Insertion/deletion angiotensin converting enzyme gene polymorphism affects the microvascular structure of the kidney in patients with nondiabetic renal disease

Journal of Hypertension

Volumn 17, Issue 3, 1999, Pages 351-356

  Teranishi, Megumi ^a   Ono, Hidehiko ^a   Ishimitsu, Toshihiko ^a   Matsuoka, Hiroaki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Angiotensin converting enzyme; Gene polymorphism; Renal disease; Vascular hypertrophy; Vascular wall thickening

Indexed keywords

CREATININE; DIPEPTIDYL CARBOXYPEPTIDASE; HORMONE;

ADULT; ANGIOTENSIN BLOOD LEVEL; ARTERIOLE; ARTERY WALL; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL WALL; CARDIOVASCULAR RISK; CHROMOSOME INSERTION; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; GENE DELETION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOGLOBULIN A NEPHROPATHY; INTERSTITIUM; KIDNEY BIOPSY; KIDNEY BLOOD VESSEL; KIDNEY DISEASE; MAJOR CLINICAL STUDY; MALE; MICROVASCULATURE; POLYMERASE CHAIN REACTION; PRESSURE; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RISK FACTOR;

EID: 0033006382     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199917030-00007     Document Type: Article

References (22)

1. 1 Schunkert H, Hense H-W, Holmer SR, Stender M, Perz S, Keil U, et al. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. N Engl J Med 1994; 330:1634-1638.
2. 2 Nakai K, Itoh C, Miura Y, Hotta K, Musha T, Itoh T, et al. Deletion polymorphism of the angiotensin I-converting enzyme gene is associated with serum ACE concentration and increased risk for CAD in the Japanese. Circulation 1994; 90:2199-2202.
3. 3 Hunley TE, Julian BA, Phillips JA III, Summar ML, Yoshida H, Horn RG, et al. Angiotensin converting enzyme gene polymorphism: potential silencer motif and impact on progression in Ig A nephropathy. Kidney Int 1996; 49:571-577.
4. 4 Harden PN, Geddes C, Rowe PA, McIlroy JH, Boulton-Jones M, Rodger RSC, et al. Polymorphisms in angiotensin-converting enzyme gene and progression of IgA nephropathy. Lancet 1995; 345:1540-1542.
5. 5 Yoshida H, Mitarai T, Kawamura T, Kitajima T, Miyazaki Y, Nagasawa R, et al. Role of the deletion polymorphism of the angiotensin converting enzyme gene in the progression and therapeutic responsiveness of IgA nephropathy. J Clin Invest 1995; 96:2162-2169.
6. 6 Hosoi M, Nishizawa Y, Kogawa K, Kawagishi T, Konishi T, et al. Angiotensin-converting enzyme gene polymorphism is associated with carotid arterial wall thickness in non-insulin-dependent diabetic patients. Circulation 1996; 94:704-707.
7. 7 Castellano M, Muiesan ML, Rizzoni D, Beschi M, Pasini G, Cinelli A. Angiotensin-converting enzyme I/D polymorphism and arterial wall thickness in a general population: the Vobarno study. Circulation 1995; 91:2721-2724.
8. 8 Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 1990; 86:1343-1346.
9. 9 Tiret L, Rigat B, Visvikis S, Breda C, Corvol P, Cambien F, et al. Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 1992; 51:197-205.
10. 10 Paquet JL, Baudouin-Legros M, Brunelle G, Meyer P. Angiotensin II-induced proliferation of aortic myocytes in spontaneously hypertensive rats. J Hypertens 1990; 8:565-572.
11. 11 Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium: fibrosis and renin-angiotensin-aldosterone system. Circulation 1991; 83:1849-1865.
12. 12 Tsukada K, Ishimitsu T, Tsuchiya N, Horinaka S, Matsuoka H. Angiotensin-converting enzyme gene polymorphism and cardiovascular endocrine system in coronary angiography patients. Jpn Heart J 1997; 38:799-810.
13. 13 Ono H, Ono Y, Frohlich ED. Nitric oxide synthase inhibition in spontaneously hypertensive rats. Hypertension 1995; 26:249-255.
14. 14 Kakinuma Y, Kawamura T, Bills T, Yoshioka T, Ichikawa I, Fogo A. Blood pressure-independent effect of angiotensin inhibition on vascular lesions of chronic renal failure. Kidney Int 1992; 42:46-55.
15. 15 Bonithon-Kopp C, Ducimetiore P, Touboul P-J, Feve J-M, Billaud E, Courbon D, et al. Plasma angiotensin-converting enzyme activity and carotid wall thickening. Circulation 1994; 89:952-954.
16. 16 Naftilan AJ, Pratt RE, Dzau VJ. Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells. J Clin Invest 1989; 83:1419-1424.
17. 17 Dzau VJ, Gibbons GH, Pratt RE. Molecular mechanisms of vascular renin-angiotensin system in myointimal hyperplasia. Hypertension 1991; 18 (Suppl II):II100-II105.
18. 18 Jan Danser AH, Schalekamp MADH, Bax WA, Brink AMVD, Saxena PR, Riegger GAJ, et al. Angiotensin-converting enzyme in the human heart: effect of the deletion/insertion polymorphism. Circulation 1995; 92:1387-1388.
19. 19 Dahlöf B, Pennert K, Hansson L. Reversal of left ventricular hypertrophy in hypertensive patients: a meta-analysis of 109 treatment studies. Am J Hypertens 1992; 5:95-110.
20. 20 Missouris CG, Barley J, Jeffery S, Carter ND, Singer DRJ, MacGregor GA. Genetic risk for renal artery stenosis: association with deletion polymorphism in angiotensin 1-converting enzyme gene. Kidney Int 1996; 49:534-537.
21. 21 Farhy RD, Ho K-L, Carretero OA, Scicli AG. Kinins mediate the antiproliferative effect of ramipril in rat carotid artery. Biochem Biophys Res Commun 1992; 182:283-288.
22. 22 Linz W, Wiemer G, Scholkens BA. Bradykin prevents left ventricular hypertrophy in rats. J Hypertens 1993; 11 (Suppl 5):S96-S97.