Treatment of hyperinsulinaemic hypoglycaemia with nifedipine

European Journal of Pediatrics

Volumn 158, Issue 3, 1999, Pages 204-206

  Santer, R ^a   Eichmann, D ^a   Hufnagel, M ^a   Quick, P ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Hyperinsulinism; Hypoglycemia; Nesidioblastosis; Nifedipine; Persistent hyperinsulinaemic hypoglycaemia of infancy

Indexed keywords

DIAZOXIDE; NIFEDIPINE;

ARTICLE; CASE REPORT; DOSE RESPONSE; FEMALE; GLUCOSE METABOLISM; HUMAN; HYPERINSULINEMIA; HYPERTRICHOSIS; HYPOGLYCEMIA; INSULINOMA; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

BLOOD GLUCOSE; CALCIUM CHANNEL BLOCKERS; FEMALE; HUMANS; HYPERINSULINISM; HYPOGLYCEMIA; INFANT; NIFEDIPINE;

EID: 0033003635     PISSN: 03406199     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004310051049     Document Type: Article

References (10)

1. 1. Bruining GJ (1992) Recent advances in hyperinsulinism and the pathogenesis of diabetes mellitus. Curr Opin Pediat 2:758-765
2. 2. Glaser B, Kesavan P, Heyman M, Davis E, Cuesta A, Buchs A, Stanley CA, Thornton PS, Permutt MA, Matschinsky FM, Herold KC (1998) Familial hyperinsulinism caused by an activating glucokinase mutation. N Engl J Med 338:226-230
3. 3. Hufnagel M, Eichmann D, Stieh J, Santer R (1998) Further evidence for a dominant form of familial persistent hyperinsulinemic hypoglycemia of infancy: a family with documented hyperinsulinemia in two generations. J Clin Endocrinol Metab 83:2215-2216
4. 4. Kane C, Lindley KJ, Johnson PRV, James RFL, Milla PJ, Aynsley-Green A, Dunne MJ (1997) Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin. J Clin Invest 100:1888-1893
5. 5. Lindley KJ, Dunne MJ, Kane C, Shepherd RM, Squires PE, James RFL, Johnson PRV, Eckhardt S, Wakeling E, Dattani M, Milla PJ, Aynsley-Green A (1996) Ionic control of β-cell function in nesidioblastosis: A possible therapeutic role for calcium channel blockade. Arch Dis Child 74:373-378
6. 6. Milner RD (1996) Nesidioblastosis unravelled. Arch Dis Child 74:369-372
7. 7. Newgard CB, McGarry JD (1995) Metabolic coupling factors in pancreatic beta-cell signal transduction. Annu Rev Biochem 64:689-719
8. 8. Stanley CA, Lieu YK, Hsu BYL, Burlina AB, Greenberg CR, Hopwood NJ, Perlman K, Rich BH, Zammarchi E, Poncz M (1998) Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 338:1352-1357
9. 9. Thomas P, Cote, GJ, Wohllk N, Haddad B, Mathew PM, Rabl W, Aguilar-Bryan L, Gagel RF Bryan J (1995) Mutations in the sulfonylurea receptor gene in familial persistent hyperinsulinemic hypoglycemia of infancy. Science 268:426-429
10. 10. Thomas P, Ye Y, Lightner E (1996) Mutation of the pancreatic islet inward rectifier Kir6.2 also leads to familial persistent hyperinsulinemic hypoglycemia of infancy. Hum Molec Genet 5:1809-1812