Binding affinity of sarpogrelate to 5-HT(2A) receptor ligand recognition sites in rat renal cortical and mesangial cells in culture

General Pharmacology

Volumn 33, Issue 1, 1999, Pages 51-57

  Nishio, Hiroaki ^a   Yoshikawa, Satoru ^b   Morimoto, Yukiko ^b   Chen, Zhiqing ^b   Nakata, Yoshihiro ^b  

^a FUKUYAMA UNIVERSITY   (Japan)

^b HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

5 HT(2A) receptors; 5 hydroxytryptamine; Ketanserin; Mesangial cells; Recognition sites; Sarpogrelate

Indexed keywords

4 IODO 2,5 DIMETHOXYAMPHETAMINE; KETANSERIN; METHYSERGIDE; MIANSERIN; RITANSERIN; SARPOGRELATE; SEROTONIN; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; KIDNEY CORTEX; MALE; MESANGIUM CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

2,5-DIMETHOXY-4-METHYLAMPHETAMINE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELLS, CULTURED; CEREBRAL CORTEX; GLOMERULAR MESANGIUM; KETANSERIN; KIDNEY CORTEX; MALE; MEMBRANES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SUBCELLULAR FRACTIONS; SUCCINATES; TRITIUM;

EID: 0033007363     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(98)00266-3     Document Type: Article

References (23)

1. 50) of an enzymatic reaction. Biochem Pharmacol 22, 3099-3108.
2. 2 sites in rabbit cerebral cortex and neostriatum. Neurochem Res 15, 507-514.
3. Endlich, K., Kuhn, R., Steinhausen, M., 1993. Visualization of serotonin effects on renal vessels of rats. Kidney Int 43, 314-323.
4. Eto, Y., Nitta, K., Uchida, K., Tsutsui, T., Natori, K., Kawashima, A., Yumura, W., Nihei, H., 1997. Anti-mitogenic effects of sarpogrelate in cultured rat mesangial cells. Life Sci 60, 193-199.
5. 1B receptor on CHO cells: functional responses in the absence of radioligand binding. Br J Pharmacol 117, 1119-1126.
6. 2+ responses in mesangial cells. Naunyn-Schmied Arch Pharmacol 356, 240-247.
7. Hoffman, B.J., 1994. Expression cloning of a serotonin transporter: a new way to study antidepressant drugs. Pharmacopsychiat 27, 16-22.
8. 2+ in cultured rat mesangial cells. Life Sci 55, 365-370.
9. Kurscheid-Reich, D., Throckmorton, D.C., Rasmussen, H., 1995. Serotonin activates phopholipase D in rat mesangial cells. Am J Physiol 268, 997-1003.
10. 2 recepor binding sites. Mol Pharmacol 21, 301-314.
11. 3H]ketanserin binding sites on human platelets and their role in serotonin release. Eur J Pharmacol 206, 39-45.
12. Mene, P., Pugliese, F., Cinotti, G.A., 1991. Serotonin and the glomerular mesangium. Mechanism of intracellular signaling. Hypertension 17, 151-160.
13. Montero, A., Rodriguez-Lopez, A., Reverte, M., Lopez-Novoa, J.M., 1995. The effect of LU-49938 (nexopamil) on the activation by serotonin of mesangial cells. Fundam Clin Pharmacol 9, 175-180.
14. 2A receptor. Am J Physiol 268, 122-127.
15. Nemecek, G.M., Coughlin, S.R., Handley, D.A., Moskovitz, M.A., 1986. Stimulation of aortic smooth muscle cell mitogenesis by serotonin. Proc Natl Acad Sci USA 83, 674-678.
16. Nishio, H., Inoue, A., Nakata, Y., 1996. Binding affinity of sarpogrelate, a new antiplatelet agent, and its metabolite for serotonin receptor subtypes. Arch Int Pharmacodyn Ther 331, 189-202.
17. Pazos, A., Cortes, R., Palacios, J.M., 1985. Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res 346, 231-249.
18. Roth, B.L., Nakai, T., Chuang D.-M., Costa, E., 1986. 5-Hydroxytryptamine-2 receptors coupled to phospholipase C in rat aorta: modulation of phosphoinositide turnover by phorbol ester. J Pharmacol Exp Ther 238, 480-485.
19. 1B receptors inhibiting cyclic AMP accumulation in rat renal mesangial cells. Naunyn-Schmied Arch Pharmacol 351, 35-39.
20. Sterzel, R.B., Lovett, D.H., Stein ,H.D., Kashgarian, M., 1982. The mesangium and glomerulonephritis. Klin Wochenschr 60, 1077-1092.
21. Takuwa, N., Ganz, M., Takuwa, Y., Sterzel, R.B., Rasmussen, H., 1989. Studies of the mitogenic effect of serotonin in rat renal mesangia 1 cells. Am J Physiol 257, 431-439.
22. Wolthuis, A., Boes, A., Rodemann, H.P., Grond, J., 1992. Vasoactive agents affect growth and protein synthesis of cultured rat mesangial cells. Kidney Int 41, 124-131.
23. Zifa, E., Fillion, G., 1992. 5-Hydroxytryptamine receptors. Pharmacol Rev 44, 401-458.