Two mechanisms of antimutagenicity of the aminothiols cysteamine and WR- 1065 in Saccharomyces cerevisiae

Toxicology in Vitro

Volumn 13, Issue 1, 1999, Pages 1-9

  Hoffmann, G R ^a   Shorter, R A ^a   Quaranta, J L ^a   McMaster, P D ^a  

^a Center for Interdisciplinary Studies   (United States)

Author keywords

propiolactone; Antimutagen; Bleomycin; Cysteamine; Desmutagen; WR 1065; Yeast

Indexed keywords

2 (3 AMINOPROPYLAMINO)ETHANETHIOL; ANTIMUTAGENIC AGENT; BLEOMYCIN; PROPIOLACTONE;

ARTICLE; GENE INDUCTION; GENOTOXICITY; IONIZING RADIATION; MUTAGEN TESTING; MUTATION; NONHUMAN; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0033003605     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(98)00060-5     Document Type: Article

References (46)

1. TMMouse: preliminary data on stomach, liver and bone marrow. Mutation Research. 360:1996;83-87.
2. Brusick D. J. The genetic properties of beta-propiolactone. Mutation Research. 39:1977;241-256.
3. Cederberg H., Ramel C. Modifications of the effect of bleomycin in the somatic mutation and recombination test in Drosophila melanogaster. Mutation Research. 214:1989;69-80.
4. Chatterjee A., Jacob-Raman M., Mohapatra B. Potentiation of bleomycin-induced chromosome aberrations by the radioprotector reduced glutathione. Mutation Research. 214:1989;207-213.
5. Cliet I., Melcion C., Cordier A. Lack of predictivity of bone marrow micronucleus test versus testis micronucleus test: comparison with four carcinogens. Mutation Research. 292:1993;105-111.
6. De Flora S., Rosenkranz H. S., Klopman G. Structural basis of antimutagenicity of chemicals towards 4-nitroquinoline 1-oxide in Salmonella typhimurium. Mutagenesis. 9:1994;39-45.
7. DeMarini D. M. (1991) Environmental mutagens/complex mixtures. In Genetic Toxicology. Edited by A. P. Li and R. H. Heflich, pp. 285-302. CRC Press, Boca Raton, FL.
8. Demopoulos N. A., Kappas A., Pelecanos M. Recombinogenic and mutagenic effects of the antitumour antibiotic bleomycin in Aspergillus nidulans. Mutation Research. 102:1982;51-57.
9. Ferguson L. R. Antimutagens as cancer chemopreventive agents in the diet. Mutation Research. 307:1994;395-410.
10. Ferguson L. R., Turner P. M. Mitotic crossing-over by anticancer drugs in Saccharomyces cerevisiae strain D5. Mutation Research. 204:1988;239-249.
11. Feuerstein B. G., Pattabiraman N. and Marton L. J. (1986) Spermine-DNA interactions: A theoretical study. Proceedings of the National Academy of Sciences of the U.S.A. 83, 5948-5952.
12. Glover D., Fox K. R., Weiler C., Kligerman M. M., Turrisi A., Glick J. H. Clinical trials of WR-2721 prior to alkylating agent chemotherapy and radiotherapy. Pharmacology and Therapeutics. 39:1988;3-7.
13. Gundelach E. Suppressor studies on ilv1 mutants of Saccharomyces cerevisiae. Mutation Research. 20:1973;25-33.
14. Hall E. J. (1988) Radiobiology for the Radiologist, 3rd edn. J. B. Lippincott Co, Philadelphia.
15. Hannan M. A., Nasim A. Genetic activity of bleomycin: Differential effects on mitotic recombination and mutations in yeast. Mutation Research. 53:1978;309-316.
16. Hartman P. E., Shankel D. M. Antimutagens and anticarcinogens: A survey of putative interceptor molecules. Environmental and Molecular Mutagenesis. 15:1990;145-182.
17. Hay J., Shahzeidi S., Laurent G. Mechanisms of bleomycin-induced lung damage. Archives of Toxicology. 65:1991;81-94.
18. Hoffmann G. R. Induction of Genetic Recombination: Consequences and model systems. Environmental and Molecular Mutagenesis. 23:(Suppl. 24):1994;59-66.
19. Hoffmann G. R. (1996) Genetic toxicology. In Casarett and Doull's Toxicology: The Basic Science of Poisons. Edited by C. D. Klaassen, 5th edn, pp. 269-300. McGraw Hill, New York.
20. 0 human lymphocytes. Toxicology Letters. 78:1995;147-151.
21. Hoffmann G. R., Quaranta J. L., Shorter R. A., Littlefield L. G. Modulation of bleomycin-induced mitotic recombination in yeast by the aminothiols cysteamine and WR-1065. Molecular and General Genetics. 249:1995;366-374.
22. 0 human lymphocytes. Mutation Research. 307:1994;273-283.
23. Kada T., Inoue T., Ohta T. and Shirasu Y. (1986) Antimutagens and their modes of action. In Antimutagenesis and Anticarcinogenesis Mechanisms. Edited by D. M. Shankel, P. E. Hartman, T. Kada and A. Hollaender, pp. 181-196. Plenum Press, New York.
24. Kane S. A., Hecht S. M. Polynucleotide recognition and degradation by bleomycin. Progress in Nucleic Acid Research and Molecular Biology. 49:1994;313-352.
25. Littlefield L. G., Joiner E. E., Colyer S. P., Sallam F., Frome E. L. Concentration-dependent protection against X-ray-induced chromosome aberrations in human lymphocytes by the aminothiol WR-1065. Radiation Research. 133:1993;88-93.
26. Liquier J., Fort L., Nguyen Dai D., Cao A., Taillandier E. DNA protection by aminothiols: study of the cysteamine-DNA interaction by vibrational spectroscopy. International Journal of Biological Macromolecules. 5:1983;89-93.
27. McCann J., Choi E., Yamasaki E. and Ames B. N. (1975) Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proceedings of the National Academy of Sciences of the U.S.A. 72, 5135-5139.
28. Mc.Koy J. F., Pleninger P., Wall L., Pramanik A., Martinez M., Moore C. W. Genetic changes and bioassays in bleomycin- and phleomycin-treated cells, and their relationship to chromosomal breaks. Mutation Research. 336:1995;19-27.
29. Moore C. W. Bleomycin-induced mutation and recombination in Saccharomyces cerevisiae. Mutation Research. 58:1978;41-49.
30. Nagy B., Grdina D. J. Protective effects of 2-[(aminopropyl)amino] ethanethiol against bleomycin and nitrogen mustard-induced mutagenicity in V79 cells. International Journal of Radiation Oncology, Biology, Physics. 12:1986;1475-1478.
31. Povirk L. F. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes. Mutation Research. 355:1996;71-89.
32. Povirk L. F., Austin M. J. F. Genotoxicity of bleomycin. Mutation Research. 257:1991;127-143.
33. Purdie J. W. A comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. Radiation Research. 77:1979;303-311.
34. Purdie J. W., Inhaber E. R., Schneider H., Labelle J. L. Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection. International Journal of Radiation Biology. 43:1983;517-527.
35. Ramel C., Alekperov U. K., Ames B. N., Kada T., Wattenberg L. W. Inhibitors of mutagenesis and their relevance to carcinogenesis. Mutation Research. 168:1986;47-65.
36. 60Co γ-ray and fission-spectrum neutron-induced chromosome damage in V79 cells. Radiation Research. 113:1988;145-154.
37. Sengstag C. The role of mitotic recombination in carcinogenesis. Critical Reviews in Toxicology. 24:1994;323-353.
38. Shigematsu N., Schwartz J. L., Grdina D. J. Protection against radiation-induced mutagenesis at the hprt locus by spermine and N,N″-(dithiodi-2,1-ethanediyl)bis-1,3-propanediamine (WR-33278). Mutagenesis. 9:1994;355-360.
39. Smoluk G. D., Fahey R. C., Calabro-Jones P. M., Aguilera J. A., Ward J. F. Radioprotection of cells in culture by WR-2721 and derivatives: Form of the drug responsible for protection. Cancer Research. 48:1988;3641-3647.
40. Smoluk G. D., Fahey R. C., Ward J. F. Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiation Research. 107:1986;194-204.
41. Strekowski L., Harden D. B., Wydra R. L., Stewart K. D., Wilson W. D. Molecular basis for the potentiation of bleomycin-mediated degradation of DNA by polyamines. Experimental and molecular mechanical studies. Journal of Molecular Recognition. 2:1989;158-166.
42. Waters M. D., Brady A. L., Stack H. F., Brockman H. E. Antimutagenicity profiles for some model compounds. Mutation Research. 238:1990;57-85.
43. Wattenberg L. W., Hochalter J. B., Galbraith A. R. Inhibition of β-propiolactone-induced mutagenesis and neoplasia by sodium thiosulfate. Cancer Research. 47:1987;4351-4354.
44. Zimmermann F. K. Procedures used in the induction of mitotic recombination and mutation in the yeast Saccharomyces cerevisiae. Mutation Research. 31:1975;71-86.
45. Zimmermann F. K., Kern R., Rasenberger H. A yeast strain for the simultaneous detection of induced mitotic crossing over, mitotic gene conversion and reverse mutation. Mutation Research. 28:1975;381-388.
46. Zimmermann F. K., von Borstel R. C., von Halle E. S., Parry J. M., Siebert D., Zetterberg G., Barale R., Loprieno N. Testing of chemicals for genetic activity with Saccharomyces cerevisiae: a report of the U.S. Environmental Protection Agency Gene-Tox Program. Mutation Research. 133:1984;199-244.