Influence of enzyme distribution and diffusion on permeation profile of prodrug through viable skin: Theoretical aspects for several steady-state fluxes in two transport directions

Biological and Pharmaceutical Bulletin

Volumn 22, Issue 6, 1999, Pages 623-626

  Hatanaka, Tomomi ^a   Rittirod, Theera ^a   Katayama, Kazunori ^a   Koizumi, Tamotsu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Diffusion; Enzyme distribution; Metabolite; Physical model; Prodrug; Skin metabolism; Skin transport; Transport direction

Indexed keywords

PRODRUG;

ARTICLE; DIFFUSION; ENZYME LOCALIZATION; METABOLIC RATE; PARTITION COEFFICIENT; PHYSICAL MODEL; SIMULATION; SKIN; SKIN PERMEABILITY; THEORY; TRANSPORT KINETICS;

EID: 0033012431     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.22.623     Document Type: Article

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