Serum leptin and gonadotropin levels in patients with anorexia nervosa during weight gain

Molecular Psychiatry

Volumn 4, Issue 1, 1999, Pages 71-75

  Ballauff, A ^a   Ziegler, A ^a   Emons, G ^a   Sturm, G ^a   Blum, W F ^b,c   Remschmidt, H ^a   Hebebrand, J ^a,d  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c LILLY DEUTSCHLAND GMBH   (Germany)

^d Clinical Research Group   (Germany)

Author keywords

Amenorrhea; Eating disorder; Fertility; Follicle stimulating hormone; Luteinizing hormone; Reproduction

Indexed keywords

FOLLITROPIN; GONADOTROPIN; LEPTIN; LUTEINIZING HORMONE;

ADOLESCENT; ADULT; AMENORRHEA; ANOREXIA NERVOSA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MENSTRUAL CYCLE; PRIORITY JOURNAL; SCHOOL CHILD; WEIGHT GAIN;

EID: 0033008979     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4000478     Document Type: Article

References (18)

1. 1 Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet 1996; 12: 318-320.
2. 2 Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997; 99: 391-395.
3. 3 Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 18: 250-252.
4. 4 Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA 1997; 94: 1023-1028.
5. 5 Yu WH, Walczewska A, Karanth S, McCann SM. Nitric oxide mediates leptin-induced luteinizing hormone-releasing hormone (LHRH) and LHRH and leptin-induced LH release from the pituitary gland. Endocrinology 1997; 138: 5055-5058.
6. 6 Matkovic V, Ilich JZ, Skugor M, Badenhop NE, Goel P, Clairmont A et al. Leptin is inversely related to age at menarche in human females. J Clin Endocrinol Metab 1997; 82: 3239-3245.
7. 7 Blum WF, Englaro P, Hanitsch S, Juul A, Hertel NT, Muller J et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, developmental stage and testosterone. J Clin Endocrinol Metab 1997; 82: 2904-2910.
8. 8 Garcia-Mayor RV, Andrade MA, Rios M, Lage M, Dieguez C, Casanueva FF. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadol hormones, and pubertal stage. J Clin Endocrinol Metab 1997; 82: 2849-2855.
9. 9 Licinio J, Negrao AB, Mantzoros C, Kaklamani V, Wong ML, Bongiorno PB et al. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women. Proc Natl Acad Sci USA 1998; 95: 2541-2546.
10. 10 Clement K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.
11. 11 Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated witli hypogonadism and morbid obesity. Nature Genet 1998; 18: 213-215.
12. 12 Laughlin GA, Yen SSC. Hypoleptinemia in women athletes: absence of a diurnal rhythm with amenorrhea. J Clin Endocrinol Metab 1997; 82: 318-321.
13. 13 Tataranni PA, Monroe MB, Dueck CA, Traub SA, Nicolson M, Manore MM et al. Adiposity, plasma leptin concentration and reproductive function in active and sedentary females. Int J Obes 1997; 21: 818-821.
14. 14 Kopp W, Blum WF, von Prittwitz S, Ziegler A, Lubbert H, Emons G et al. Low leptin levels predict amenorrhea in underweight and eating disordered females. Mol Psychiatry 1997; 2: 335-340.
15. 15 von Prittwritz S, Blum WF, Ziegler A, Scharmann S, Remschmidt H, Hebebrand J. Restrained eating is associated with a low leptin synthesis in underweight females. Mol Psychiatry 1997; 2: 420-422.
16. 16 Hebebrand J, Blum WF, Barth N, Coners H, Englaro P, Juul A et al. Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration. Mol Psychiatry 1997; 2: 330-334.
17. 17 WHO. Composite International Interview (CIDI): (a) CIDI Interview (version 1.0). (b) CIDI-user manual, (c) CIDI-training manual, (d) CIDI computer programs. WHO, Geneva.
18. 18 Lilliefors HW. On the Kolmogorov-Smirnov test for the exponential distribution with mean unknown. J Am Stat Assoc 1969; 64: 387-389.