In vitro sequestration of two organophosphorus homologs by the rat liver

Chemico-Biological Interactions

Volumn 119-120, Issue , 1999, Pages 277-282

  Santhoshkumar, Puttur ^a   Shivanandappa, Thimmappa ^a  

^a CENTRAL FOOD TECHNOLOGICAL RESEARCH INSTITUTE   (India)

Author keywords

In vitro; Liver; Organophosphates; Sequestration

Indexed keywords

ACETYLCHOLINESTERASE; BROMOPHOS; BROMOPHOS ETHYL; BROMOXON; CARBOXYLESTERASE; CHLORPYRIFOS; ETHYLBROMOXON; MIPAFOX; ORGANOPHOSPHATE INSECTICIDE; ORGANOPHOSPHORUS COMPOUND; PARAOXON; PARATHION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; BINDING SITE; CONFERENCE PAPER; DETOXIFICATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; LIVER; LIVER TOXICITY; NONHUMAN; RAT;

ACETYLCHOLINESTERASE; ANIMALS; BRAIN; CARBOXYLESTERASE; CARBOXYLIC ESTER HYDROLASES; CHOLINESTERASE INHIBITORS; FEMALE; INSECTICIDES; KINETICS; LIVER; METABOLIC DETOXICATION, DRUG; PHOSPHORIC ACID ESTERS; RATS; THIOPHOSPHORIC ACID ESTERS;

RATTUS NORVEGICUS;

EID: 0033003288     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(99)00037-X     Document Type: Conference Paper

References (20)

1. Mentlein R., Schumann M., Heymann E. Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterase) from rat liver microsomes. Arch. Biochem. Biophy. 234:1984;612-621.
2. Satoh T., Hosokawa M. Molecular aspects of carboxylesterase isoforms in comparison with other esterases. Toxicol. Lett. 82/83:1995;439-445.
3. Maxwell D.M. Detoxication of organophosphorus compounds by carboxylesterases. Chambers J.E., Levi P.E. Organophosphorus Chemistry, Fate and Effects. 1992;183-199 Academic Press, New York.
4. Sterri S., Fonnum F. Detoxication of organophosphorus compounds. Brzin M., Barnard E.A., Sket D. Cholinesterases: Fundamental and Applied Aspects. 1984;110-129 deGruyter, Berlin.
5. Maxwell D.M., Vlahacos C.P., Lenz D.E. A pharmaco-dynamic model for soman in rat. Toxicol. Lett. 43:1988;175-188.
6. Maxwell D.M. The specificity of carboxylesterase protection against the toxicity of organophosphorus compounds. Toxicol. Appl. Pharmacol. 114:1992;306-312.
7. Chambers H., Brown B., Chambers J.E. Noncatalytic detoxication of six organophosphorus compounds by rat liver homogenates. Pestic. Biochem. Physiol. 36:1990;308-315.
8. Santhoshkumar P., Karanth S., Shivanandappa T. Neurotoxicity and pattern of acetylcholinesterase inhibition in the brain regions of rat by bromophos and ethylbromophos. Fundam. Appl. Toxicol. 32:1996;23-30.
9. Ellman G.L., Courtney K.D., Andres V., Featherstone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:1961;88-95.
10. Nousiainen U., Torronen R. Differentiation of microsomal and cytosolic carboxylesterases in rat liver by in vivo and in vitro inhibition. Gen. Pharmacol. 15:1984;223-227.
11. Sultatos L.G., Costa L.G., Murphy S.D. Factors involved in the differential acute toxicity of the insecticides chlorpyrifos and methyl chlorpyrifos in mice. Toxicol. Appl. Pharmacol. 65:1982;144-152.
12. Clement J.G. Role of aliesterases in organophosphate poisoning. Fundam. Appl. Toxicol. 4:1984;S96-S105.
13. Jokanovic M., Kosanovic M., Maksimovic M. Interaction of organophosphorus compounds with carboxylesterases in the rat. Arch. Toxicol. 70:1996;444-450.
14. Jokanovic M., Maksimovic M., Boskovic B., Knezevic D. Detoxication of highly toxic organophosphorus compounds in different animal species. Arch. Toxicol. Kinet. Xenobiot. Metab. 2:1994;41-51.
15. Boskovic B. The influence of 2-O-cresyl-4H-1:3:2 benzodioxa-phosphorine-2-oxide (CBDP) on organophosphate poisoning and its therapy. Arch. Toxicol. 42:1979;207-216.
16. Fonnum F., Sterri S.H., Aas P., Johnsen H. Carboxylesterases, importance for detoxification of organophosphorus anticholinesterases and trichothecenes. Fundam. Appl. Toxicol. 5:1985;S29-S38.
17. Chanda S.M., Mortensen S.R., Moser V.C., Padilla S. Tissue-specific effects of chlorpyrifos on carboxylesterase and cholinesterase activity in adult rats: an in vitro and in vivo comparison. Fundam. Appl. Toxicol. 38:1997;148-157.
18. Karanth S., Shivanandappa T. Organophosphate-sensitive carboxylesterase isozyme(s) in the rat liver. Quinn D.M., Balasubramanian A.S., Doctor B.P., Taylor P. Enzymes of the Cholinesterase Family. 1995;394 Plenum, P, New York.
19. Novak R., Padilla S. An in vitro comparison of rat and chicken brain neurotoxic esterase. Fundam. Appl. Toxicol. 6:1986;464-471.
20. Heymann E., Hoppe W., Krusselmann A., Tschoetschel C. Organophosphate sensitive and insensitive carboxylesterases in human skin. Chem.-Biol. Interact. 87:1993;217-226.