Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potentialantidepressant drugs

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 7, 1999, Pages 1349-1359

  Corral, Carlos ^a   Lissavetzky, Jaime ^a   Manzanares, Ignacio ^a   Darias, Victoriano ^b   Expósito Orta, María A ^b   Martín Conde, José A ^b   Sánchez Mateo, C Carmen ^b  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSIDAD DE LA LAGUNA   (Spain)

Author keywords

Antidepressant; Pharmacology; Synthesis; Thiophene; Viloxazine

Indexed keywords

ANTIDEPRESSANT AGENT; APOMORPHINE; IMIPRAMINE; PENTOBARBITAL; TETRABENAZINE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG; VILOXAZINE; VILOXAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; DRUG ACTIVITY; DRUG SYNTHESIS; HYPOTHERMIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCOMOTION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PTOSIS; SEDATION; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

5-HYDROXYTRYPTOPHAN; ANIMALS; ANTIDEPRESSIVE AGENTS; APOMORPHINE; BLEPHAROPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPOTHERMIA; IMIPRAMINE; LETHAL DOSE 50; MALE; MICE; MOVEMENT DISORDERS; PENTOBARBITAL; SLEEP; STRUCTURE-ACTIVITY RELATIONSHIP; TETRABENAZINE; VILOXAZINE;

EID: 0033004809     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00070-X     Document Type: Article

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