The loss of desmosomes after retinoic acid treatment results in an apparent inhibition of HaCaT keratinocyte differentiation

Archives of Dermatological Research

Volumn 291, Issue 6, 1999, Pages 346-353

  Wanner, Reinhard ^a   Wolff, Bianca ^a   Glowacki, Fabian ^a   Kolde, Gerhard ^b   Wittig, Burghardt ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

AP 2; Cadherin; Desmosome; Differentiation; Retinoic acid

Indexed keywords

CADHERIN; DESMOCOLLIN; DESMOGLEIN; RETINOIC ACID;

ARTICLE; CELL ADHESION; CELL CULTURE; CELL DEATH; CELL DIFFERENTIATION; CELL IMMORTALIZATION; CONTROLLED STUDY; DESMOSOME; ELECTRON MICROSCOPY; EPITHELIUM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; SKIN; TRANSCRIPTION REGULATION;

CADHERINS; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CULTURE MEDIA; DESMOSOMES; HUMANS; KERATINOCYTES; RNA, MESSENGER; TRETINOIN;

EID: 0033012823     PISSN: 03403696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004030050420     Document Type: Article

References (57)

1. Gorbsky G, Steinberg MS (1981) Isolation of the intercellular glycoproteins of desmosomes. J Cell Biol 90: 243-248
2. Cowin P, Mattey D, Garrod D (1984) Identification of desmosomal surface components (desmocollins) and inhibition of desmosome formation by specific Fab′. J Cell Sci 70: 41-60
3. Schwarz MA, Owaribe K, Kartenbeck J, Franke WW (1990) Desmosomes and hemidesmosomes: constitutive molecular components. Annu Rev Cell Biol 6: 461-491
4. Goodwin L, Hill JE, Raynor K, Raszi L, Manabe M, Cowin P (1990) Desmoglein shows extensive homology to the cadherin family of cell adhesion molecules. Biochem Biophys Res Commun 173: 1224-1230
5. Mechanic S, Raynor K, Hill JE, Cowin P (1991) Desmocollins form a distinct subset of the cadherin family of cell adhesion molecules. Proc Natl Acad Sci USA 88: 4476-4480
6. Collins JE, Legan PK, Kenny TP, MacGarvie J, Holton JL, Garrod DR (1991) Cloning and sequence analysis of desmosomal glycoproteins 2 and 3 (desmocollins): cadherin like desmosomal adhesion molecules with heterogeneous cytoplasmic domains. J Cell Biol 113: 381-391
7. Pasdar M, Nelson WJ (1989) Regulation of desmosome assembly in epithelial cells: kinetics of synthesis, transport, and stabilization of desmoglein I, a major protein of the membrane core domain. J Cell Biol 109: 163-177
8. Nilles LA, Parry D, Powers EE, Angst BD, Wagner RM, Green KJ (1991) Structural analysis and expression of human desmoglein: a cadherin-like component of the desmosome. J Cell Sci 99: 809-821
9. Parker AE, Wheeler GN, Arnemann J, Pidsley SC, Ataliotis P, Thomas CL, Rees DA, Magee AI, Buxton RS (1991) Desmosomal glycoproteins II and III. Cadherin-like junctional molecules generated by alternative splicing. J Biol Chem 266: 10438-10445
10. Wheeler GN, Parker AE, Thomas CL, Ataliotis P, Poynter D, Arnemann J, Rutman AJ, Pidsley SC, Watt FM, Rees DA, Buxton RS, Magee AI (1991) Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proc Natl Acad Sci USA 88: 4796-4800
11. Koch PJ, Goldschmidt MD, Zimbelmann R, Troyanovsky R, Franke WW (1992) Complexity and expression patterns of the desmosomal cadherins. Proc Natl Acad Sci USA 89: 353-357
12. 2+-dependent heterophilic interaction between desmosomal cadherins, desmoglein and desmocollin, contributes to cell-cell adhesion. J Cell Biol 138: 193-201
13. Amagai M. (1995) Adhesion molecules. I: keratinocyte-keratinocyte interactions; cadherins and pemphigus. J Invest Dermatol 104: 146-152
14. Kouklis PD, Hutton E, Fuchs E (1994) Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins. J Cell Biol 127: 1049-1060
15. Hennings H, Michael D, Cheng C, Steinert P, Holbrook K, Yuspa SH (1980) Calcium regulation of growth and differentiation of mouse epidermal cells in culture. Cell 19: 245-254
16. Watt F, Mattey DL, Garrod DR (1984) Calcium-induced reorganization of desmosomal components in cultured human keratinocytes. J Cell Biol 99: 2211-2215
17. Jones JCR, Goldman RD (1985) Intermediate filaments and the initiation of desmosome assembly. J Cell Biol 101: 506-517
18. Duden R, Franke WW (1988) Organization of desmosomal plaque proteins in cells growing at low calcium concentration. J Cell Biol 107: 1049-1063
19. 2+ ion medium. J Cell Biol 113: 881-892
20. Penn EJ, Hobson C, Rees DA, Magee AI (1987) Structure and assembly of desmosome junctions: biosynthesis, processing, and transport of the major protein and glycoprotein in cultured epithelial cells. J Cell Biol 105: 57-68
21. Penn EJ, Burdett IDJ, Hobson C. Magee AI, Rees DA (1987) Structure and assembly of desmosome junctions: biosynthesis and turnover of the major desmosome components of Madin-Darby canine kidney cells in low-calcium medium. J Cell Biol 105: 2327-2334
22. Gumbiner B, Stevenson B, Grimaldi A (1988) The role of cell adhesion molecule uvomorulin in the formation and maintenance of the epithelial junctional complex. J Cell Biol 107: 1575-1587
23. Kartenbeck J, Schmid E, Franke WW, Geiger B (1982) Different modes of internalization of proteins associated with adherens junctions and desmosomes: experimental separation of lateral contacts induces endocytosis of desmosomal plaque material. EMBO J 2: 735-742
24. Mattey DL, Garrod DR (1986) Splitting and internalization of the desmosomes of cultured kidney epithelial cells by reduction in calcium concentration. J Cell Sci 85: 113-124
25. Holm PK, Hansen SH, Sandvig K, Deurs B van (1993) Endocytosis of desmosomal plaques depends on intact actin filaments and leads to a nondegradative compartment. Eur J Cell Biol 62: 362-371
26. Demlehner MP, Schäfer S, Grund C, Franke WW (1995) Continual assembly of half-desmosomal structures in the absence of cell contacts and their frustrated endocytosis: a coordinated sisiphus cycle. J Cell Biol 131: 745-760
27. Schäfer S, Koch PJ, Franke WW (1994) Identification of the ubiquitous human desmoglein, Dsg2, and the expression catalogue of the desmoglein subfamily of desmosomal cadherins. Exp Cell Res 211: 391-399
28. Nuber UA, Schäfer S, Schmidt A, Koch PJ, Franke WW (1995) The widespread human desmocollin DSC2 and tissue-specific patterns of synthesis of various desmocollin subtypes. Eur J Cell Biol 66: 69-74
29. Arnemann J, Sullivan KH, Magee AI, King IA, Buxton RS (1993) Stratification related expression of isoforms of the desmosomal cadherins in human epidermis. J Cell Sci 104: 741-750
30. Amagai M, Koch PJ, Nishikawa T, Stanley JR (1996) Pemphigus vulgaris antigen (desmoglein 3) is localized in the lower epidermis, the site of blister formation in patients. J Invest Dermatol 106: 351-355
31. Theis DG, Koch PJ, Franke WW (1993) Differential synthesis of type 1 and type 2 desmocollin mRNAs in human stratified epithelia. Int J Dev Biol 37: 101-110
32. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE (1988) Normal keratinization in a spontaneously immortalized human keratinocyte cell line. J Cell Biol 106: 761-771
33. 2+. Differentiation 54: 201-217
34. Chambon P (1996) A decade of molecular biology of retinoic acid receptors. FASEB J 10: 9540-9541
35. Fisher GJ, Voorhees JJ (1996) Molecular mechanisms of retinoid actions in skin. FASEB J 10: 1002-1013
36. Rosenthal DS, Griffith, CEM, Yuspa SH, Roop DR, Voorhees JJ (1992) Acute or chronic topical retinoic acid treatment of human skin in vivo alters the expression of epidermal transglutaminase, loricrin, involucrin, filaggrin, and keratins 6 and 13 but not keratins 1, 10, and 14. J Invest Dermatol 98: 343-350
37. Wanner R, Panteleyev A, Henz BM, Rosenbach T (1996) Retinoic acid affects the expression rate of the differentiation-related genes aryl hydrocarbon receptor, ARNT and keratin 4 in proliferative keratinocytes only. Biochim Biophys Acta 1317: 105-111
38. Wanner R, Brömmer S, Czarnetzki BM, Rosenbach T (1995) The differentiation-related upregulation of aryl hydrocarbon receptor transcript levels is suppressed by retinoic acid. Biochem Biophys Res Commun 209: 706-711
39. Kolde G, Knop J (1986) Ultrastructural morphometry of epidermal Langerhans cells: introduction of a simple method for a comprehensive quantitative analysis of the cells. Arch Dermatol Res 278: 298-301
40. Iwatsuki K, Harada H, Yokote R, Kaneko F (1995) Differences in the expression of pemphigus vulgaris antigens during epidermal differentiation. Br J Dermatol 133: 209-216
41. Merker H, Stüttgen G (1975) Electron microscope findings after toxic doses of vitamin A acid in man. Acta Derm Venereol 74: 64-72
42. Williams ML, Elias PM (1981) Nature of skin fragility in patients receiving retinoids for systemic effect. Arch Dermatol Res 117: 611-619
43. Allen E, Yu Q-C, Fuchs E (1996) Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation and epidermal differentiation. J Cell Biol 133: 1367-1382
44. Amagai M, Karpati S, Prussick R, Klaus KV, Stanley JR (1992) Autoantibodies against the amino-terminal cadherin-like binding domain of pemphigus vulgaris antigen are pathogenic. J Clin Invest 90: 919-926
45. Orfanos CE, Ehlert R, Gollnick H (1987) The retinoids. A review of their clinical pharmacology and therapeutic use. Drugs 34: 459-503
46. Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR (1997) Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 137: 1091-1102
47. Pilkington T, Brogden RN (1992) Acitretin. A review of its pharmacology and therapeutic use. Drugs 43: 597-627
48. Humphries JD, Parry EJ, Watson REB, Garrod DR, Griffiths CEM (1998) All-trans retinoic acid compromises desmosome expression in human epidermis. Br J Dermatol 139: 577-584
49. Milstone LM, McGuire J, LaVigne JF (1982) Retinoic acid causes premature desquamation of cells from confluent cultures of stratified squamous epithelia. J Invest Dermatol 79: 253-260
50. Mitchell PJ, Timmons PM, Hebert JM, Rigby PWJ, Tjian R (1991) Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis. Genes Dev 5: 105-119
51. Leask A, Byrne C, Fuchs E (1991) Transcription factor AP2 and its role in epidermal-specific gene expression. Proc Natl Acad Sci USA 88: 7948-7952
52. Bauer R, Imhof A, Pscherer A, Kopp H, Moser M, Seegers S, Kerschner M, Tainsky MA, Hofstaedter F, Buettner R (1994) The genomic structure of the human AP-2 transcription factor. Nucleic Acids Res 22: 1413-1420
53. Wanner R, Zhang J, Dorbic T, Mischke D, Henz BM, Wittig B, Rosenbach T (1997) The promoter of the HaCaT keratinocyte differentiation-related gene keratin 4 contains a functional AP-2 binding site. Arch Dermatol Res 289: 705-708
54. Wanner R, Zhang J, Henz BM, Rosenbach T (1996) AP-2 gene expression and modulation by retinoic acid during keratinocyte differentiation. Biochem Biophys Res Commun 223: 666-669
55. Behrens J, Lowrick O, Klein-Hitpass L, Birchmeier W (1991) The E-cadherin promoter: functional analysis of a GC-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci U S A 88: 11495-11499
56. Silos SA, Tamai K, Li K, Kivirikko S, Kouba D, Christiano AM, Uitto J (1996) Cloning of the gene for human pemphigus vulgaris antigen (desmoglein 3), a desmosomal cadherin. Characterization of the promoter region and identification of a keratinocyte-specific cis-element. J Biol Chem 271: 17504-17511
57. Denning MF, Guy SG, Ellerbroek SM, Norvell SM, Kowalczyk AP, Green KJ (1998) The expression of desmoglein isoforms in cultured human keratinocytes is regulated by calcium, serum, and protein kinase C. Exp Cell Res 239: 50-59