Tumor necrosis factor a microsatellite polymorphism is associated with rheumatoid arthritis severity through an interaction with the HLA-DRB1 shared epitope

Arthritis and Rheumatism

Volumn 42, Issue 3, 1999, Pages 438-442

  Mu, Hua ^a   Chen, John J ^b   Jiang, Yebin ^c   King, Mary Claire ^a   Thomson, Glenys ^b   Criswell, Lindsey A ^c,d  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Division of Rheumatology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; AMINO ACID SEQUENCE; ARTICLE; CENTROMERE; DISEASE SEVERITY; EPITOPE MAPPING; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCATION; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ADULT; ALLELES; ARTHRITIS, RHEUMATOID; DNA, SATELLITE; EPITOPES; FEMALE; HISTOCOMPATIBILITY TESTING; HLA-DR ANTIGENS; HUMANS; LONGITUDINAL STUDIES; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033011051     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(199904)42:3<438::AID-ANR7>3.0.CO;2-F     Document Type: Article

References (32)

1. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30: 1205-13.
2. Rigby AS, Silman AJ, Gregory JC, Ollier WER, Voelm L, Khan MA, et al. Investigating the HLA component in rheumatoid arthritis: an (additive) dominant mode of inheritance is rejected, a recessive mode is preferred. Genet Epidemiol 1991;8:153-75.
3. Wordsworth P, Pile KD, Buckley JD, Lanchbury JSS, Ollier B, Lathrop M, et al. HLA heterozygosity contributes to susceptibility to rheumatoid arthritis. Am J Hum Genet 1992;51:585-91.
4. Hasstedt SJ, Clegg DO, Ingles L, Ward RH. HLA-linked rheumatoid arthritis. Am J Hum Genet 1994;55:738-46.
5. Lynn AH, Kwoh CK, Venglish CM, Aston CE, Chakravarti A. Genetic epidemiology of rheumatoid arthritis. Am J Hum Genet 1995;57:150-9.
6. Criswell LA, Mu H, Such CL, King M-C. Inheritance of the shared epitope and long-term outcomes of rheumatoid arthritis among community-based females. Genet Epidemiol 1998;15:61-72.
7. Brennan FM, Maini RN, Feldmann M. TNF-α: a pivotal role in rheumatoid arthritis. Br J Rheumatol 1992;21:293-8.
8. Griffiths RJ, Pettipher ER, Koch K, Farrell CA, Breslow R, Conklyn MJ, et al. Leukotriene B4 plays a critical role in the progression of collagen-induced arthritis. Proc Natl Acad Sci U S A 1995;92:517-21.
9. Keffer J, Probert L, Cazlaris H, Georgopoulos S, Kaslaris E, Kioussis D, et al. Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis. EMBO J 1991;10:4025-31.
10. Moreland LW, Baumgartner SW, Schiff MH, Tindall EA, Fleischmann RM, Weaver AL, et al. Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 1997;337:141-7.
11. Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Bijl H, et al. Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis. Lancet 1994;344:1125-7.
12. Westendorp RGJ, Langermans JAM, Huizinga TWJ, Elouali AH, Verweij CL, Boomsma DI, et al. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 1997;349: 170-3.
13. Udalova IA, Nedospasov SA, Webb GC, Chaplin DD, Turestskaya RL. Highly informative typing of the human TNF locus using six adjacent polymorphic markers. Genomics 1993;16:180-6.
14. Pociot F, Briant L, Jongeneel CV, Molvig J, Worsaae H, Abbal M, et al. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-α and TNF-β by human mononuclear cells: a possible link to insulin-dependent diabetes mellitus. Eur J Immunol 1993;23: 224-31.
15. Hajeer AH, Worthington J, Silman AJ, Ollier WER. Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRB1*04-bearing haplotypes in rheumatoid arthritis patients. Arthritis Rheum 1996;39:1109-14.
16. Mulcahy B, Waldron-Lynch F, McDermott MF, Adams C, Amos CI, Zhu DK, et al. Genetic variability in the tumor necrosis factor-lymphotoxin region influences susceptibility to rheumatoid arthritis. Am J Hum Genet 1996;59:676-83.
17. Moxlcy G, Meyer J, Singh R, Han J. Microsatellite haplotypes of tumor necrosis factor (TNFab) show linkage disequilibrium with shared-epitope DRB1 alleles: Arthritis Research Conference. Bethesda (MD): National Institutes of Health; 1997.
18. Yelin EH, Henke CJ, Kramer JS, Nevitt MC, Shearn M, Epstein WV. A comparison of the treatment of rheumatoid arthritis in health maintenance organizations and fee-for-service practices. N Engl J Med 1985;312:962-7.
19. Deighton CM, Wentzel J, Cavanagh G, Roberts DF, Walker DJ. Contribution of inherited factors to rheumatoid arthritis. Ann Rheum Dis 1992;51:182-5.
20. Weyand CM, Hicok KC, Conn DL, Goronzy JJ. The influence of HLA-DRB1 genes on disease severity in rheumatoid arthritis. Ann Intern Med 1992;117:801-6.
21. Meyer JM, Han J, Singh R, Moxley G. Sex influences on the penetrance of HLA shared-epitope genotypes for rheumatoid arthritis. Am J Hum Genet 1996;58:371-83.
22. Genant HK, Jiang Y, Peterfy C, Lu Y, Rédei J, Countryman PJ. Assessment of rheumatoid arthritis using a modified scoring method on digitized and original radiographs. Arthritis Rheum 1998;41:1583-90.
23. Jiang Y, Peterfy C, Lu Y, Reidei J, Countryman P, Genant HK. Semiquantitative scoring of high-resolution laser-digitized images versus original conventional radiographs in patients with rheumatoid arthritis [abstract]. Radiology 1998;206:857.
24. Bidwell JL, Bignon JD. DNA-RFLP methods and interpretation scheme for HLA-DR and DQ typing. Eur J Immunogenet 1991; 18:5-22.
25. Petersdorf EW, Smith AG, Mickelson EM, Martin PJ, Hansen JA. Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain. Immunogenetics 1991;33:267-75.
26. Ota M, Seki T, Fukushima H, Tsuji K, Inoko H. HLA-DRB1 senotyping by modified PCR-RFLP method combined with group-specific primers. Tissue Antigens 1992;39:187-202.
27. SAS Institute, Inc. SAS/STAT user's guide. 6th ed. Cary (NC): SAS Institute, Inc.; 1989.
28. SAS Institute, Inc. SAS/STAT software: changes and enhancements. SAS technical report P-229. 6.07 ed. Cary (NC): SAS Institute, Inc.; 1992.
29. Breslow N, Day NE. The analysis of case-control studies: statistical methods in cancer research. Vol. I. Lyon: IARC; 1980.
30. Frankel WN, Schork NJ. Who's afraid of epistasis? Nat Genet 1996;14:371-3.
31. Teller K, Budhai L, Zhang M, Haramati N, Keiser HD, Davidson A. HLA-DRB1 and DQB typing of Hispanic American patients with rheumatoid arthritis: the "shared epitope" hypothesis may not apply. J Rheumatol 1996;23:1363-8.
32. McDaniel DO, Alarcon GS, Pratt PW, Reveille JD. Most African-American patients with rheumatoid arthritis do not have the rheumatoid antigenic determinant (epitope). Ann Intern Med 1995;123:181-7.