Genes involved in animal models of obesity and anorexia

Journal of Internal Medicine

Volumn 245, Issue 6, 1999, Pages 613-619

  Schalling, Martin ^a   Johansen, J ^a   Nordfors, L ^a   Lonnqvist F ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Anorexia; Genetics; Leptin; Mouse model; Obesity; Quantitative trait loci

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; BODY MASS; BODY WEIGHT; CHROMOSOMAL LOCALIZATION; CONFERENCE PAPER; GENE CONTROL; GENE ISOLATION; GENE LOCUS; INDUSTRIALIZATION; MOLECULAR GENETICS; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT;

ADIPOSE TISSUE; ANIMALS; ANOREXIA; DISEASE MODELS, ANIMAL; HUMANS; INSULIN RESISTANCE; LEPTIN; MICE; MICE, INBRED STRAINS; MUTATION; OBESITY; PROTEINS; RATS;

EID: 0033003536     PISSN: 09546820     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2796.1999.00489.x     Document Type: Conference Paper

References (49)

1. 1 Bultman SJ, Michaud EJ, Woychik RP. Molecular characterization of the mouse agouti locus. Cell 1992; 71: 1195-204.
2. 2 Miller MW, Duhl DMJ, Vrieling H, Cordes SP, Ollman MM, Winkes BM et al. Cloning of the mouse agouti gene predicts a secreted protein ubiquitously expressed in mice carrying the lethal yellow mutation. Genes Dev 1993; 7: 454-67.
3. y) mutation. Proc Natl Acad Sci USA 1994; 91: 2562-6.
4. 4 Perry WL, Hustad CM, Swing DA, Jenkin NA, Copeland NG. A transgenic mouse assay for agouti protein activity. Genetics 1995; 140: 267-74.
5. 5 Kleibig ML, Wilkinson JG, Geisler JG, Woychik RP. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes and yellow fur. Proc Natl Acad Sci USA 1995; 92: 4728-12.
6. 6 Zemel MB, Han Kim J, Woychik RP, Michaud EJ, Kadwell SH, Patel IR et al. Agouti regulation of intracellular calcium: role in the insulin resistance of viable yellow mice. Proc Natl Acad Sci USA 1995; 92: 4733-7.
7. 7 Jones BH, Kim JH, Zemel MB. Upregulation of adipocyte metabolism by agouti protein: possible paracrine actions in yellow mouse obesity. Am J Physiol 1996; 270: E192-6.
8. 8 Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature 1997; 385: 165-8.
9. 9 Lu D, Willard D, Patel IR, Kadwell S, Overton L, Kost T et al. Agouti protein is an antagonist of the melanocyte-stimulating hormone receptor. Nature 1994; 371: 799-802.
10. 10 Ingalls AM, Dickie MM, Snell GD. Obese, new mutation in house mouse. J Hered 1950; 41: 317-8.
11. 11 Zhang Y, Proenca R, Maffei M, Barone M, Lori L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-32.
12. 12 Maffei M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y et al. Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc Natl Acad Sci USA 1995; 92: 6957-60.
13. 13 Stephens TW, Basinski M, Bristow M, Buc-Valleskey JM, Burgett SG, Craft L et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 550-34.
14. 14 Vaisse C, Halaas JL. Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM. Leptin activation of Stat 3 in the hypothalamus of wild type and ob/ob mice but not db/db mice. Nature Genet 1996; 3(14): 95-7.
15. 15 Ahima RS, Prabakaran D, Mantzoros C, Daqing Q, Lowell B, Maratos Flier E et al. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-52.
16. 16 Green ED, Maffei M, Braden VV, Proenca R, DeSilva U, Zhang Y et al. The human obese (ob) gene: expression pattern and mapping on the physical, cytogenic, and genetic maps of chromosome 7, Genome Res 1995; 5: 5-12.
17. 2 receptor (DRD2) gene. Molecular Psychiatry 1996; 1: 325-35.
18. 18 Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-9.
19. 19 Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T et al. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-43.
20. 20 Haalas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT. Rabonowitz D et al. Weight-reduction effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-6.
21. 21 Chehab F, Lim ME, Ronghua LU. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 118-20.
22. 22 Montague CT, Farooqi IS, Whitehead JP, Soos MA, Kau H, Wareham NJ et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 901-7.
23. 23 Coleman DL. Obese and diabetes: two mutant genes causing diabetes obesity syndromes in mice. Diabetologia 1978; 14: 141-8.
24. 24 Tartaglia L, Dembski L, Weng X, Deng N, Culpepper J, Devos R et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 1995; 83: 1263-71.
25. 25 Chen H, Charlat O, Tartaglia LA. Woolf EA, Weng X, Ellis SJ et al. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/ db mice. Cell 1996; 84: 491-5.
26. 26 Lee G-H, Proenca R, Montez JM, Caroll KM, Darvishzadeh JG, Lee JI et al. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-5.
27. 27 Ghilardi N, Ziegler S, Wiestner A. Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93: 6231-5.
28. 28 Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H et al. The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 1996; 93: 8174-8.
29. 29 Naggert JK, Fricker LD, Vartamov O, Nishina PM, Rouille Y, Steiner DF et al. Hyperproinsulinemia in obese fat/fat mice associated with a carboxypeptidate E mutatin which reduces enzyme activity. Nature Genet 1995; 10: 135-42.
30. 30 Jackson RS, Creemers JWM, Ohagi S, Raffin-Sanson M-L, Sanders L, Montague CT et al. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase I gene. Nat Genet 1997; 16: 303-6.
31. 31 Noben-Trauth K, Naggert JK, North MA, Nishina PM. A candidate gene for the mouse mutation Tubby Nature 1996; 380: 534-8.
32. 32 Kleyn PW, Fan W, Kovats SG, Lee JJ, Pulido JC. Wu Y et al. Identification and characterization of the mouse obesity gene tubby: a member of a novel gene family. Cell 1996; 85: 281-90.
33. 33 Wallace ME, MacSwiney FM. An inherited mild middle-aged adiposity in wild mice. J Hyg 1979; 82: 109-17.
34. 34 Trayhurn P, James WPT, Gurr MI. Studies on the body composition, fat distribution and fat cell size and number of Ad, a new obese mutant mouse. Br J Nutr 1979; 41: 211-21.
35. 35 Maltais LJ, Lane PW, Beamer WG. Anorexia, a recessive mutation causing starvation in preweanling mice. J Hered 1984; 75: 468-72.
36. 36 Son JH, Baker H, Park DH, Job TH. Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevekipmental mouse mutant. Anorexia (anx). Mol Brain Res 1994; 25: 129-34.
37. 37 Broberger C, Johansen J, Schalling M, Hökfelt T. Hypothalamic neurohistochemistry of the murine anorexia (anx/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus. J Comp Neurol 1997; 387: 224-35.
38. 38 Clark JT, Kalra PS, Crowley WK, Kalra SP. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 1984; 115: 427-9.
39. 59 Stanley BG, Leibowitz SF. Neuropeptide Y injected in the paraventricular hypothalamus: a powerful stimulant of reeding behavior. Proc Natl Acad Sci USA 1985; 82: 3940-43.
40. 40 Erickson JC, Clegg KE, Palmiter RD. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 1996; 381: 415-8.
41. 41 Zhou X, Benson KF, Ashar HR, Chada K. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 1995; 376: 771-4.
42. 42 Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S et al. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motif fused in lipomas to distinct transscriptional regulatory domains. Cell 1995: 82: 57-65.
43. 43 Schoenmakers EFPM, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven WJW. Recurrent rearrangements in the high mobility group proten gene, HMGI-C, in benign mesenchymal tumours. Nature Genet 1995; 10: 436-43.
44. 44 West DB, Goudey-Lefevre J, York B, Truett GE. Dietary obesity linked to genetic loci on chromosomes 9 and 15 in a polygenic mouse model. J Clin Invest 1994; 94: 1410-16.
45. 45 West DB, Waguespack J, York B, Goudey-Lefevre J, Price RA. Genetics of dietary obesity in AKR/J x SWR/J mice: segregation of the trait and identification of a linked locus on chromosome 4. Mammalian Genome 1994; 5: 546-52.
46. 46 Gauguier D, Froguel P, Parent V, Bernard C. Bihoreau M-T, Portha B et al. Chromosomal mapping of genetic loci associated with non-insulin dependent diabetes in the GK rat. Nat Genet 1996; 12: 38-43.
47. 47 Galli J, Li L-S, Glaser A, Östenson C-G. Jiao H, Fakbrai-Rad H et al. Genetic analysis of non-insulin dependent diabetes mellitus in the GK rat. Nat Genet 1996; 12: 31-7.
48. 48 Chagnon YC, Bouchard C. Genetics of obesity, advances from rodent studies. TIG 1996; 12: 441-4.
49. 49 Guerre-Millo M, Staels B, Auwerx J. New insights into obesity genes. Diabetologia 1996; 39: 1528-31.