Effect of deramciclane, a new 5-HT receptor antagonist, on cholecystokinin-induced changes in rat gastrointestinal function

European Journal of Pharmacology

Volumn 367, Issue 2-3, 1999, Pages 315-323

  Varga, Gábor ^a,b   Kordás, Krisztina ^a   Burghardt, Beáta ^a   Gacsályi, István ^c   Szénási, Gábor ^c  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c EGIS PHARMACEUTICALS LTD   (Hungary)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT receptor; CCK (cholecystokinin); Gallbladder; Gastric emptying; Pancreas

Indexed keywords

CHOLECYSTOKININ; CHOLECYSTOKININ RECEPTOR; DERAMCICLANE FUMARATE; LORGLUMIDE; SEROTONIN 2A RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GALLBLADDER; GALLBLADDER EMPTYING; GASTROINTESTINAL TRACT FUNCTION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; STOMACH EMPTYING;

ANIMALS; BORNANES; CHOLECYSTOKININ; DIGESTIVE SYSTEM; GALLBLADDER EMPTYING; GASTRIC EMPTYING; HORMONE ANTAGONISTS; MALE; MICE; PANCREAS; PROGLUMIDE; RATS; RATS, WISTAR; SEROTONIN ANTAGONISTS; TEMPORAL ARTERITIS;

EID: 0033004821     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00958-3     Document Type: Article

References (44)

1. Berger Z., Fehér E. Degeneration of intrapancreatic nerve fibers after chronic alcohol administration in mice. Int. J. Pancreatol. 21(2):1997;165-171.
2. Bernfeld, P., 1955. Amylases, alpha end beta. In: Colowick, S.P., Kaplan, N.O. (Eds.), Methods in Enzymology, Vol. I. Academic Press, New York, 149-158.
3. Bertaccini, G., 1982. Gastrointestinal hormones. In: Bertaccini, G. (Ed.), Handbook of Experimental Pharmacology, Vol. 59. Springer, Berlin, 11-83.
4. Bonhaus D.W., Bach C., DeSouza A., Salazar F.H., Matsuoka B.D., Zuppan P., Chan H.W., Eglen R.M. The pharmacology and distribution of human 5-hydroxytryptamine2B(5-HT2B) receptor gene products: comparison with 5-HT2A and 5-HT2C receptors. Br. J. Pharmacol. 115(4):1995;622-628.
5. Chey, W.Y., 1993. Hormonal control of pancreatic exocrine secretion. In: Go, V.L.W. et al. (Eds.), The Pancreas: Biology, Pathobiology and Disease. Raven Press, New York, 117-141.
6. Dockray, G.J., 1989. Comparative neuroendocrinology of gut peptides. In: Makhlouf, G.M. (Ed.), The Gastrointestinal System, Vol. 2. The American Physiological Society, New York, 133-170.
7. Douglas B.R., Woutersen R.A., Jansen J.B., Rovati L.C., Lamers C.B. Comparison of the effect of lorglumide on pancreatic growth stimulated by camostate in rat and hamster. Life Sci. 46:1990;281-286.
8. Fölsch U.R. Regulation of pancreatic growth. Clin. Gastroenterol. 13:1984;679-699.
9. Gacsályi I., Gyertyán I., Petocz L., Budai Z. Psychopharmacology of a new anxiolytic agent EGYT-3886. Pharmacol. Res. Commun. 20(1):1988;115-116.
10. Gacsályi I., Gigler G., Szabados T., Kovács A., Vasar E., Lang A., Mannistö P.T. Different antagonistic activity of deramciclane (EGIS-3886) on peripherial and central 5-HT2 receptors. Pharm. Pharmacol. Lett. 6(2):1996;82-85.
11. Gacsályi I., Schmidt E., Gertyán I., Vasar E., Lang A., Haapalinna A., Fekete M., Hietala J., Syvalahati E., Mannistö R.T. Receptor binding profile and anxiolytic activity of deramciclane (EGIS-3886) in animal models. Drug Dev. Res. 40(4):1997;333-348.
12. Göke B., Printz H., Koop I., Rausch U., Richter G., Arnold R., Adler G. Endogenous CCK release and pancreatic growth in rats after feeding a proteinase inhibitor (camostate). Pancreas. 1:1986;509-515.
13. Green T., Dimaline R., Peikin S., Dockray G.J. Action of the cholecystokinin antagonist L-364,718 on gastric emptying in the rat. Am. J. Physiol. 255:1988;G685-G689.
14. Gully D., Frehel D., Marcy C., Spinazze A., Lespy L., Neliat G., Maffrand J.P., Le Fur G. Peripheral biological activity of SR 27897: a new potent non-peptide antagonist of CCK(A) receptors. Eur. J. Pharmacol. 232:1993;13-19.
15. Hölzer H.H., Turkelson C.M., Solomon T.E., Raybould H.E. Intestinal lipid inhibits gastric emptying via CCK and a vagal capsaicin-sensitive afferent pathway in rats. Am. J. Physiol. 267:1994;G625-G629.
16. Hummel B.C. A modified spectrophotometric method for determination of chymotrypsin trypsin and thrombin. Can. J. Biochem. Physiol. 37:1959;1393-1399.
17. Kirchgessner A.L., Liu M.T., Raymond J.R., Gershon M.D. Identification of cells that express 5-hydroxytryptamine1A receptors in the nervous systems of the bowel and pancreas. J. Comp. Neurol. 364(3):1996;439-455.
18. Kuemmerle J.F., Murthy K.S., Grider J.R., Martin D.C., Makhlouf G.M. Coexpression of 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells. Gastroenterology. 109(6):1995;1791-1800.
19. Labarca C., Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal. Biochem. 102:1980;344-352.
20. Li Y., Hao Y., Owyang C. Evidence for autoregulation of cholecystokinin secretion during diversion of bile pancreatic juice in rats. Gastroenterology. 109:1995;231-238.
21. Li Y., Owyang C. Peptone stimulates CCK-releasing peptide secretion by activating intestinal submucosal cholinergic neurons. J. Clin. Invest. 97(6):1996;1463-1470.
22. Li Y., Hoa Y., Owyang C. CCK-releasing peptide mediates oleic acid stimulated secretion of CCK: involvement of intestinal submucosal cholinergic neurons. Regul. Peptides. 64:1996;110.
23. Liddle, R.A., 1994. Cholecystokinin. In: Walsh, J.H., Dockray, G.J. (Eds.), Gut Peptides: Biochemistry and Physiology. Raven Press, New York, 175-216.
24. Louie D.S., May D., Miller P., Owyang C. Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am. J. Physiol. 250:1986;G252-G259. Gastrointest. Liver Physiol. 13.
25. Lu L., Louie D., Owyang C. A cholecystokinin releasing peptide mediates feedback regulation of pancreatic secretion. Am. J. Physiol. 256:1989;G430-G435.
26. Makovec F., Bani M., Cereda R., Chiste R., Pacini M.A., Revel L., Rovati L.A., Rovati L.C., Setnikar I. Pharmacological properties of lorglumide as a member of a new class of cholecystokinin antagonists. Arzneimittelforschung. 37(II):1987;1265-1268.
27. Makovec F., Bani M., Cereda R., Chiste R., Pacini M.A., Revel L., Rovati L.C. Antispasmodic activity on the gallbladder of the mouse of CR 1409 (lorglumide) a potent antagonist of peripheral CCK. Pharmacol. Res. Com. 19:1987;41-51.
28. Mayer, E.A., 1994. The physiology of gastric storage and emptying. In: Johnson, L.R. et al. (Eds.), Physiology of the Gastrointestinal Tract, 3rd edn. Raven Press, New York, 929-976.
29. Miller L.J. Characterization of cholecystokinin receptors on human gastric smooth muscle tumors. Am. J. Physiol. 247:1984;G402-G410.
30. Miyasaka K., Guan D., Liddle R.A., Green G.M. Feedback regulation by trypsin: evidence for intraluminal CCK releasing peptide. Am. J. Physiol. 256:1989;G175-G181.
31. O'Rourke M.F., Reidelberger R.D., Solomon T.E. Effect of CCK antagonist L 364718 on meal-induced pancreatic secretion in rats. Am. J. Physiol. 258:1989;G179-G184. Gastrointest. Liver Physiol. 21.
32. Reidelberger R.D., Varga G., Liehr R.M., Castellanos D.A., Rosenquist G.L., Wong H.C., Walsh J.H. Cholecystokinin suppresses food intake by a non-endocrine mechanism in rats. Am. J. Physiol. 267:1994;R901-R908.
33. Scarpignato C., Varga G., Dobronyi I., Papp M. Effect of a new potent CCK antagonist, lorglumide, on caerulein- and bombesin-induced pancreatic secretion and growth in the rat. Br. J. Pharmacol. 96:1989;661-669.
34. Scarpignato C., Varga G., Corradi C. Effect of CCK and its agonists on gastric emptying. J. Physiol. 87:1993;291-300.
35. Schmidt W.E., Stockmann F., Choudhury A.R., Wilms H.M., Siegel E.G., Nustede R., Folsch U.R., Creutzfeldt W. Influence of CCK antagonist L-364,718, pancreastatin (33-49) and a somatostatin analogue on camostate-induced rat pancreatic hypertrophy. Digestion. 44:1989;105-116.
36. Sha L., Ou L.L., Miller S.M., Ma R., Szurszewski J.H. Cat pancreatic neurons: morphology, electrophysiological properties, and responses to 5-HT. Pancreas. 13(2):1996;111-124.
37. Solomon, T.E., 1981. Regulation of exocrine pancreatic cell proliferation and enzyme synthesis. In: Johnson, L.R. et al. (Eds.), Physiology of the Gastrointestinal Tract. Raven Press, New York, 873-892.
38. Solomon T.E., Petersen H., Elashoff J., Grossman T.E. Interaction of caerulein and secretin on pancreatic size and composition in rat. Am. J. Physiol. 235:1978;E714-E719.
39. Varga G., Reidelberger R.D., Lieh R.-M., Bussjaeger L.J., Coy D.H., Solomon T.E. Effects of potent bombesin antagonist on exocrine pancreatic secretion in rats. Peptides. 12:1991;493-497.
40. Varga G., Liehr R.-M., Scarpignato C., Coy D.H. Distinct receptors mediate gastrin-releasing peptide and neuromedin B induced delay of gastric emptying of liquids in rats. Eur. J. Pharmacol. 286:1995;109-112.
41. Varga G., Scarpignato C. Camostate and caerulein-induced delay of gastric emptying in the rat: effect of CCK-receptor antagonists. Eur. J. Pharmacol. 306:1996;153-159.
42. Varga G., Kisfalvi K., D'Amato M., Scarpignato C. Different actions of CCK on pancreatic and gastric growth in the rat: effect of CCK-A receptor blockade. Br. J. Pharmacol. 124:1998;435-440.
43. Wisner J.R., McLaughlin R.E., Rich K.A., Ozawa S., Renner I.G. Effects of L-364,718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas. Gastroenterology. 94:1988;109-113.
44. Woodruff G.N., Hughes J. Cholecystokinin antagonists. Annu. Rev. Pharmacol. Toxicol. 31:1991;469-501.