Phospholamban is present in endothelial cells and modulates endothelium- dependent relaxation evidence from phospholamban gene-ablated mice

Circulation Research

Volumn 84, Issue 3, 1999, Pages 360-364

  Sutliff, Roy L ^a   Hoying, James B ^a   Kadambi, Vivek J ^a   Kranias, Evangelia G ^a   Paul, Richard J ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b NONE   (United States)

Author keywords

Ca2+; Endothelium; Phospholamban; SERCA; Vasorelaxation

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); FORSKOLIN; PHOSPHOLAMBAN;

ANIMAL TISSUE; AORTA; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; FEMALE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE TONE; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0033006097     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.84.3.360     Document Type: Article

References (18)

1. Newby AC, Henderson AH. Stimulus-secretion coupling in vascular endothelial cells. Annu Rev Physiol. 1990;52:661-674.
2. 2+)-influx pathway. Biochem J. 1992;284:521-530.
3. Colden-Stanfield M, Schilling WP, Ritchie AK, Eskin SG, Navarro LT, Kunze DL. Bradykinin-induced increases in cytosolic calcium and ionic currents in cultured bovine aortic endothelial cells. Circ Res 1987;61: 632-640.
4. 2+ entry in freshly isolated rabbit aortic endothelial cells. Biochem Biophys Res Commun. 1997;241:471-475.
5. Kadambi VJ, Kranias EG. Phospholamban: a protein coming of age. Biochem Biophys Res Commun. 1997;239:1-5.
6. Luo W, Grupp IL, Harrer J, Ponniah S, Grupp G, Duffy JJ, Doetschman T, Kranias EG. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Circ Res. 1994;75:401-409.
7. Slack JP, Grupp IL, Luo W, Kranias EG. Phospholamban ablation enhances relaxation in the murine soleus. Am J Physiol. 1997;273:C1-C6.
8. Lalli J, Harrer JM, Luo W, Kranias EG, Paul RJ. Targeted ablation of the phospholamban gene is associated with a marked decrease in sensitivity in aortic smooth muscle. Circ Res. 1997;80:506-513.
9. 2+-ATPase isoform 3. J Biol Chem. 1997;272:30538-30545.
10. Kamata K, Miyata N, Kasuya Y. Involvement of endothelial cells in relaxation and contraction responses of the aorta to isoproterenol in naive and streptozotocin-induced diabetic rats. J Pharmacol Exp Ther 1989; 249:890-894.
11. Graves J, Poston L. β-Adrenoceptor agonist mediated relaxation of rat isolated resistance arteries: a role for the endothelium and nitric oxide. Br J Pharmacol. 1993;108:631-637.
12. Gray DW, Marshall I. Novel signal transduction pathway mediating endothelium-dependent β-adrenoceptor vasorelaxation in rat thoracic aorta. Br J Pharmacol. 1992;107:684-690.
13. Tada M, Kirchberger MA, Katz AM. Phosphorylation of a 22,000-dalton component of the cardiac sarcoplasmic reticulum by adenosine 3′:5′-monophosphate-dependent protein kinase. J Biol Chem 1975;250-2640-2647.
14. Lorenz JN, Kranias EG. Regulatory effects of phospholamban on cardiac function in intact mice. Am J Physiol. 1997;273:H2826-H2831.
15. Luo W, Wolska BM, Grupp IL, Harrer JM, Haghighi K, Ferguson DG, Slack JP, Grupp G, Doetschman T, Solaro RJ, Kranias EG. Phospholamban gene dosage effects in the mammalian heart. Circ Res 1996;78-839-847.
16. Kadambi VJ, Ponniah S, Harrer JM, Hoit BD, Dorn GW 2nd, Walsh RA, Kranias EG. Cardiac-specific overexpression of phospholamban alters calcium kinetics and resultant cardiomyocyte mechanics in transgenic mice. J Clin Invest. 1996;97:533-539.
17. Santana LF, Kranias EG, Lederer WJ. Calcium sparks and excitation-contraction coupling in phospholamban-deficient mouse ventricular myocytes. J Physiol (Lond). 1997;503:21-29.
18. Paul RJ. The role of phospholamban and SERCA3 in regulation of smooth muscle-endothelial cell signalling mechanisms: evidence from gene-ablated mice. Acta Physiol Scand. 1998;164:589-597.