Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters

Regulatory Toxicology and Pharmacology

Volumn 29, Issue 2 I, 1999, Pages 205-210

  Turnbull, Duncan ^a   Frankos, Vasilios H ^a   Van Delft, J H M ^b   DeVogel, N ^b  

^a ENVIRON INTERNATIONAL CORPORATION   (United States)

^b TNO   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID ESTER; VEGETABLE OIL;

ARTICLE; CHEMICAL STRUCTURE; CHROMOSOME ABERRATION; FOOD SAFETY; GENE MUTATION; GENOTOXICITY; MAMMAL CELL; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; WOOD;

BACTERIA (MICROORGANISMS); MAMMALIA; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0033013981     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.1999.1289     Document Type: Article

References (6)

1. Ames, B. N., McCann, J., and Yamasaki, E. (1975). Methods for detecting carcinogens and mutagens with the Salmonella/mammalian microsome mutagenicity test. Mutat. Res. 31, 347-365.
2. Cole, J., Arlett, C. F., Green, M. H. L., Lowe, J., and Muriel, W. (1983). A comparison of the agar cloning and microtitration techniques for assessing cell survival and mutation frequency in L5178Y mouse lymphoma cells. Mutat. Res. 111, 371-386.
3. Heinemann, T., Kullak-Ublick, G.-A., Pitruck, B., and von Bergmann, K. (1991). Mechanisms of action of plant sterols on inhibition of cholesterol absorption: Comparison of sitosterol and sitostanol. Eur. J. Clin. Pharmacol. 40(Suppl. 1), S59-S63.
4. Maron, D. M., and Ames, B. N. (1983). Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173-215.
5. Miettinen, T. A., Puska, P., Gylling, H., Vanhannen, H., and Vartiainen, E. (1995). Reduction of serum cholesterol with sitostanolester margarine in a mildly hypercholesterolemic population. New Engl. J. Med. 333, 1308-1312.
6. Sugano, M., Morioka, H., and Ikeda, I. (1977). A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. J. Nutr. 107, 2011-2019.