Pharmacological basis for the empirical use of Eugenia uniflora L. (Myrtaceae) as antihypertensive

Journal of Ethnopharmacology

Volumn 66, Issue 1, 1999, Pages 33-39

  Consolini, Alicia E ^a   Baldini, Osvaldo A N ^a   Amat, Aníbal G ^b  

^a UNIVERSIDAD NACIONAL DE LA PLATA   (Argentina)

^b NONE

Author keywords

Diuretic; Eugenia uniflora L. (Myrtaceae); Hindquarters; Hypotensive; Ionic urine content; Vasodilator

Indexed keywords

AMILORIDE; ANTIHYPERTENSIVE AGENT; DIPEPTIDYL CARBOXYPEPTIDASE; EUGENIA UNIFLORA EXTRACT; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE REGULATION; CONTROLLED STUDY; DIURESIS; DRUG ISOLATION; ENZYME INHIBITION; ETHNOPHARMACOLOGY; FEMALE; INTRAGASTRIC DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY BLOOD FLOW; MALE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; RAT; VASODILATATION;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DIURETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; PLANT EXTRACTS; PLANTS, MEDICINAL; RATS; RATS, WISTAR; VASODILATOR AGENTS;

EID: 0033008530     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-8741(98)00194-9     Document Type: Article

References (21)

1. Adebajo A.C., Oloke K.J., Aladesanmi A.J. Antimicrobial activities and microbial transformation of volatile oils of Eugenia uniflora. Fitoterapia. 60(5):1989;451-455.
2. Amat A.G., Yajía M.E. Medicinal plants and ethnopharmacology in the province of Misiones (Argentina). Acta Farmacéutica Bonaerense. 10:1991;153-159.
3. Bandoni A.L., Mendiondo M.E., Rondina R.V.D., Coussio J.D. Survey of argentine medicinal plants. I. Folklore and phytochemical screening. Lloydia. 35:1972;69-80.
4. Bolton T.B. Mechanisms of action of transmitters and other substances on smooth muscle. Physiological Reviews. 59:1979;606-718.
5. Consolini A.E., Grand C.A. Nifedipine effect on perfusion pressure changes produced by α1-adrenergic agonists and depolarizing solution in rat hindquarters. Acta Physiologica Pharmacologica et Therapeutica Latino Americana. 41(2):1991;229-238.
6. Cummings J.P., Haynes J.D., Lipchuck L.M., Ronsberg M.A. A sequential probability ratio method for detecting compounds with diuretic activity in rats. Journal of Pharmacological and Experimental Therapeutics. 128:1960;414-418.
7. Edwards R.M., Trizna W., Kinter L.B. Renal microvascular effects of vasopressin and vasopressin antagonists. American Journal of Physiology. 256:1989;274-278.
8. Freis E.D. How diuretics lower blood pressure. American Heart Journal. 106:1983;185-187.
9. Karaki H., Ozaki H., Hori M. et al. Calcium movements, distribution, and functions in smooth muscle. Pharmacological Reviews. 49(2):1997;157-230.
10. Lang F. Osmotic diuresis. Renal Physiology. 10:1987;160-173.
11. Langer S.Z., Cavero I., Massingham R. Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents. Hypertension. 2:1980;372-382.
12. van Meel J.C.A., Timmermans P.B.M.W.M., van Zwieten P.A. α1- and α2-adrenoceptor stimulation in the isolated perfused hindquarters of the rat: an in vitro model. Journal of Cardiovascular Pharmacology. 5:1983;580-585.
13. Ratera E.E., Ratera M.O. Plantas de la Flora Argentina empleadas en Medicina Popular. 1980;128-129 Hemisferio Sur, Buenos Aires.
14. Rebuelta M., Vivas J.M., Baraibar C., Lazaro-Carrasco M.J. Estudio del efecto diurético de diferentes preparados de Betula celtiberica Rothm et Vasc. Anales de la Academia de Farmacia. 51:1985;103-112.
15. Retamar J.A. Aceites esenciales de especies vegetales diversas. Sus posibilidades químicas. I(II):1982;115-116 IPNAYS-CONICET, Santa Fe, Argentina.
16. Rotman A.D. Las especies argentinas del género Eugenia L. (Myrtaceae). Boletín de la Sociedad Argentina de Botánica. 30:1995;63-93.
17. Schmeda-Hirschmann G., Theoduloz C., Franco L., Ferro E., Rojas de Arias A. Preliminary pharmacological studies on Eugenia uniflora leaves: xanthine oxidase inhibitory activity. Journal of Ethnopharmacology. 21:1987;183-186.
18. Swales A.D., Thurstom H., Queiroz F.P., Medina A., Holland J. Dual mechanism for experimental hypertension. The Lancet. 27:1971;1181-1183.
19. Sybertz E., van der Bliet G., Baum T. Analysis of the vasoconstrictor responses to potassium depolarization and norepinephrine and their antagonism by differing classes of vasodilators in the perfused rat hindquarters. Journal of Pharmacology and Experimental Therapeutics. 227:1983;621-626.
20. ++ entry blockers in the pithed rat: arguments against the role of receptor reserve. Journal of Pharmacology and Experimental Therapeutics. 240(3):1987;864-870.
21. Yajía M.E., González C.F., Lorca C.L., Amat A.G., De Battista G.A., Sánchez González F. Toxicidad general y genotoxicidad de los extractivos de Eugenia uniflora L. (Myrtaceae). Anales de la Sociedad Argentina para la Investigación de Productos Aromáticos. 15:1997;229-237.