Comparison of intraocular pressure lowering by topical and systemic carbonic anhydrase inhibitors in the rabbit

Journal of Ocular Pharmacology and Therapeutics

Volumn 15, Issue 1, 1999, Pages 51-57

  Fanous, Maher M ^a   Challa, Pratap ^b   Maren, Thomas H ^b  

^a Ophthalmology and Visual Science Research Center   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGLAUCOMA AGENT; CARBONATE DEHYDRATASE INHIBITOR; DORZOLAMIDE; SEZOLAMIDE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GLAUCOMA; INTRAOCULAR PRESSURE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RABBIT; TONOMETRY; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0033006905     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1999.15.51     Document Type: Article

References (18)

1. Maren, T.H., Jankowska, L., Sanyal, G., and Edelhauser, H.F. The transcorneal permeability of sulfonamide carbonic anhydrase inhibitors and their effect on aqueous humor secretion. Exp. Eye Res. 36:457-480, 1983.
2. Maren, T.H., Bar-Ilan, A., Conroy, C.W., and Brechue, W.F. Chemical and pharmacological properties of MK-927, a sulfonamide carbonic anhydrase inhibitor that lowers intraocular pressure by the topical route. Exp. Eye Res. 50:27-36, 1990.
3. Sugrue, M.F., Gautheron, P., Grove, J., et al. MK-927: A topically active ocular hypotensive carbonic anhydrase inhibitor. J. Ocular Pharmacol. 6:9-22, 1990.
4. Sugrue, M.F., Gautheron, P., Mallorga, P., et al. L-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals. Br. J. Pharmacol. 99:59-64, 1990.
5. Brechue, W.F. and Maren, T.H. Carbonic anhydrase inhibitory activity and ocular pharmacology of organic sulfamates. J. Pharmacol. Exp. Ther. 264:670-675, 1993.
6. Brechue, W.F. and Maren, T.H. pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors. Invest. Ophthalmol. Vis. Sci. 34:2581-2587, 1993.
7. Lippa, E.A., von Denffer, H.V., Hoffman, H.M., and Brunner-Ferber, F.L. Local tolerance and activity of MK-927, a novel carbonic anhydrase inhibitor. Arch. Ophthalmol. 106:1694-1696, 1988.
8. Pfeiffer, N., Hennekes, R., Lippa, E.A., Grehn, F., Garus, H., and Brunner-Ferber, F.L. A single dose of the topical carbonic anhydrase inhibitor MK-927 decreases IOP in patients. Br. J. Ophthalmol. 74:405-408, 1990.
9. Bar-Ilan, A. Diurnal and seasonal variations in intraocular pressure in the rabbit. Exp. Eye Res. 39:175-181, 1984.
10. Maren, T.H. Basic Sciences in Clinical Glaucoma. The development of topical carbonic anhydrase inhibitors. J. Glaucoma 4:49-62, 1995.
11. Maren, T.H., Haywood, J.R., Chapman, S.K., and Zimmerman, T.J. The pharmacology of methazolamide in relation to the treatment of glaucoma. Invest. Ophthalmol. Vis. Sci. 16:730-742, 1977.
12. Maren, T.H., Brechue, W.F., and Bar-Ilan, A. Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. Exp. Eye Res. 55:73-79, 1992.
13. Brechue, W.F., Kinne-Saffran, E., Kinne, R.K.H., and Maren, T.H. Localization and activity of renal carbonic anhydrase (CA) in CA-II deficient mice. Biochim. Biophysica Acta 1066:201-207, 1991.
14. Wistrand, P.J. Distribution and function of carbonic anhydrase (CA) isoenzymes in the human eye. Relevance for the design of topical CA inhibitors. Abstract presented at the Int. Congress for Eye Res., Stresa, Italy, 1992.
15. Ridderstrale, Y., Wistrand, P.J., and Brechue, W.F. Membrane-associated CA activity in the eye of the CA-II deficient mouse. Invest. Ophthalmol. Vis. Sci. 35:2577-2584, 1994.
16. Conroy, C.W. and Maren, T.H. The effect of temperature on the binding of sulfonamides to carbonic anhydrase isozymes I, II, and IV. Mol. Pharmacol. 48:486-491, 1995.
17. Maus, T.L., Larson, L., McLaren, J.W., and Brubaker, R.F. Comparison of dorzolamide and acetazolamide as suppressors of aqueous humor flow in humans. Arch. Ophthalmol. 115:45-49, 1997.
18. Edelhauser, H.F. and Maren, T.H. Permeability of human cornea and sclera to sulfonamide carbonic anhydrase inhibitors. Arch. Ophthalmol. 106:1110-1115, 1988.