MA: The adsorption of isopropanol and acetone by activated charcoal. J Toxicol Clin Toxicol 1992, 30:371-375.
14. 14 Decker WJ, Corby DCT, Hilburn RE, Lynch RE: Adsorption of solvents by activated charcoal, polymers and mineral sorbents. Vet Hum Toxicol 1981, 235:44-46.
15. 15 Roe O: Methanol poisoning: its clinical course, pathogenesis and treatment. Acta Med Scand 1946, 126:1-253.
16. 16 Tarr B, Winters L, Moore M, Cowell RL, Hayton WL: Low dose ethanol in the treatment of ethylene glycol poisoning. J Vet Pharmacol Ther 1985, 8:254-262.
17. 17 Rothman A, Sven A, Manoguerra AS, Bastian JF, Griswold WR: Short-term hemodialysis in childhood ethylene glycol poisoning. J Pediatr 1986, 108:153-155.
18. 18 Peterson C, Collins A, Himes JM, Bullock ML, Keane WF: Ethylene glycol poisoning: pharmacokinetics during therapy with ethanol and hemodialysis. N Engl J Med 1981, 304:21-23.
19. 19 Mundy RL, Hall LM, Teague RS: Pyrazole as an antidote for ethylene glycol poisoning. Toxicol Appl Pharmacol 1974, 28:320-322.
20. 20 Clay KL, Murphy RC: On the metabolic acidosis of ethylene glycol intoxication. Toxicol Appl Pharmacol 1977, 39:39-49.
21. 21 Jacobsen D, Barron SK, Sebastian CS, Blomstrand R, McMartin KE: Nonlinear kinetics of 4-methylpyrazole in healthy human subjects. Eur J Clin Pharmacol 1989, 37:599-604.
22. 22 Baud FJ, Bismuth C, Garnier R, Galliot M, Astier A, Maistre G, Soffer M: 4-Methylpyrazole may be an alternative to ethanol therapy for ethylene glycol intoxication in man. Clin Toxicol 1987, 24:463-483.
23. 23 Beasley UR, Buck WB: Acute ethylene glycol toxicosis: a review. Vet Hum Toxicol 1980, 22:255-263.
24. 24 Hannet B, Thomas DW, Chalmers AH, Rofe AM, Edwards JB, Edwards RG: Formation of oxalate in pyridoxine or thiamine deficient rats during intravenous xylitol infusions. J Nutr 1977, 107:458-465.
25. 25 Jacobsen D, Ovrebo S, Ostborg J, Sejersted OM: Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med Scand 1984, 216:409-416.