Infantile autism and associated autosomal chromosome abnormalities: A register-based study and a literature survey

Journal of Child Psychology and Psychiatry and Allied Disciplines

Volumn 40, Issue 3, 1999, Pages 335-345

  Lauritsen, Marlene B ^a   Mors, O ^a   Mortensen, P B ^a   Ewald, H ^a  

^a NONE

Author keywords

Autism; Chromosomes; Genetics

Indexed keywords

ARTICLE; AUTOSOMAL DISORDER; CHROMOSOME 10Q; CHROMOSOME 15Q; CHROMOSOME 16Q; CHROMOSOME 17Q; CHROMOSOME 7Q; CHROMOSOME ABERRATION; CYTOGENETICS; DENMARK; FAMILY; FEMALE; GENE LOCUS; GENETIC LINKAGE; HUMAN; INFANTILE AUTISM; LITERATURE; MALE; PHENOTYPE; REGISTER; TWINS;

ADULT; AUTISTIC DISORDER; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOME DISORDERS; COMORBIDITY; DATABASES, FACTUAL; DENMARK; FAMILY HEALTH; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; KARYOTYPING; MALE; MEDICAL RECORD LINKAGE; PEDIGREE; REGISTRIES;

EID: 0033013602     PISSN: 00219630     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0021963098003710     Document Type: Article

References (98)

1. American Psychiatric Association. (1980). Diagnostic and statistical manual of mental disorders (3rd ed., DSM-III). Washington, DC: Author.
2. American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed.-revised, DSM-III-R). Washington, DC: Author.
3. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed., DSM-IV). Washington, DC: Author.
4. Arrieta, I., Lobato, M. N., Martinez, B., & Criado, B. (1994). Parental origin of Robertsonian translocation (15q22q) and Prader Willi syndrome associated with autism [letter]. Psychiatric Genetics, 4, 63-65.
5. August, G. J., Stewart, M. A., & Tsai, L. (1981). The incidence of cognitive disabilities in the siblings of autistic children. British Journal of Psychiatry, 138, 416-422.
6. Bailey, A., Bolton, P., Butler, L., Le Couteur, A., Murphy, M., Scott, S., Webb, T., & Rutter, M. (1993). Prevalence of the fragile X anomaly amongst autistic twins and singletons. Journal of Child Psychology ami Psychiatry, 34, 673-688.
7. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, E., & Rutter, M. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63-77.
8. Bailey, A., Phillips, W., & Rutter, M. (1996). Autism: Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. Journal of Child Psychology and Psychiatry, 37, 89-126.
9. Baird, T. D., & August, G. J. (1985). Familial heterogeneity in infantile autism. Journal of Autism and Developmental Disorders, 15, 315-321.
10. Baker, P., Piven, J., Schwartz, S., & Patil, S. (1994). Brief report: Duplication of chromosome 15q11-13 in two individuals with autistic disorder. Journal of Autism and Developmental Disorders, 24, 529-535.
11. Barber, J. C., Ellis, K. H., Bowles, L. V., Delhanty, J. D., Ede, R. F., Male, B. M., & Eccles, D. M. (1994). Adenomatous polyposis coli and a cytogenetic deletion of chromosome 5 resulting from a maternal intrachromosomal insertion. Journal of Medical Genetics, 31, 312-316.
12. Bolton, P., Macdonald, H., Pickles, A., Rios, P., Goode, S., Crowson, M., Bailey, A., & Rutter, M. (1994). A case-control family history study of autism. Journal of Child Psychology and Psychiatry, 35, 877-900.
13. Bolton, P., Powell, J., Rutter, M., Buckle, V., Yates, J. R. W., Ishikawa-Brush, Y., & Monaco, A. P. (1995). Autism, mental retardation, multiple exostoses and short stature in a female with 46, X, t(X; 8) (p22.13; q22.1). Psychiatric Genetics, 5, 51-55.
14. Bottani, A., Xie, Y. G., Binkert, F., & Schinzel, A. (1991). A case of Hirschsprung disease with a chromosome 13 microdeletion, del(13) (q32.3q33.2): Potential mapping of one disease locus. Human Genetics, 87, 748-750.
15. Bregman, J. D., & Volkmar, F. R. (1988). Autistic social dysfunction and Down syndrome. Journal of the American Academy of Child and Adolescent Psychiatry, 27, 440-441.
16. Bundey, S., Hardy, C., Vickers, S., Kilpatrick, M. W., & Corbett, J. A. (1994). Duplication of the 15q11-13 region in a patient with autism, epilepsy and ataxia. Developmental Medicine and Child Neurology, 36, 736-742.
17. Burd, L., Kerbeshian, J., Fisher, W., & Martsolf, J. T. (1985). A case of autism and mosaic of trisomy 8 [letter]. Journal of Autism and Developmental Disorders, 15, 351-352.
18. Burd, L., Martsolf, J. T., Kerbeshian, J., & Jalal, S. M. (1988). Partial 6p trisomy associated with infantile autism. Clinical Genetics, 33, 356-359.
19. Cabral de Almeida, J. C., Reis, D. F., & Martins, R. R. (1989). Interstitial deletion of (17) (p11.2). A microdeletion syndrome. Another example. Annals of Genetics, 32, 184-186.
20. Cantu, E. S., Stone, J. W., Wing, A. A., Langee, H. R., & Williams, C. A. (1990). Cytogenetic survey for autistic fragile X carriers in a mental retardation center. American Journal of Mental Retardation, 94, 442-447.
21. Chodirker, B. N., Chudley, A. E., Ray, M., Wickstrom, D. E., & Riordan, D. L. (1987). Fragile 19p13 in a family with mental illness. Clinical Genetics, 31, 1-6.
22. Comings, D. E., Comings, B. G., Muhleman, D., Dietz, G., Shahbahrami, B., Tast, D., Knell, E., Kocsis, P., Baumgarten, R., Kovacs, B. W., et al. (1991). The dopamine D2 receptor locus as a modifying gene in neuropsychiatric disorders [see comments]. JAMA, 266, 1793-1800.
23. Cook, E. H. Jr., Courchesne, R., Lord, C., Cox, N. J., Yan, S., Lincoln, A., Haas, R., Courchesne, E., & Leventhal, B. L. (1997). Evidence of linkage between the serotonin transporter and autistic disorder. Molecular Psychiatry, 2, 247-250.
24. Cook, E. H. Jr., Lindgren, V., Leventhal, B. L., Courchesne, R., Lincoln, A., Shulman, C., Lord, C., & Courchesne, E. (1997). Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. American Journal of Human Genetics, 60, 928-934.
25. Daniels, W. W., Warren, R. P., Odell, J. D., Maciulis, A., Burger, R. A., Warren, W. L.. & Torres, A. R. (1995). Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism. Neuropsychobiology, 32, 120-123.
26. Fahsold, R., Rott, H. D., Claussen, U., & Schmalenberger, B. (1991). Tuberous sclerosis in a child with de novo translocation t(3; 12) (p26.3; q23.3). Clinical Genetics, 40, 326-328.
27. Flejter, W. L., Bennett-Baker, P. E., Ghaziuddin, M., McDonald, M., Sheldon, S., & Gorski, J. L. (1996). Cytogenetic and molecular analysis of inv dup(15) chromosomes observed in two patients with autistic disorder and mental retardation. American Journal of Medical Genetics, 61, 182-187.
28. Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297-321.
29. Fryns, J., & Kleczkowska, A. (1992). Autism and ring chromosome 18 mosaicism [2]. Clinical Genetics, 55.
30. Gelernter, J., Rao, P. A., Pauls, D. L., Hamblin, M. W., Sibley, D. R., & Kidd. K. K. (1995). Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics, 26, 207-209.
31. Ghaziuddin, M. (1997). Autism in Down's syndrome: Family history correlates. Journal of Intellectual Disability Research, 41, 87-91.
32. Ghaziuddin, M., Sheldon, S., Tsai, L. Y., & Alessi, N. (1993). Abnormalities of chromosome 18 in a girl with mental retardation and autistic disorder. Journal of Intellectual Disability Research, 37, 313-317.
33. Gillberg, C., & Coleman, M. (1996). Autism and medical disorders: A review of the literature. Developmental Medicine and Child Neurology, 38, 191-202.
34. Gillberg, C., Steffenburg, S., Wahlström, J., Gillberg, I. C., Sjostedt, A., Martinsson, T., Liedgren, S., & Eeg Olofsson, O. (1991). Autism associated with marker chromosome. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 489-494.
35. Gillberg, C., & Wahlström, J. (1975). Chromosome abnormalities in infantile autism and other childhood psychoses: A population study of 66 cases. Developmental Medicine and Child Neurology, 27, 293-304.
36. Greenberg, F., Guzzetta, V., Montes de Oca-Luna, R., Magenis, R. E., Smith, A. C. M., Richter, S. F., Kondo, I., Dobyns, W. B., Patel, P. I., & Lupski, J. R. (1991). Molecular analysis of the Smith-Magenis syndrome: A possible contiguous-gene syndrome associated with del(17) (p11.2). American Journal of Human Genetics, 49, 1207-1218.
37. Gurling, H. M., Bolton, P. F., Vincent, J., Melmer, G., & Rutter, M. (1997). Molecular and cytogenetic investigations of the fragile X region including the Frax A and Frax E CGG trinucleotide repeat sequences in families multiplex for autism and related phenotypes. Human Heredity, 47, 254-262.
38. Hagerman, R. (1989). Chromosomes, genes and autism. In C. Gillberg (Ed.), Diagnosis and treatment of autism (pp. 105-131). New York: Plenum Press.
39. Halal, F., Vekemans, M., Kaplan, P., & Zeesman, S. (1990). Distal deletion of chromosome 1q in an adult. American Journal of Medical Genetics, 35, 379-382.
40. Hansen, A., Brask, B. H., Nielsen, J., Rasmussen, K., & Sillesen, I. (1977). A case report of an autistic girl with an extra bisatellited marker chromosome. Journal of Autism and Childhood Schizophrenia, 7, 263-267.
41. Hebebrand, J., Martin, M., Korner, J., Roitzheim, B., de Braganca, K., Werner, W., & Remschmidt, H. (1994). Partial trisomy 16p in an adolescent with autistic disorder and Tourette's syndrome. American Journal of Medical Genetics, 54, 268-270.
42. Herault, J., Martineau, J., Petit, E., Perrot, A., Sauvage, D., Barthelemy, C., Mallet, J., Muh, J. P., & Lelord, G. (1994). Genetic markers in autism: Association study on short arm of chromosome 11 [letter]. Journal of Autism and Developmental Disorders, 24, 233-236.
43. Herault, J., Perrot, A., Barthelemy, C., Buchler, M., Cherpi, C., Leboyer, M., Sauvage, D., Lelord, G., Mallet, J., & Muh, J. (1993). Possible association of C-Harvey-Ras-1 (HRAS-1) marker with autism. Psychiatry Research, 46, 261-267.
44. Herault, J., Petit, E., Buchler, M., Martineau, J., Cherpi, C., Perrot, A., Sauvage, D., Barthelemy, C., Muh, J. P., & Lelord, G. (1994). Lack of association between three genetic markers of brain growth factors and infantile autism. Biological Psychiatry, 35, 281-283.
45. Herault, J., Petit, E., Martineau, J., Perrot, A., Lenoir, P., Cherpi, C., Barthelemy, C., Sauvage, D., Mallet, J., & Muh, J. P. (1995). Autism and genetics: Clinical approach and association study with two markers of HRAS gene [see comments]. American Journal of Medical Genetics, 60, 276-281.
46. Hotopf, M., & Bolton, P. (1995). A case of autism associated with partial tetrasomy 15. Journal of Autism Developmental Disorders, 25, 41-49.
47. International Molecular Genetic Study of Autism Consortium. (1998). A full genome screen for autism with evidence for linkage to a region on chromosome 7q. Human Molecular Genetics, 7, 571-578.
48. Jayakar, P., Chudley, A. E., Ray, M., Evans, J. A., Perlov, J., & Wand, R. (1986). Fra(2) (q13) and inv(9) (p11q12) in autism: Causal relationship? American Journal of Medical Genetics, 23, 381-392.
49. Kanner, L. (1943). Autistic disturbances of affective contact. The Nervous Child, 2, 217-250.
50. Kerbeshian, J., Burd, L., Randall, T., Martsolf, J., & Jalal, S. (1990). Autism, profound mental retardation and atypical bipolar disorder in a 33-year-old female with a deletion of 15q12. Journal of Mental Deficiency Research, 34, 205-210.
51. Klauck, S. M., Poustka, F., Benner, A., Lesch, K. P., & Poustka, A. (1997). Serotonin transporter (5-HTT) gene variants associated with autism? Human Molecular Genetics, 6, 2233-2238.
52. Kleczkowska, A., Fryns, J. P., Decock, P., & Van den Berghe, H. (1993). Complex chromosomal rearrangement (CCR), moderate mental retardation and discrete dysmorphic syndrome. Genetic Counseling, 4, 321-324.
53. Krug, B. A., Arick, J. R., & Almond, P. J. (1979). Autism screening instrument for educational planning. Portland, OR: ASIEP Educational Co.
54. Leana-Cox, J., Jenkins, L., Palmer, C. G., Plattner, R., Sheppard, L., Flejter, W. L., Zackowski, J., Tsien, F., & Schwartz, S. (1994). Molecular cytogenetic analysis of inv dup(15) chromosomes, using probes specific for the Prader-Willi/Angelman syndrome region: Clinical implications. American Journal of Human Genetics, 54, 748-756.
55. Li, S. Y., Chen, Y. C., Lai, T. J., Hsu, C. Y., & Wang, Y. C. (1993). Molecular and cytogenetic analyses of autism in Taiwan. Human Genetics, 92, 441-445.
56. Lockwood, D., Hecht, F., Dowman, C., Hecht, B. K., Rizkallah, T. H., Goodwin, T. M., & Allanson, J. (1988). Chromosome subband 17p11.2 deletion: A minute deletion syndrome. Journal of Medical Genetics, 25, 732-737.
57. Lopreiato, J. O., & Wulfsberg, E. A. (1992). A complex chromosome rearrangement in a boy with autism. Journal of Developmental and Behavioral Pediatrics, 13, 281-283.
58. Lord, C., Rutter, M., Goode, S., Heemsbergen, J., Jordan, H., Mawhood, L., & Schopler, E. (1989). Autism Diagnostic Observation Schedule: A standardized observation of communicative and social behavior. Journal of Autism and Developmental Disorders, 19, 185-212.
59. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism Diagnostic Interview-Revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659-685.
60. Ludowese, C. J., Thompson, K. J., Sekhon, G. S., & Pauli, R. M. (1991). Absence of predictable phenotypic expression in proximal 15q duplications. Clinical Genetics, 40, 194-201.
61. Mahr, R. N., Moberg, P. J., Overhauser, J., Strathdee, G., Kamholz, J., Loevner, L. A., Campbell, H., Zackai, E. H., Reber, M. E., Mozley, D. P., Brown, L., Turetsky, B. I., & Shapiro, R. M. (1996). Neuropsychiatry of 18q-syndrome. American Journal of Medical Genetics, 67, 172-178.
62. Mariner, R., Jackson, A. W. III, Levitas, A., Hagerman, R. J., Braden, M., McBogg, P. M., Smith, A. C. M., & Berry, R. (1986). Autism, mental retardation, and chromosomal abnormalities. Journal of Autism and Developmental Disorders, 16, 425-440.
63. Michaelis, R. C., Skinner, S. A., Deason, R., Skinner, C., Moore, C. L., & Phelan, M. C. (1997). Interstitial deletion of 20p: New candidate region for Hirschsprung disease and autism? [in-process citation]. American Journal of Medical Genetics, 71, 298-304.
64. Munk-Jorgensen, P., & Mortensen, P. B. (1997). The Danish Psychiatric Central Register [in-process citation]. Danish Medical Bulletin, 44, 82-84.
65. Murayama, K., Greenwood, R. S., Rao, K. W., & Aylsworth, A. S. (1991). Neurological aspects of del(1q) syndrome. American Journal of Medical Genetics, 40, 488-492.
66. Nielsen, J. (1980). The Danish Cytogenetic Central Register, organization and results. In P. Becker, W. Lenz, F. Vogel, & G. Wendt (Eds.), Topics in human genetics. New York: Georg Thieme Verlag.
67. Pellegrino, J. E., Schnur, R. E., Kline, R., Zackai, E. H., & Spinner, N. B. (1995). Mosaic loss of 15q11q13 in a patient with hypomelanosis of Ito: Is there a role for the P gene? Human Genetics, 96, 485-489.
68. Petit, E., Hérault, J., Martineau, J., Perrot, A., Barthélémy, C., Hameury, L., Sauvage, D., Lelord, G., & Müh, J. P. (1995). Association study with two markers of a human homeogene in infantile autism. Journal of Medical Genetics, 32, 269-274.
69. Pickles, A., Bolton, P., Macdonald, H., Bailey, A., Le Couteur, A., Sim, C.-H., & Rutter, M. (1995). Latent-class analysis of recurrence risks for complex phenotypes with selection and measurement error: A twin and family history study of autism. American Journal of Human Genetics, 57, 717-726.
70. Plattner, R., Heerema, N. A., Howard-Peebles, P. N., Miles, J. H., Soukup, S., & Palmer, C. G. (1993). Clinical findings in patients with marker chromosomes identified by fluorescence in situ hybridization. Human Genetics, 91, 589-598.
71. Reiss, A. L., Feinstein, C., & Rosenbaum, K. N. (1986). Autism and genetic disorders. Schizophrenia Bulletin, 12, 724-738.
72. Ritvo, E. R., Freeman, B. J., Mason-Brothers, A., Mo, A., & Ritvo, A. M. (1985). Concordance for the syndrome of autism in 40 pairs of afflicted twins. American Journal of Psychiatry, 142, 74-77.
73. Ritvo, E. R., Mason-Brothers, A., Menkes, J. H., & Sparkes, R. S. (1988). Association of autism, retinoblastoma, and reduced esterase D activity [letter]. Archives of General Psychiatry, 45, 600.
74. Saliba, J. R., & Griffiths, M. (1990). Brief report: Autism of the Asperger type associated with an autosomal fragile site. Journal of Autism and Developmental Disorders, 20, 569-575.
75. Schinzel, A. (1981). Particular behavioral symptomatology in patients with rarer autosomal chromosome aberrations. In W. Schmid & J. Nielsen (Eds.), Human behaviour and genetics (pp. 195-210). Amsterdam: Elsevier/North-Holland Biomedical Press.
76. Schinzel, A. (1984). Catalogue of unbalanced chromosome aberrations in Man. Berlin: De Gruyter.
77. Schinzel, A. A., Brecevic, L., Bernasconi, F., Binkert, F., Berthet, F., Wuilloud, A., & Robinson, W. P. (1994). Intrachromosomal triplication of 15q11-q13. Journal of Medical Genetics, 31, 798-803.
78. Schopler, E., Reichler, R. J., DeVellis, R. F., & Daly, K. (1980). Toward objective classification of childhood autism: Childhood autism rating scale (CARS). Journal of Autism and Developmental Disorders, 10, 91-103.
79. Schroer, R. J., Phelan, M. C., Michaelis, R. C., Crawford, E. C., Skinner, S. A., Cuccaro, M., Simensen, R. J., Bishop, J., Skinner, C., Fender, D., & Stevenson, R. E. (1998). Autism and maternally derived aberrations of chromosome 15q. American Journal of Medical Genetics, 76, 327-336.
80. Seshadri, K., Wallerstein, R., & Burack, G. (1992). 18q-chromosomal abnormality in a phenotypically normal 21/2-year-old male with autism. Developmental Medicine and Child Neurology, 34, 1005-1009.
81. Shaffer, L. G., McCaskill, C., Hersh, J. H., Greenberg, F., & Lupski, J. R. (1996). A clinical and molecular study of mosaicism for trisomy 17. Human Genetics, 97, 69-72.
82. Slavotinek, A. M., Huson, S. M., & Fitchett, M. (1997). Interstitial deletion of band 3q25. Journal of Medical Genetics, 34, 430-432.
83. Smalley, S. L., Asarnow, R. F., & Spence, M. A. (1988). Autism and genetics. A decade of research. Archives of General Psychiatry, 45, 953-961.
84. Smith, A. C., McGavran, L., Robinson, J., Waldstein, G., Macfarlane, J., Zonona, J., Reiss, J., Lahr, M., Allen, L., & Magenis, E. (1986). Interstitial deletion of (17) (p11.2p11.2) in nine patients. American Journal of Medical Genetics, 24, 393-414.
85. Spence, M. A., Ritvo, E. R., Marazita, M. L., Funderburk, S. J., Sparkes, R. S., & Freeman, B. J. (1985). Gene mapping studies with the syndrome of autism. Behavior Genetics, 15, 1-13.
86. Steffenburg, S., Gillberg, C., Hellgren, L., Andersson, L., Gillberg, I. C., Jakobsson, G., & Bohman, M. (1989). A twin study of autism in Denmark, Finland, Iceland, Norway and Sweden. Journal of Child Psychology and Psychiatry, 30, 405-416.
87. Sundhedsstyrelsen. (1986). Klassifikation af sygdomme. Køabenhavn, Denmark: Schultz Grafisk.
88. Tranebjaerg, L., & Kure, P. (1991). Prevalence of fra(X) and other specific diagnoses in autistic individuals in a Danish county. American Journal of Medical Genetics, 38, 212-214.
89. Vostanis, P., Harrington, R., Prendergast, M., & Farndon, P. (1994). Case reports of autism with interstitial deletion of chromosome 17 (p11.2 p11.2) and monosomy of chromosome 5 (5pter→5p15.3). Psychiatric Genetics, 4, 109-111.
90. Wakabayashi, S. (1979). A case of infantile autism associated with Down's syndrome. Journal of Autism and Developmental Disorders, 9, 31-36.
91. Wandstrat, A. E., Leana-Cox, J., Jenkins, L., & Schwartz, S. (1998). Molecular cytogenetic evidence for a common breakpoint in the largest inverted duplications of chromosome 15. American Journal of Human Genetics, 62, 925-936.
92. Warren, R. P., Odell, J. D., Warren, W. L., Burger, R. A., Maciulis, A., Daniels, W. W., & Torres, A. R. (1996). Strong association of the third hypervariable region of HLA-DR beta 1 with autism. Journal of Neuroimmunology, 67, 97-102.
93. Warren, R. P., Singh, V. K., Cole, P., Odell, J. D., Pingree, C. B., Warren, W. L., DeWitt, C. W., & McCullough, M. (1992). Possible association of the extended MHC haplotype B44-SC30-DR4 with autism. Immunogenetics, 36, 203-207.
94. Warren, R. P., Singh, V. K., Cole, P., Odell, J. D., Pingree, C. B., Warren, W. L., & White, E. (1991). Increased frequency of the null allele at the complement C4b locus in autism. Clinical and Experimental Immunology, 83, 438-440.
95. Weidmer-Mikhail, E., Sheldon, S., & Ghaziuddin, M. (1998). Chromosomes in autism and related pervasive developmental disorders: A cytogenetic study. Journal of Intellectual and Disability Research, 42, 8-12.
96. Wilson, G. N., & Al Saadi, A. A. (1989). Obesity and abnormal behaviour associated with interstitial deletion of chromosome 18 (q12.2q21.1). Journal of Medical Genetics, 26, 62-63.
97. Wing, L. (1981). Language, social, and cognitive impairments in autism and severe mental retardation. Journal of Autism and Developmental Disorders, 11, 31-44.
98. World Health Organisation. (1993). The ICD-10 classification of mental and behavioural disorders. Diagnostic criteria for research. Geneva: Author.