Development of plasma kallikrein selective inhibitors

Biopolymers - Peptide Science Section

Volumn 51, Issue 1, 1999, Pages 41-50

  Okada, Yoshio ^a   Tsuda, Yuko ^a   Tada, Mayako ^b   Wanaka, Keiko ^b   Hijikata Okunomiya, Akiko ^c   Okamoto, Utako ^b   Okamoto, Shosuke ^b  

^a KOBE GAKUIN UNIVERSITY   (Japan)

^b Kobe Res Projects Thromb H   (Japan)

^c KOBE UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

N (trans 4 aminomethylcyclohexanecarbonyl)phenylalanine 4 carboxymethylanilide (Tra Phe APAA); New affinity gel; PKSI Toyopearl; Plasma kallikrein selective inhibitors

Indexed keywords

ADSORPTION; BIOSYNTHESIS; CATALYST ACTIVITY; CATALYST SELECTIVITY; MOLECULAR STRUCTURE;

PLASMA KALLIKREIN INHIBITORS;

ENZYME INHIBITION;

BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 12A; KALLIKREIN INHIBITOR; N (4 AMINO METHYLCYCLOHEXANECARBONYL)PHENYLALANINE 4 CARBOXYMETHYLANILIDE; PLASMIN; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG; UROKINASE;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG DESIGN; HUMANS; KALLIKREINS; KINETICS; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PHENYLALANINE; PLASMIN; SERINE PROTEINASE INHIBITORS; THROMBIN; TRANEXAMIC ACID; URINARY PLASMINOGEN ACTIVATOR;

EID: 0033003597     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0282(1999)51:1<41::AID-BIP5>3.0.CO;2-Y     Document Type: Article

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