VEGF, VEGFR-1, VEGFR-2, microvessel density and endothelial cell proliferation in tumours of the ovary

International Journal of Cancer

Volumn 84, Issue 2, 1999, Pages 101-108

  Orre, Maxine ^a   Rogers, Peter A W ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

RECEPTOR SUBTYPE; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANGIOGENESIS; ARTICLE; CANCER STAGING; CELL PROLIFERATION; CELL TYPE; CONTROLLED STUDY; CORRELATION FUNCTION; CYSTADENOMA; ENDOTHELIUM CELL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MITOSIS INDEX; OVARY TUMOR; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; TUMOR VASCULARIZATION;

ADENOCARCINOMA, MUCINOUS; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; CYSTADENOCARCINOMA, SEROUS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IN SITU HYBRIDIZATION; LYMPHOKINES; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; OVARIAN NEOPLASMS; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033007334     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19990420)84:2<101::AID-IJC2>3.0.CO;2-5     Document Type: Article

References (30)

1. ABU-JAWDEH, G.M., FAIX, J.D., NILOFF, J., TOGNAZZI, K., MANSEAU, E., DVORAK, H.F. and BROWN, L.F., Strong expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in ovarian borderline and malignant neoplasms. Lab. Invest., 74, 1105-1115 (1996).
2. AHMED, A., LI, X.F., DUNK, C., WHITTLE, M.J., RUSHTON, D.I. and ROLLASON, T., Colocalisation of vascular endothelial growth factor and its Flt-1 receptor in human placenta. Growth Factors, 12, 235-243 (1995).
3. AUERBACH, R., ARENSMAN, R., KUBAI, L. and FOLKMAN, J., Tumor-induced angiogenesis: lack of inhibition by irradiation. Int. J. Cancer, 26, 241-245 (1975).
4. BOOCOCK, C.A., CHARNOCK-JONES, D.S., SHARKEY, A.M., MCLAREN, J., BARKER, P.J., WRIGHT, K.A., TWENTYMAN, P.R. and SMITH, S.K., Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma. J. nat. Cancer Inst., 87, 506-516 (1995).
5. BROWN, L.F., DETMAR, M., TOGNAZZI, K., ABU-JAWDEH, G. and IRUELAARISPE, M.L., Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor/vascular endothelial growth factor. Lab. Invest., 76, 245-255 (1997).
6. CAO, Y., LINDEN, P., SHIMA, D., BROWNE, F. and FOLKMAN, J., In vivo angiogenic activity and hypoxia induction of heterodimers of placenta growth factor/vascular endothelial growth factor. J. clin. Invest., 98, 2507-2511 (1996).
7. DVORAK, H.F., BROWN, L.F., DETMAR, M. and DVORAK, A.M., Vascular permeability factor/vascular endothelial growth factor, microvascular hyper-permeability, and angiogenesis. Amer. J. Pathol., 146, 1029-1039 (1995).
8. FERRARA, N. and DAVIS-SMYTH, T., The biology of vascular endothelial growth factor. Endocr. Rev., 18, 4-25 (1997).
9. FOLKMAN, J., Tumor angiogenesis. Adv. Cancer Res., 43, 175-203 (1985).
10. FOX, S.B., GATTER, K.C., BICKNELL, R., GOING, J.J., STANTON, P., COOKE, T.G. and HARRIS, A.L., Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res., 53, 4161-4163 (1993).
11. GASPARINI, G., BONOLDI, E., VIALE, G., VERDERIO, P., BORACCHI, P., PANIZZONI, G.A., RADAELLI, U., DI BACCO, A., GUGLIELMI, R.B. and BEVILACQUA, P., Prognostic and predictive value of tumour angiogenesis in ovarian carcinomas. Int. J. Cancer, 69, 205-211 (1996).
12. GITAY-GOREN, H., HALABAN, R. and NEUFELD, G., Human melanoma cells but not normal melanocytes express vascular endothelial growth factor receptors. Biochem. biophys. Res. comm., 190, 702-708 (1993).
13. ORRE, M., LOTFI-MIRI, M., MAMERS, P. and ROGERS, P.A.W., Increased microvessel density in mucinous compared with malignant serous and benign tumours of the ovary. Brit. J. Cancer, 77, 2204-2209 (1998).
14. REYNOLDS, K., FARZANEH, F., COLLINS, W.P., CAMPBELL, S., BOURNE, T.H., LAWTON, F., MOGHADDAM, A., HARRIS, A.L. and BICKNELL, R., Association of ovarian malignancy with expression of platelet-derived endothelial cell growth factor. J. nat. Cancer Inst., 86, 1234-1238 (1994).
15. ROBERTS, W.G. and PALADE, G.E., Neovasculature induced by vascular endothelial growth factor is fenestrated. Cancer Res., 57, 765-772 (1997).
16. SHOLLEY, M.M., FERGUSON, G.P., SEIBEL, H.R., MONTOUR, J.L. and WILSON, J.D., Mechanisms of neovascularization. Vascular sprouting can occur without proliferation of endothelial cells. Lab. Invest., 51, 624-634 (1984).
17. SIMORRE-PINATEL, V., GUERRIN, M., CHOLLET, P., PENARY, M., CLAMENS, S., MALECAZE, F. and PLOUET, J., Vasculotropin-VEGF stimulates retinal capillary endothelial cells through an autocrine pathway. Invest. Ophthalmol. Vis. Sci., 35, 3393-3400 (1994).
18. STOKES, C.L., Endothelial cell migration and chemotaxis in angiogenesis. EXS, 61, 118-124 (1992).
19. TAKAHASHI, Y., KITADAI, Y., BUCANA, C.D., CLEARY, K.R. and ELLIS, L.M., Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res., 55, 3964-3968 (1995).
20. TOI, M., INADA, K., SUZUKI, H. and TOMINAGA, T., Tumor angiogenesis in breast cancer: its importance as a prognostic indicator and the association with vascular endothelial growth factor expression. Breast Cancer Res. Treat., 36, 193-204 (1995).
21. UNEMORI, E.N., FERRARA, N., BAUER, E.A. and AMENTO, E.P., Vascular endothelial growth factor induces interstitial collagenase expression in human endothelial cells. J. cell. Physiol., 153, 557-562 (1992).
22. VARTANIAN, R.K. and WEIDNER, N., Correlation of intratumoral endothelial cell proliferation with microvessel density (tumor angiogenesis) and tumor cell proliferation in breast carcinoma. Amer. J. Pathol., 144, 1188-1194 (1994).
23. VARTANIAN, R.K. and WEIDNER, N., Endothelial cell proliferation in prostatic carcinoma and prostatic hyperplasia: correlation with Gleason's score, microvessel density, and epithelial cell proliferation. Lab. Invest., 73, 844-850 (1995).
24. VERMEULEN, P.B., VERHOEVEN, D., HUBENS, G., VAN MARCK, E., GOOVAERTS, G., HUYGHE, M., DE BRUIJN, E.A., VAN OOSTEROM, A.T. and DIRIX, L.Y., Microvessel density, endothelial cell proliferation and tumour cell proliferation in human colorectal adenocarcinomas. Ann. Oncol., 6, 59-64 (1995).
25. WALTENBERGER, J., CLAESSON-WELSH, L., SIEGBAHN, A., SHIBUYA, M. and HELDIN, C.H., Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. biol. Chem., 269, 26988-26995 (1994).
26. WATANABE, Y. and DVORAK, H.F., Vascular permeability factor/vascular endothelial growth factor inhibits anchorage-disruption-induced apoptosis in microvessel endothelial cells by inducing scaffold formation. Exp. Cell Res., 233, 340-349 (1997).
27. 121 induces proliferation of vascular endothelial cells and expression flk-1 without affecting lymphatic vessels of the chorioallantoic membrane. Develop. Biol., 176, 76-85 (1996).
28. YAMAMOTO, S., KONISHI, I., MANDAI, M., KURODA, H., NANBU, K., SAKAHARA, H. and MORI, T., Expression of vascular endothelial growth factor (Vegf) in epithelial ovarian neoplasms - correlation with clinicopathology and patient survival, and analysis of serum vegf levels. Brit. J. Cancer, 11, 1221-1227 (1997).
29. YEO, K.T., WANG, H.H., NAGY, J.A., SIOUSSAT, T.M., LEDBETTER, S.R., HO-OGEWERF, A.J., ZHOU, Y., MASSE, E.M., SENGER, D.R. and DVORAK, H.F., Vascular permeability factor (vascular endothelial growth factor) in guinea pig and human tumor and inflammatory effusions. Cancer Res., 53, 2912-2918 (1993).
30. YU, C.C. and FILIPE, M.I., Update on proliferation-associated antibodies applicable to formalin-fixed paraffin-embedded tissue and their clinical applications. Histochem. J., 25, 843-853 (1993).