Continuous and intermittent itraconazole dosing schedules for the treatment of onychomycosis: A pharmacokinetic comparison

British Journal of Dermatology

Volumn 140, Issue 1, 1999, Pages 96-101

  Havu, V ^a   Brandt, H ^b   Heikkila, H ^c   Hollmen, A ^d   Oksman, R ^a   Rantanen, T ^e   Saari, S ^a   Stubb, S ^c   Turjanmaa, K ^f   Piepponen, T ^g  

^a TURKU UNIVERSITY HOSPITAL   (Finland)

^b Helsingin Laakarikeskus   (Finland)

^c HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^d Vuorikadun Laakariasema   (Finland)

^e Savonlinna Central Hospital   (Finland)

^f Koskiklinikka   (Finland)

^g Department of Clinical Research   (Finland)

Author keywords

Continuous and intermittent dosing; Itraconazole; Onychomycosis

Indexed keywords

HYDROXYITRACONAZOLE; ITRACONAZOLE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG INTERMITTENT THERAPY; DRUG TISSUE LEVEL; FEMALE; FINGER NAIL; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; ONYCHOMYCOSIS; ORAL DRUG ADMINISTRATION; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TOE;

ADOLESCENT; ADULT; ANTIFUNGAL AGENTS; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; ITRACONAZOLE; MALE; MIDDLE AGED; ONYCHOMYCOSIS;

EID: 0033006343     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1999.02614.x     Document Type: Article

References (20)

1. Zaias N. Onychomycosis. Dermatol Clin 1985; 3: 445-60.
2. Ramesh V, Reddy BSN, Singh R. Onychomycosis. Int J Dermantol 1983; 22: 148-52.
3. André J, Achten G. Onychomycosis. Int J Dermatol 1987; 26: 481-90.
4. Davies RR, Everall JD, Hamilton E. Mycological and clinical evaluation of griseofulvin for chronic onychomycosis. Br Med J 1967; iii: 464-8.
5. Cauwenbergh G, De Doncker P, Stoops K et al. Itraconazole in the treatment of human mycoses: Review of three years of clinical experience. Rev Infect Dis 1987; 9 (Suppl. 1): S146-52.
6. Delescluse J, Cauwenbergh G, Degreef H. Itraconazole, a new orally active antifungal, in the treatment of pityriasis versicolor. Br J Dermatol 1986; 114: 701-3.
7. Degreef H. Onychomycosis. Br J Clin Pract 1990; 44 (Suppl. 9): 91-7.
8. Van Cutsem J, van Gerven F, Janssen PAJ. Activity of orally, topically, and parenterally administered itraconazole in the treatment of superficial and deep mycoses: Animal models. Rev Infect Dis 1987; 9 (Suppl. 1): S15-32.
9. Van Cutsem J. The in-vitro antifungal spectrum of itraconazole. Mycoses 1989; 32 (Suppl. 1): 7-13.
10. Van Cutsem J. Oral and parenteral treatment with itraconazole in various superficial and systemic experimental fungal infections. Comparisons with other antifungals and combination therapy. Br J Clin Pract 1990; 44 (Suppl. 9): 32-40.
11. Van Cutsem J. van Gerven F, Janssen PAJ. The in vitro and in vivo antifungal activity of itraconazole. In: Recent Trends in the Discovery. Development and Evaluation of Antifugal Agents (Fromtling RA, ed.). Barcelona: JR Prous. 1987; 177-92.
12. Cauwenbergh G, Degreef H, Heykants J et al. Pharmacokinetic profile of orally administered itraconazole in human skin. J Am Acad Dermatol 1988; 18: 263-8.
13. Heykants J, van Peer A, de Velde V et al. The clinical pharmacokinetics of itraconazole: An overview. Mycoses 1989; 32 (Suppl. 1): 67-87.
14. Matthieu L, De Doncker P, Cauwenbergh G et al. Itraconazole penetrates the nail via the nail matrix and the nail bed - An investigation in onychomycosis. Clin Exp Dermatol 1991; 16: 374-6.
15. Willemsen M, De Doncker P, Willems J et al. Posttreatment itraconazole levels in the nail. New implications for treatment in onychomycosis. J Am Acad Dermatol 1992; 26: 731-5.
16. Havu V, Brandt H, Heikkila H et al. A double-blind, randomized study comparing itraconazole pulse therapy with continuous dosing for the treatment of toe-nail onychomycosis. Br J Dermatol 1997; 136: 230-4.
17. Woestenborghs R, Lorreyne W, Heykants J. Determination of itraconazole in plasma and animal tissues by high-performance liquid chromatography. J Chromatogr 1987; 413: 332-7.
18. Gupta AK, De Doncker P, Scher RK et al. Itraconazole for the treatment of onychomycosis. Int J Dermatol 1998; 37: 303-8.
19. van Doorslaer EKA, Tormans G, Gupta AK et al. Economic evaluation of antifungal agents in the treatment of toenail onychomycosis in Germany. Dermatology 1996: 193: 239-44.
20. Nolting SK, Sanchez Carazo J, De Boule K, Lambert JR. Oral treatment schedules for onychomycosis: A study of patient preference. Int J Dermatol 1998; 57: 454-6.