Screening procedure for detection of dihydropyridine calcium channel blocker metabolites in urine as part of a systematic toxicological analysis procedure for acidic compounds by gas chromatography-mass spectrometry after extractive methylation

Journal of Analytical Toxicology

Volumn 23, Issue 2, 1999, Pages 73-80

  Maurer, Hans H ^a   Arlt, Joachim W ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMLODIPINE; CALCIUM CHANNEL BLOCKING AGENT; DIHYDROPYRIDINE DERIVATIVE; DRUG METABOLITE; FELODIPINE; ISRADIPINE; NIFEDIPINE; NILVADIPINE; NIMODIPINE; NISOLDIPINE; NITRENDIPINE;

ANGINA PECTORIS; ANIMAL EXPERIMENT; ARTICLE; DRUG INTOXICATION; DRUG SCREENING; DRUG URINE LEVEL; GAS CHROMATOGRAPHY; HEART ARRHYTHMIA; HUMAN; HYPERTENSION; MASS SPECTROMETRY; METHYLATION; NONHUMAN; RAT; SOLID PHASE EXTRACTION;

EID: 0033002899     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/23.2.73     Document Type: Article

References (43)

1. C. Jean and R. Laplanche. Assay of isradipine and of its major metabolites in biological fluids by capillary gas chromatography and chemical ionization mass spectrometry. J. Chromatogr. 428: 61-69 (1988).
2. Y. Tokuma, T. Fujiwara, and H. Noguchi. Determination of nilvadipine in human plasma by capillary column gas chromatography-negative-ion chemical-ionization mass spectrometry. J. Chromatogr. 345: 51-58 (1985).
3. J.D. Dru, J.Y. Hsieh, B.K. Matuszewski, and M.R. Dobrinska. Determination of felodipine, its enantiomers, and a pyridine metabolite in human plasma by capillary gas chromatography with mass spectrometric detection. J. Chromatogr. 666: 259-267 (1995).
4. Y. Tokuma, T. Fujiwara, and H. Noguchi. Combined capillary column gas chromatography/electron capture negative ion chemical ionization mass spectrometry of dihydropyridine calcium antagonists. Biomed. Environ. Mass Spectrom. 13: 251-255 (1986).
5. M.T. Rosseel, M.C. Bogaert, and L. Huyghens. Determination of the calcium antagonist nimodipine in plasma by capillary gas chromatography and nitrogen detection. J. Chromatogr. 533: 224-228 (1990).
6. A.P. Beresford, P.V. Macrae, D.A. Stopher, and B.A. Wood. Analysis of amlodipine in human plasma by gas chromatography. J. Chromatogr. 420: 178-183 (1987).
7. J. Van Harten, M.T. Lodewijks, J.W. Guyt Scholten, P. Van Brummelen, and D.D. Breimer. Gas chromatographic determination of nisoldipine and one of its metabolites in plasma. J. Chromatogr. 423: 327-333 (1987).
8. P.A. Soons and D.D. Breimer. Gas chromatographic analysis of nitrendipine and its pyridine metabolite in human plasma. J. Chromatogr. 428: 362-368 (1988).
9. G.J. Krol, A.J. Noe, S.C. Yeh, and K.D. Raemsch. Gas and liquid chromatographic analyses of nimodipine calcium antagonist in blood plasma and cerebrospinal fluid. J. Chromatogr. 305: 105-118 (1984).
10. M. Josefsson, A.L. Zackrisson, and B. Norlander. Sensitive high-performance liquid chromatographic analysis of amlodipine in human plasma with amperometric detection and a single-step solid-phase sample preparation. J. Chromatogr. 672: 310-313 (1995).
11. K. Shimooka, Y. Sawada, and H. Tatematsu. Analysis of amlodipine in serum by a sensitive high-performance liquid chromatographic method with amperometric detection, J. Pharm. Biomed. Anal. 7: 1267-1272 (1989).
12. J. Boutagy, F. Rumble, and F. Dunagan. Determination of isradipine and the oxidative pyridine metabolite in human plasma by high-performance liquid chromatography. J. Chromatogr. 487: 483-488 (1989).
13. T. Uno, T. Ohkubo, and K. Sugawara. Enantios-elective high-performance liquid chromatographic determination of nicardipine in human plasma. J. Chromatogr. 698: 181-186 (1997).
14. W.M. Muck. Enantiospecific determination of nimodipine in human plasma by liquid chromatography-tandem mass spectrometry. J. Chromatogr. A, 712: 45-53 (1995).
15. T. Yasuda, M. Tanaka, and K. Iba. Quantitative determination of amlodipine in serum by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. J. Mass. Spectrom. 31: 879-884 (1996).
16. H.H. Maurer. Identification of antiarrhythmic drugs and their metabolites in urine. Arch. Toxicol. 64: 218-230 (1990).
17. H.H. Maurer. Systematic toxicological analysis of drugs and their metabolites by gas chromatography-mass spectrometry. J. Chromatogr. 580: 3-41 (1992).
18. D. Scherling, W. Karl, C. Ahr, H.J. Ahr, and E. Wehinger. Pharmacokinetics of nisoldipine. III. Biotransformation of nisol dipine in rat, dog, monkey, and man. Drug Res. 38: 1105-1110 (1988).
19. J. Kann, C.J. Krol, K.D. Raemsch, D.E. Burkholder, and M.J. Levitt. Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers. J. Cardiovasc. Pharmacol. 6 Suppl 7: S968-S973 (1984).
20. A.P. Beresford, D. McGibney, M.J. Humphrey, P.V. Macrae, and D.A. Stopher. Metabolism and kinetics of amlodipine in man. Xenobiotica 18: 245-254 (1988).
21. C. Baarnhielm, A. Backman, K.J. Hoffmann, and L. Weidolf. Biotransformation of felodipine in liver microsomes from rat, dog, and man. Drug. Metab. Dispos. 14: 613-618 (1986).
22. K.D. Raemsch and J. Sommer. Pharmacokinetics and metabolism of nifedipine. Hypertension 5: 18-24 (1983).
23. D.R. Abernethy and J.B. Schwartz. Pharmacokinetics of calcium antagonists under development. Clin. Pharmacokinet. 15: 1-14 (1988).
24. A. Nieciecki, H.J. Huber, and F. Stanislaus. Pharmacokinetics of nilvadipine. J. Cardiovasc. Pharmacol. 20: 22-29 (1992).
25. J.W. Arlt and H.H. Maurer. On the toxicological detection of dihydropyridine calcium channel blockers and their metabolites in urine by GC-MS after extractive alkylation. In Proceedings of the Xth GTFCh Symposium, F. Pragst, Ed. Mosbach, Germany, 1997, pp 116-123.
26. J.W. Arlt. Systematische toxikologische Analyse (STA) zum Nachweis azider Arzneistoffe, Giftstoffe und irher Metaboliten im Urin nach extraktiver Methylierung mittels GC-MS. Doctoral thesis. University of Saarland, Homburg/Saarbrücken, Germany, 1998.
27. H.H. Maurer and J.W. Arlt. Detection of 4-hydroxycoumarin anti-coagulants and their metabolites in urine as part of a systematic toxicological analysis procedure for acidic drugs and poisons by gas chromatography-mass spectrometry (GC-MS) after extractive methylation. J. Chromatogr. B. 714: 181-195 (1998).
28. H.H. Maurer, T. Kraemer, and J.W. Arlt. Screening procedure for detection of ACE inhibitors, their metabolites and angiotensin II receptor antagonists in urine as part of a systematic toxicological analysis procedure for acidics by gas chromatography-mass spectrometry (GC-MS) after extractive methylation. Ther. Drug. Monit. 20: 706-713 (1998).
29. H.H. Maurer, J.W. Arlt, T. Kraemer, C.J. Schmitt, and A.A. Weber. Analytical development for low molecular weight xenobiotic com pounds. Arch. Toxicol. Suppl. 19: 189-197 (1997).
30. W.A. Joern. Confirmation of low concentrations of urinary benzo diazepines, including alprazolam and triazolam, by GC/MS: an extractive alkylation procedure. J. Anal. Toxicol. 16: 363-367 (1992).
31. A.M. Lisi, R. Kazlauskas, and C.J. Trout. Diuretic screening in human urine by gas chromatography-mass spectrometry: use of a macroreticular acrylic copolymer for the efficient removal of the coextracted phase-transfer reagent after derivatization by direct extractive alkylation. J. Chromatogr. 581: 57-63 (1992).
32. P. Hartvig, C. Fagerlund, and O. Gyllenhaal. Electron-capture gas chromatography of plasma sulphonylureas after extractive methylation. J. Chromatogr. 181: 17-24 (1980).
33. C. Fagerlund, P. Hartvig, and B. Lindstrom. Extractive alkylation of sulphonamide diuretics and their determination by electron-capture gas chromatography. J. Chromatogr. 168: 107-116 (1979).
34. A. Hulshoff and A.D. Forch. Alkylation with alkylhalides as a derivatization method for the gas chromatographic determination of acidic pharmaceuticals. J. Chromatogr. 220: 275-311 (1981).
35. L. Rivier, C. Grunauer and M. Saugy. Direct extractive methylation and automatic GC-MS screening and identification of drugs of abuse and other compounds of potential abuse in sport. In Proceedings of the 31st International TIAFT Meeting, R.K. Mueller, Ed. Leipzig, Germany, 1993, pp 419-422.
36. H.H. Maurer. Toxicological analysis of drugs and poisons by GC-MS. Spectrosc. Eur. 6: 21-23 (1994).
37. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral and GC Data of Drugs, Poisons, Pesticides, Pollutants and their Metabolites. Part 4. Wiley-VCH, Weinheim, Germany. In press.
38. K. Pfleger, H.H. Maurer, and A. Weber. Mass Spectral Library of Drugs, Pesticides, Poisons and their Metabolites. 3rd ed. Hewlett Packard, Palo Alto, CA. In press.
39. F.W. McLafferty and F. Turecek. Interpretation of Mass Spectra. University Science Books, Mill Valley, CA, 1993.
40. F. Barbato, L. Grumetto, and P. Morrica. Analysis of calcium channel blocking dihydropyridines and their degradation products by gas chromatography. Farmaco. 49: 461-466 (1994).
41. M. Ahnoff and B.A. Persson. Chromatography of calcium channel blockers. J. Chromatogr. 531: 181-213 (1990).
42. E. Kovats. Gaschromatographische Charakterisierung organischer Verbindungen. Teil 1. Retentionsindices aliphatischer Halogenide, Alkohole, Aldehyde und Ketone. Helv. Chim. Acta 41: 1915-1932 (1958).
43. R.A. de Zeeuw, J.P. Franke, H.H. Maurer, and K. Pfleger. Gas Chromatographic Retention Indices of Toxicologically Relevant Substances and their Metabolites (Report of the DFG commission for clinical toxicological analysis, special issue of the TIAFT bulletin). VCH Publishers, Weinheim, Germany, 1992.