A gene for autosomal dominant hearing impairment (DFNA14) maps to a region on chromosome 4p16.3 that does not overlap the DFNA6 locus

Journal of Medical Genetics

Volumn 36, Issue 7, 1999, Pages 532-536

  Van Camp, Guy ^a   Kunst, Henricus ^b   Flothmann, Kris ^a   McGuirt, Wyman ^e   Wauters, Jan ^a   Marres, Henri ^b   Verstreken, Margriet ^a   Bespalova, Irina N ^c   Burmeister, Margit ^c   Van De Heyning, Paul H ^d   Smith, Richard J H ^e   Willems, Patrick J ^a   Cremers, Cor W R J ^b   Lesperance, Marci M ^c  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^e UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

DFNA14; DFNA6; Genetic linkage analysis; Non syndromic hearing impairment

Indexed keywords

ADULT; AGED; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CHROMOSOME 4P; CLINICAL ARTICLE; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; HAPLOTYPE; HEARING IMPAIRMENT; HUMAN; MALE; NETHERLANDS; PERCEPTION DEAFNESS; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGED; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; GENOTYPE; HAPLOTYPES; HEARING DISORDERS; HUMANS; LOD SCORE; MALE; MIDDLE AGED; PEDIGREE; PHENOTYPE;

EID: 0033004199     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Cohen MM, Gorlin RJ. Epidemiology, etiology, and genetic patterns. In: Gorlin RJ, Toriello HV, Cohen MM, eds. Hereditary hearing loss and its syndromes. Oxford: Oxford University Press, 1995:9-21.
2. Gorlin RJ. Genetic hearing loss with no associated abnormalities. In: Gorlin RJ, Toriello HV, Cohen MM, eds. Hereditary hearing loss and its syndromes. Oxford: Oxford University Press, 1995:43-61.
3. Prezant TR, Agapian JV, Bohlman MC, et al. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet 1993;4:289-94.
4. Reid FM, Vernham GA, Jacobs HT. A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness. Hum Mutat 1994;3:243-7.
5. Van Camp G, Willems PJ, Smith RJH. Nonsyndromic hearing impairment: unparalleled heterogeneity. Am J Hum Genet 1997;60:758-64.
6. Verhoeven K, Van Laer L, Kirschhofer K, et al. Mutations in the human α-tectorin gene cause autosomal dominant non-syndromic hearing impairment. Nat Genet 1998;19:60-2.
7. Jain PK, Fukushima K, Deshmukh D, et al. A human recessive neurosensory nonsyndromic hearing impairment locus is potential homologue of the murine deafness (dn) locus. Hum Mal Genet 1995;4:2391-4.
8. Scott DA, Carmi R, Elbedour K, et al. An autosomal recessive nonsyndromic-hearing-loss locus identified by DNA pooling using two inbred Bedouin kindreds, Am J Hum Genet 1996;59:385-91.
9. Kirschhofer K, Kenyon JB, Hoover DM, et al. Autosomal-dominant, prelingual, nonprogressive sensorineural hearing loss: localization of the gene (DFNA8) to chromosome 11q by linkage in an Austrian family. Cytogenet Cell Genet 1998;82:126-30.
10. Mustapha M, Chardenoux S, Nieder A, et al. A sensorineural progressive autosomal recessive form of isolated deafness, DFNB13, maps to chromosome 7q34-q36. Eur J Hum Genet (in press).
11. Chaib H, Lina-Granade G, Guilford P, et al. A gene responsible for a dominant form of neurosensory non-syndromic deafness maps to the NSRD1 recessive deafness gene interval. Hum Mol Genet 1994;3:2219-22.
12. Coucke P, Van Camp G, Djoyodiharjo B, et al. Linkage of autosomal dominant hearing loss to the short arm of chromosome 1 in two families. N Engl J Med 1994;331:425-31.
13. Van Camp G, Coucke P, Balemans W, et al. Localization of a gene for non-syndromic hearing loss (DFNA5) to chromosome 7p15. Hum Mol Genet 1995;4:2159-63.
14. Fagerheim T, Nilssen O, Raeymaekers P, et al. Identification of a new locus for autosomal dominant non-syndromic hearing impairment (DFNA7) in a large Norwegian family. Hum Mol Genet 1996;5:1187-91.
15. Manolis EN, Yandavi N, Nadol JB, et al. A gene for non-syndromic autosomal dominant progressive postlingual sensorineural hearing loss maps to chromosome 14q12-13. Hum Mol Genet 1996;5:1047-50.
16. Léon PE, Raventos H, Lynch E, et al. The gene for an inherited form of deafness maps to chromosome 5q31. Proc Natl Acad Sci USA 1992;89:5181-4.
17. Lesperance MM, Hall JW, Bess FH, et al. A gene for autosomal dominant nonsyndromic hereditary hearing impairment maps to 4p16.3. Hum Mol Genet 1995;4:1967-72.
18. International Organization for Standardisation. Acoustics-threshold of hearing by air conduction as a function of age and sex for otologically normal persons. ISO 7029. Geneva: International Organization for Standardization, 1984.
19. Lathrop GM, Lalouel JM. Easy calculations of lod scores and genetic risks on small computers. Am J Hum Genet 1984;36:460-5.
20. Dib C, Fauré S, Fizames C, et al. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 1996;380:152-4.
21. Goldstein DB, Ruiz Linares A, Cavalli-Sforza LL, et al. Genetic absolute dating based on microsatellites and the origin of modern humans. Proc Natl Acad Sci USA 1995;92:6723-7.
22. Allitto BA, MacDonald ME, Bucan M, et al. Increased recombination adjacent to the Huntington disease-linked D4S10 marker. Genomics 1991;9:104-12,
23. Mochizuki T, Lemmink HH, Mariyama M, et al. Identification of mutations in the α3(IV) and α4(IV) collagen genes in autosomal recessive Alport syndrome. Nat Genet 1994;8:77-81.
24. De Kok YJM, Vossenaar ER, Cremers CWRJ, et al. Identification of a hot spot for microdeletions in patients with X-linked deafness type 3 (DFN3) 900 kb proximal to the DFN3 gene POU3F4. Hum Mol Genet 1996;9:1229-35.