Efficient human IFN-γ expression in the mammary gland of transgenic mice

Journal of Interferon and Cytokine Research

Volumn 19, Issue 2, 1999, Pages 137-144

  Lagutin, Oleg V ^a   Dobrovolsky, Vasily N ^a,b   Vinogradova, Tatyana V ^a   Kyndiakov, Boris N ^a   Khodarovich, Yuri M ^a   Jenkins, Nigel ^c   James, David ^d   Markham, Nikola ^d   Larionov, Oleg A ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^c DE MONTFORT UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF KENT   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT GAMMA INTERFERON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; HERITABILITY; HYBRID GENE; LACTATION; MAMMARY GLAND; MILK LEVEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYBRIDIZATION, GENETIC; INTERFERON TYPE II; LACTOGLOBULINS; MAMMARY GLANDS, ANIMAL; MICE; MICE, TRANSGENIC; MILK; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

ANIMALIA; MUS MUSCULUS; OVIS ARIES;

EID: 0033012795     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/107999099314289     Document Type: Article

References (42)

1. SMITH, D.M., MAYHEW, E., RESZKA, R., ITO, M., and O'MALLEY, J.A. (1990). Antiviral and antiproliferative properties of liposome-associated human interferon-gamma. J. Interferon Res. 10, 153-160.
2. RINDERKNECHT, E., O'CONNOR, B.H., and RODRIGUEZ, H. (1984). Natural human interferon-gamma. Complete amino acid sequence and determination of sites of glycosylation. J. Biol. Chem. 259, 6790-6797.
3. JAY, E., and ROMMENS, J. (1984). High-level expression of chemically synthesized gene for human interferon-γ using a prokaryotic expression vector. Proc. Natl. Acad. Sci. USA 81, 2290-2294.
4. DERYNCK, R., SINGH, A., and GOEDDEL, D.V. (1983). Expression of the human interferon-γ cDNA in yeast. Nucleic Acids Res. 11, 1819-1837.
5. OGONAH, O.W., FREEDMAN, R.B., JENKINS, N., PATEL, K., and ROONY, B.C. (1996). Isolation and characterization of an insect-cell line able to perform complex N-Iinked glycosylation on recombinant proteins. Bio/Technology 14, 197-202.
6. MORY, Y., BEM-BARAK, J., SEGEV, D., COHEN, B., NOVICK, D., FISHER, D.G, RUBINSTEIN, M., KARGMAN, S., LILBERSTEIN, A., VIGNERON, M., and REVEL, M. (1986). Efficient constitutive production of human IFN-γ in Chinese hamster ovary cells. DNA 5, 181-193.
7. HENNINGHAUSEN, L. (1990). The mammary gland as a bioreactor: production of foreign proteins in milk. Protein Expression Purif. 1, 3-8.
8. WILMUT, I., ARCHIBALD, A.L., HARRIS, S., McCLENAGHAN, M., SIMONS, J.P., WHITELAW, C.B., and CLARK, A.J. (1990). Modification of milk composition. J. Reprod. Fertil. 41(Suppl.) 135-146.
9. MAGA, E.A., and MURRAY, J.D. (1995). Mammary gland expression of transgenes and the potential for altering the properties of milk. Bio/Technology 13, 1452-1457.
10. MEADE, H., GATES, L., LACY, E., and LONBERG, N. (1990). Bovine alpha S1-casein gene sequences direct high level expression of active human urokinase in mouse milk. Bio/Technology 8, 443-446.
11. ARCHIBALD, A.L., McCLENAGHAN, M., HORNSEY, V., SIMONS, J.P., and CLARK, A.J. (1990). High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice. Proc. Natl. Acad. Sci. USA 87, 5178-5182.
12. WRIGHT, G., CARVER, A., COTTOM, D., REEVES, D., SCOTT, A., SIMONS, P., WILMUT, I., GARNER, I., and COLMAN, A. (1991). High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Bio/Technology 9, 830-834.
13. EBERT, K.M., SELGRATH, J.P., DITULLIO, P., DENMAN, J., SMITH, T.E., MEMON, M.A., SCHINDLER, J.E., MONASTERSKY, G.M., VITALE, J.A., and GORDON, K. (1991). Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Bio/Technology 9, 835-838.
14. REDDY, V.B., VITALE, J.A., WEI, C., MONSTOYA-ZAVALA, M., STICE, S.L., BALISE, J., and ROBL, J.M. (1991). Expression of human growth hormone in the milk of transgenic mice. Anim. Biotechnol. 2, 15-29.
15. BARASH, I., FAERMAN, A., BARUCH, A., NATHAN, M., HURWITZ, D.R., and SHANI, M. (1993). Synthesis and secretion of human serum albumin by mammary gland explants of virgin and lactating transgenic mice. Transgenic Res. 2, 266-276.
16. WEI, Y., YARUS, S., GREENBERG, N.M., WHITSETT, J., and ROSEN, J.M. (1995). Production of human surfactant protein C in milk of transgenic mice. Transgenic Res. 4, 232-240.
17. ERNST, L.K., GOLDMAN, I.L., ZINOV'EVA, N.A., BAKSHEEV, E.D., GOGOLEVSKII, P.A., KADULIN, S.G., and BREM, G. (1995). Development of sheep, transgenic in genetic design of alphaS1-casein/chymosin. Dokl. Acad. Nauk. 345, 555-558.
18. PRUNKARD, D., COTTINGHAM, I., GARNER, I., BRUCE, S., DALRYMPLE, M., LASSER, G., BISHOP, P., and FOSTER, D. (1996). High-level expression of recombinant human fibrinogen in the milk of transgenic mice. Nature Biotechnol. 14, 867-871.
19. BIJVOET, A.G.A., KROOS, M.A., PIEPER, F.R., DE BOER, H.A., REUSER, A.J.J., VAN DER PLOEG, A.T., and VERBEET, M.P. (1996). Expression of cDNA-encoded human acid alpha-glucosidase in milk of transgenic mice. Biochim. Biophys. Acta 1308, 93-96.
20. s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice. Transgenic Res. 6, 75-84.
21. DOBROVOLSKY, V.N., LAGUTIN, O.V., VINOGRADOVA, T.V., FROLOVA, I.S., KUZNETSOV, V.P., and LARIONOV, O.A. (1993). Human gamma-interferon expression in the mammary gland of transgenic mice. FEBS Lett. 319, 181-184.
22. GRAY, P.W., and GOEDDEL, D.V. (1982). Structure of the human immune interferon gene. Nature 298, 859-863.
23. HOGAN, B., CONSTANTINI, F., and LACY, E. (1986). Manipulating the Mouse Embryo. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
24. INNEIS, M.A., GELFAND, D.H., SNINSKY, J.J., and WHITE, T.J. ((1990). PCR Protocols. A Guide to Methods and Applications. New York: Academic Press.
25. CHOMCZYNSKI, P. (1992). One-hour downward alkaline capillary transfer for blotting of DNA and RNA. Anal. Biochem. 201, 134-139.
26. CHIRGWIN, J.M., PRZYBYLA, A.E., MacDONALD, R.J., and RUTTER, W.J. (1979). Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 18, 5294-5299.
27. WEBSTER, J., WALLACE, R.M., CLARK, A.J., and WHITELAW, C.B.A. (1995). Tissue-specific, temporally regulated expression mediated by the proximal ovine beta-lactoglobulin promoter in transgenic mice. Cell. Mol. Biol. Res. 41, 11-15.
28. WHITELAW, C.B.A., HARRIS, S., McCLENAGHAN, M., SIMONS, J.P., and CLARK, A.J. (1992). Position-independent expression of the ovine beta-lactoglobulin gene in transgenic mice. Biochem. J. 286, 31-39.
29. HARRIS, S., McCLENAGHAN, M., SIMONS, J.P., ALI, S., and CLARK, A.J. (1991). Developmental regulation of the sheep beta-lactoglobulin gene in the mammary gland of transgenic mice. Dev. Genet. 12, 299-307.
30. PALMITER, R.D., SANDGREN, E.P., AVARBOCK, M.R., ALLEN, D.D., and BRINSTER, R.L. (1991). Heterologous introns can enhance expression of transgenes in mice. Proc. Natl. Acad. Sci. USA 88, 478-482.
31. BRUCE, C., WHITELAW, A., ARCHIBALD, A.L., HARRIS, S., McCLENAGHAN, M., SIMONS, J.P., and CLARK, A.J. (1991). Targeting expression to the mammary gland: intronic sequences can enhance the efficiency of gene expression in transgenic mice. Transgenic Res. 1, 3-13.
32. BARASH, I., FAERMAN, A., RATOVITSKY, T., PUZIS, R., NATHAN, M., HURWITZ, D.R., and SHANI, M. (1994). Ectopic expression of beta-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation and in situ localization. Transgenic Res. 3, 141-151.
33. FARINI, E., and WHITELAW, C.B.A. (1995). Ectopic expression of beta-lactoglobulin transgenes. Mol. Gen. Genet. 246, 734-738.
34. LEE, C.S., KIM, K., YU, D.Y., and LEE, K.K. (1996). An efficient expression of human growth hormone (hGH) in the milk of transgenic mice using rat beta-casein/hGH fusion genes. Appl. Biochem. Biotechnol. 56, 211-222.
35. PALEYANDA, R.K., ZHANG, D.W., HENNINGHAUSEN, L., McKNIGHT, R.A., and LUBON, H. (1994). Regulation of human protein C gene expression by the mouse WAP promoter. Transgenic Res. 3, 335-343.
36. PESTKA, S., LANGER, J.A., ZOON, K.C., and SAMUEL, C.E. (1987). Interferons and their actions. Annu. Rev. Biochem. 56, 727-777.
37. LETOURNEUR, O., SECHI, S., WILLETTEBROWN, J., ROBERTSON, M.W., and KINET, J.P. (1995). Glycosylation of human truncated Fc-epsilon-R1 alpha-chain is necessary for efficient folding in the endoplasmic reticulum. J. Biol. Chem. 270, 8249-8266.
38. HERSCOVICS, A.O., and ORLEAN, P. (1993). Glycoprotein biosynthesis in yeast. FASEB J. 7, 540-550.
39. JENKINS, N., PAREKH, R.B., and JAMES, D.C. (1996). Getting the glycosylation right: implications for the biotechnology industry. Nature Biotech. 14, 975-981.
40. JENKIS, N., and CURLING, E.M. (1995). Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb. Technol. 16, 353-364.
41. LEE, E.U., ROTH, J., and PAULSON, J.C. (1989). Alteration of terminal glycosylation sequences on N-linked oligosaccharides of Chinese hamster ovary cells by expression of beta-galactoside alpha 2,6-sialytransferase. J. Biol. Chem. 264, 13848-13855.
42. JAMES, D.C., FREEDMAN, R.B., HOARE, M., OGONAH, O.W., ROONEY, B.C., LARIONOV, O.A., DOBROVOLSKY, V.N., LAGUTIN, O.V., and JENKINS, N. (1995). N-Glycosylalion of recombinant human Interferon-γ produced in different animal expression systems. Bio/Technology 13, 592-596.