The MexA-MexB-OprM multidrug efflux system of Pseudomonas aeruginosa is growth-phase regulated

FEMS Microbiology Letters

Volumn 173, Issue 1, 1999, Pages 35-39

  Evans, Kelly ^a   Poole, Keith ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Gene regulation; Multidrug efflux; Pseudomonas aeruginosa

Indexed keywords

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM CULTURE; CELL MEMBRANE PERMEABILITY; DRUG TRANSPORT; GENE EXPRESSION REGULATION; GROWTH CURVE; MULTIDRUG RESISTANCE; OPERON; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

BACTERIAL OUTER MEMBRANE PROTEINS; CARRIER PROTEINS; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE TRANSPORT PROTEINS; OPERON; PSEUDOMONAS AERUGINOSA;

EID: 0033002701     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1097(99)00053-1     Document Type: Article

References (19)

1. Nikaido, H. (1989) Outer membrane barrier as a mechanism of antimicrobial resistance. Antimicrob. Agents Chemother. 33, 1831-1836.
2. Li, X.Z., Livermore, D.M. and Nikaido, H. (1994) Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: resistance to tetracycline, chloramphenicol, and norfloxacin. Antimicrob. Agents Chemother. 38, 1732-1741.
3. Li, X.Z., Ma, D., Livermore, D.M. and Nikaido, H. (1994) Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance. Antimicrob. Agents Chemother. 38, 1742-1752.
4. Li, X.Z., Nikaido, H. and Poole, K. (1995) Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39, 1948-1953.
5. Gotoh, N., Tsujimoto, H., Poole, K., Yamagishi, J. and Nishino, T. (1995) The outer membrane protein OprM of Pseudomonas aeruginosa is encoded by oprK of the mexA-mexB-oprK multidrug resistance operon. Antimicrob. Agents Chemother. 39, 2567-2569.
6. Poole, K., Heinrichs, D.E. and Neshat, S. (1993) Cloning and sequence analysis of an EnvCD homologue in Pseudomonas aeruginosa: regulation by iron and possible involvement in the secretion of the siderophore pyoverdine. Mol. Microbiol. 10, 529-544.
7. Poole, K., Krebes, K., McNally, C. and Neshat, S. (1993) Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175, 7363-7372.
8. Masuda, N., Sakagawa, E. and Ohya, S. (1995) Outer membrane proteins responsible for multiple drug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 39, 645-649.
9. Poole, K., Tetro, K., Zhao, Q., Neshat, S., Heinrichs, D.E. and Bianco, N. (1996) Expression of the multidrug resistance operon mexA-mexB-oprM in Pseudomonas aeruginosa: mexR encodes a regulator of operon expression. Antimicrob. Agents Chemother. 40, 2021-2028.
10. Zhao, Q., Li, X.Z., Mistry, A., Srikumar, R., Zhang, L., Lomovskaya, O. and Poole, K. (1998) Influence of the TonB energy-coupling protein on efflux-mediated multidrug resistance in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 42, 2225-2231.
11. Poole, K. (1994) Bacterial multidrug resistance - emphasis on efflux mechanisms and Pseudomonas aeruginosa. J. Antimicrob. Chemother. 34, 453-456.
12. Masuda, N. and Ohya, S. (1992) Cross-resistance to meropenem, cephems, and quinolones in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 36, 1847-1851.
13. Gambello, M.J. and Iglewski, B.H. (1991) Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression. J. Bacteriol. 173, 3000-3009.
14. DeVries, C.A. and Ohman, D.E. (1994) Mucoid-to-nonmucoid conversion in alginate-producing Pseudomonas aeruginosa often results from spontaneous mutations in algT, encoding a putative alternate sigma factor, and shows evidence for auto-regulation. J. Bacteriol. 176, 6677-6687.
15. Simpson, D.A., Ramphal, R. and Lory, S. (1992) Genetic analysis of Pseudomonas aeruginosa adherence: distinct genetic loci control attachment to epithelial cells and mucins. Infect. Immun. 60, 3771-3779.
16. Poole, K., Neshat, S. and Heinrichs, D. (1991) Pyoverdine-mediated iron transport in Pseudomonas aeruginosa: involvement of a high-molecular-mass outer membrane protein. FEMS Microbiol. Lett. 62, 1-5.
17. Srikumar, R., Kon, T., Gotoh, N. and Poole, K. (1998) Expression of Pseudomonas aeruginosa multidrug efflux pumps MexA-MexB-OprM and MexC-MexD-OprJ in a multidrug-sensitive Escherichia coli strain. Antimicrob. Agents Chemother. 42, 65-71.
18. Pesci, E.C., Pearson, J.P., Seed, P.C. and Iglewski, B.H. (1997) Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa. J. Bacteriol. 179, 3127-3132.
19. Pesci, E.C. and Iglewski, B.H. (1997) The chain of command in Pseudomonas quorum sensing. Trends Microbiol. 5, 132-134.