Stereoselective metabolism of tazofelone, an anti-inflammatory bowel disease agent, in rats and dogs and in human liver microsomes

Chirality

Volumn 11, Issue 3, 1999, Pages 233-240

  Clay, Michael P ^a   Hanssen, Brenda R ^a   Surapaneni, Sekhar S ^a,b   Lindstrom, Terry D ^a  

^a ELI LILLY AND COMPANY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Chiral inversion; Chiral sulfoxides; In vitro metabolism; Pharmacokinetics; Protein binding; Sulfoxidation

Indexed keywords

ANTIINFLAMMATORY AGENT; TAZOFELONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HALF LIFE; DRUG INDICATION; DRUG METABOLISM; DRUG STRUCTURE; ENTERITIS; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STEREOCHEMISTRY; STEREOSPECIFICITY;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BLOOD PROTEINS; DOGS; FEMALE; HALF-LIFE; HUMANS; INFLAMMATORY BOWEL DISEASES; INJECTIONS, INTRAVENOUS; MALE; MICROSOMES, LIVER; PHENOLS; PROTEIN BINDING; RATS; RATS, INBRED F344; STEREOISOMERISM; SULFOXIDES; THIAZOLES; THIAZOLIDINES;

EID: 0033008481     PISSN: 08990042     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1520-636X(1999)11:3<233::AID-CHIR10>3.0.CO;2-J     Document Type: Article

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