The effects of intraperitoneal piroxicam and low molecular weight heparin in prevention of adhesion reformation in rat uterine horn

Research in Experimental Medicine

Volumn 198, Issue 6, 1999, Pages 269-275

  Tayyar, Mehmet ^a,b   Başbuǧ, Mustafa ^a  

^a ERCIYES UNIVERSITY   (Turkey)

^b NONE   (Turkey)

Author keywords

Adhesion prevention; Adhesion reformation; Low molecular weight heparin; Piroxicam

Indexed keywords

ANTICOAGULANT AGENT; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAUTERIZATION; CONTROLLED STUDY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; LAPAROTOMY; NONHUMAN; PERITONEUM ADHESION; PRIORITY JOURNAL; RAT; SECOND LOOK SURGERY; TIME;

EID: 0033002942     PISSN: 03009130     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004330050110     Document Type: Article

References (25)

1. Al-Chalabi HA, Otubo JA (1987) Value of a single intraperitoneal dose of heparin in prevention of adhesion formation: an experimental evaluation in rats. Int J Fertil 32: 332-335
2. Baram D, Rashkovsky M, Herskoviz R, Drucker I, Reshef T, Ben-Shitrit S, Mekori YA (1997) Inhibitory effects of low molecular weight heparin on mediator release by mast cells: preferential inhibition of cytokine production and mast cell-dependent cutaneous inflammation. Clin Exp Immunol 110: 485-491
3. Başbuǧ M, Aygen E, Tayyar M, Kaya E, Narin F, Öktem Ö (1998) Hyaluronic acid plus heparin for improved efficacy prevention of adhesion formation in rat uterine horn model. Eur J Obstet Gynecol Reprod Biol 78: 109-112
4. Boneu B, Caranobe C, Cadroy Y (1988) Pharmacokinetic studies of standard unfractioned heparin, and low molecular weight heparins in the rabbit. Semin Tromb Hemost 14: 18-27
5. Cofer KF, Himebaugh KS, Gauvin JM, Hurd WW (1994) Inhibition of adhesion reformation in the rabbit model by meclofenamate: an inhibitor of both prostaglandin and leukotriene production. Fertil Steril 62: 1262-1265
6. Dahners LE, Gilbert JA, Lester GA, Taft TN, Payne LZ (1988) The effect of a nonsteroidal antiinflammatory drug on the healing of ligaments. Am J Sports Med 16: 641-646
7. Diamond MP (1988) Surgical aspects of infertility. In: Sciarra JW (ed) Gynecology and obstetrics. JB Lippincott, Philadelphia, pp 1-19
8. DiZerega GS (1994) Contemporary adhesion prevention. Fertil Steril 61: 219-235
9. Dunn DL, Barke RA, Ahrenholz DH, Humprey EW, Simmons RC (1984) The adjuvant effect of peritoneal fluid in experimental peritonitis. Ann Surg 199: 37-43
10. Friedman MD, Leese P, Prasad P, Hayden D (1990) An evaluation of the biologic response to fraxiparine (a low molecular weight heparin) in the healthy individual. J Clin Pharmacol 30: 720-727
11. Fukasawa M, Girgis W, diZerega GS (1991) Inhibition of postsurgical adhesions in a standardized rabbit model II. Intraperitoneal treatment with heparin. Int J Fertil 36: 296-301
12. Garcia-Vicuna R, Diaz-Gonzales F, Gonzales-Alvaro I, Del Pozo MA, Mollinedo F, Cabanas C, Gonzales-Amaro R, Sanchez-Madrid F (1997) Prevention of cytokine-induced changes in leukocyte adhesion receptors by nonsteroidal antiinflammatory drugs from the oxicam family. Arthritis Rheum 40: 143-153
13. Gomel V, Urman B, Gürgan T (1996) Pathophysiology of adhesion formation and strategies for prevention. J Reprod Med 41: 35-41
14. Guerre EF, Diamond MP (1993) Adhesion prevention, does anything work? Infertil Reprod Med Clin North Am 4: 275-287
15. Harris ES, Morgan RF, Rodeheaver GT (1995) Analysis of the kinetics of peritoneal adhesion formation in the rat and evaluation of potential antiadhesive agents. Surgery 117: 663-669
16. Linsky CB, Diamond MP, Cunningham T, Constantine B, DeCherney AH, diZerega GS (1987) Adhesion reduction in a rabbit uterine horn model using an absorbable barrier TC-7. J Reprod Med 32: 17-20
17. Markwardt F, Klocking HP (1977) Heparin induced release of plasminogen activator. Haemostasis 6: 370-374
18. Orita H, Campeau JD, Gale JA, Nakamura RM, diZerega GS (1986) Differential secretion of plasminogen activator activity by postsurgical activated macrophages. J Surg Res 41: 569-573
19. Rodgers KE (1990) Nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of postsurgical adhesions. Prog Clin Biol Res 358: 119-129
20. Rodgers KE, Girgis W, Johns D, diZerega GS (1990) Intraperitoneal tolmetin prevents postsurgical adhesion formation in rabbits. Int J Fertil 35: 40-45
21. Rodgers KE, Ellefson D, Girgis W, diZerega GS (1992) Protease and protease inhibitor secretion by post-surgical macrophages following in vitro exposure to tolmetin. Agents Actions 6: 248-257
22. Roskos LK, Boudinot FD (1990) Effects of dose and sex on the pharmacokinetics of piroxicam in the rat. Biopharm Drug Dispos 11: 215-225
23. Türkçapar AG, Özarslan C, Erdem E, Bumin C, Erverdi N, Kutlay J (1995) The effectiveness of low molecular weight heparin on adhesion formation in experimental rat model. Int Surg 80: 92-94
24. Urman B, Gomel V (1991) Effect of hyaluronic acid on postoperative intraperitoneal adhesion formation and reformation in the rat model. Fertil Steril 56: 568-570
25. Yilmazlar T, Kaya E, Gürpinar E, Emiroǧlu H (1996) Efficacy of tenoxicam on intra-abdominal adhesion prevention in a rat model. J Int Med Res 24: 352-357