Analysis of three suggested psoriasis susceptibility loci in a large Swedish set of families: Confirmation of linkage to chromosome 6p (HLA region), and to 17q, but not to 4q

Human Heredity

Volumn 49, Issue 1, 1999, Pages 2-8

  Enlund, Fredrik ^a   Samuelsson, Lena ^a   Enerbäck, Charlotta ^a   Inerot, Annica ^a   Wahlström, Jan ^a   Yhr, Maria ^a   Torinsson, Åsa ^a   Martinsson, Tommy ^a   Swanbeck, Gunnar ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

HLA; Linkage analysis; Psoriasis

Indexed keywords

DNA MARKER; HLA ANTIGEN; LYMPHOTOXIN;

ARTICLE; CHROMOSOME 17Q; CHROMOSOME 4Q; CHROMOSOME 6P; FAMILY STUDY; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PSORIASIS; SWEDEN;

CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 4; CHROMOSOMES, HUMAN, PAIR 6; FAMILY HEALTH; GENETIC PREDISPOSITION TO DISEASE; HLA ANTIGENS; HUMANS; LINKAGE (GENETICS); LINKAGE DISEQUILIBRIUM; LOD SCORE; PSORIASIS; SWEDEN;

EID: 0033010024     PISSN: 00015652     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022832     Document Type: Article

References (28)

1. Lomholt G: Psoriasis: Prevalence, spontaneous course and genetics: A Census Study on the Prelevance of Skin Disease on the Faroe Islands. Copenhagen, GEC Gad, 1963.
2. Hellgren L: Psoriasis: The Prevalence of Sex, Age and Occupational Groups in Total Populations in Sweden. Morphology, Inheritance Associations with other Skin and Rheumatic Diseases. Stockholm, Almquist & Wiksell, 1967.
3. Swanbeck G, Inerot A, Martinsson T, Wahlström J, Enerbäck C, Enlund F, Yhr M: Age at onset and different types of psoriasis. Br J Dermatol 1995;133:768-773.
4. Baadsgaard O, Fisher G, Voorhees JJ, Cooper KD: The role of the immune system in the pathogenesis of psoriasis. J Invest Dermatol 1990;95:32S-34S.
5. Valdimarsson H, Baker B, Jonsdottir I, Fry L: Psoriasis: A disease of abnormal keratinocyte proliferation induced by T-lymphocytes. Immunol Today 1986;7:256-259.
6. Wuepper KD, Coulter SN, Haberman A: Psoriasis vulgaris: A genetic approach. Soc Invest Dermatol 1990;5(suppl):2S-3S.
7. Tiilikainen A, Lassus A, Karvonen J, Vartiainen P, Julin M: Psoriasis and HLA-Cw6. Br J Dermatol 1980;102:179-183.
8. Christophers E, Henseler T: Psoriasis type I and type II as subtypes of nonpustular psoriasis; in Roenigh HH, Marbach HI (eds): Psoriasis, ed 2. New York, Marcel Dekker, 1990, pp 15-21.
9. Enerbäck C, Martinsson T, Inerot A, Wahlström J, Enlund F, Yhr M, Swanbeck G: Evidence that HLA-Cw6 determines early onset of psoriasis - obtained using sequence-specific primers (PCR-SSP). Acta Derm Venereol (Stockh) 1997;77:273-276.
10. Brandrup F, Holm N, Grunnet N, Henningsen K, Hansen H: Psoriasis in monozygotic twins: Variations in expression in individuals with identical genetic constitution. Acta Dermatol (Kyoto) 1982;62:229-236.
11. Duffy D, Spelman L, Martin N: Psoriasis in Australian twins. J Am Acad Dermatol 1993;29:428-434.
12. Tomfohrde J. Silverman A, Barnes R, Fernandez-Vina MA, Young M, Lory D, Morris L, Wuepper KD, Stastny P, Menter A, Bowcock A: Gene for familiar psoriasis susceptibility mapped to the distal end of human chromosome 17q. Science 1994;264:1141-1145.
13. Matthews D, Fry L, Powles A, Weissenbach J, Williamson R: Confirmation of genetic heterogeneity in familial psoriasis. J Med Genet 1995;2:546-548.
14. Nair RP, Guo S-W, Jenisch S, Henseler T, Lange EM, Terhune M, Westphal T, Christophers E, Voorhees JJ, Elder JT: Scanning chromosome 17 for psoriasis susceptibility: Lack of evidence for a distal 17q locus. Hum Hered 1995;45:219-230.
15. Abele D, Dobson R, Graham J, Hill C: Heredity and psoriasis: Study of a large family. Arch Dermatol 1963;88:89-99.
16. Swanbeck G, Inerot A, Martinsson T, Wahlström J: A population genetic study of psoriasis. Br J Dermatol 1994;131:32-39.
17. Matthews D, Fry L, Powles A, Weber J, McCarthy M, Fisher E, Davies K, Williamson R: Evidence that a locus for familial psoriasis maps to chromosome 4q. Nat Genet 1996;14:231-233.
18. Trembath RC, Clough RL, Rosbotham JL, Jones AB, Camp RDR, Frodsham A, Browne J, Barber R, Terwilliger J, Lathrop GM, Barker JNWN: Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis. Hum Mol Genet 1997;6:813-820.
19. Nair RP, Henseler T, Jenisch S, Stuart P, Bichakjian CK, Lenk W, Westphal E, Guo S-W, Christophers E, Voorhees JJ, Elder JT: Evidence for two psoriasis susceptibility loci (HLA and 17q) and two novel candidate regions (16q and 20p) by genome-wide scan. Hum Mol Genet 1997;8:1349-1356.
20. Kruglyak L, Daly M, Reeve-Daly M, Lander E: Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 1996;58:1347-1363.
21. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (eds): Current protocols in molecular biology. New York, Wiley Interscience, 1995.
22. Nedospasov SA, Udalova IA, Kuprash DV, Turetskaya RL: DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNFβ) gene. J Immunol 1991;147:1053-1059.
23. Jongeneel CV, Briant L, Udalova I A, Sevin A, Nedospasov SA, Cambon-Thomsen A: Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes. Proc Natl Acad Sci USA 1991;88:9717-9721.
24. Martin M, Mann D, Carrington M: Recombination rates across the HLA complex: Use of microsatellites as a rapid screen for recombinant chromosomes. Hum Mol Genet 1995;4:423-428.
25. Foissac A, Crouau-Roy B, Fauré S, Thomsen M, Cambon-Thomsen A: Microsatellites in the HLA region: An overview. Tissue Antigens 1997;49:197-214.
26. Sham PC, Curtis D: An extended transmission/disequilibrium test (TDT) for multi-allele marker loci. Ann Hum Genet 1995;59:323-326
27. Lander E, Kruglyak L: Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-247.
28. Dib C, Fauré S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach J: A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 1996;380:152-154.