Evaluation of 2-depxy-D-glucose for induction of a stress response in pigs

American Journal of Veterinary Research

Volumn 60, Issue 6, 1999, Pages 708-713

  Stabel, Thomas J ^a  

^a NATIONAL ANIMAL DISEASE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; DEOXYGLUCOSE; GLUCOSE; HYDROCORTISONE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; FEMALE; IMMUNOMODULATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTE PROLIFERATION; MALE; NONHUMAN; STRESS; SUBCUTANEOUS DRUG ADMINISTRATION; SWINE;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DEOXYGLUCOSE; FEMALE; HYDROCORTISONE; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; SALMONELLA; SPECIFIC PATHOGEN-FREE ORGANISMS; STRESS; SWINE; TIME FACTORS;

ANIMALIA; RODENTIA; SALMONELLA; SUIDAE; SUS SCROFA;

EID: 0033002388     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Dunn AJ, Berridge CW. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress responses? Brain Res Rev 1990;15: 71-100.
2. Jensen-Waern M, Nyberg L. Valuable indicators of physical stress in porcine plasma. J Vet Med 1993;40:321-327.
3. Clarke BL, Bost KL. Differential expression of functional adrenocortocotropic hormone receptors by subpopulations of lymphocytes. J Immunol 1989;143:464-469.
4. Goodwin JS, Messner RP, Williams RC. Inhibitors of T-cell mitogenesis: effect of mitogen dose. Cell Immunol 1979;45:303-308.
5. Munck A, Guyre PM, Holbrook MJ. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev 1984;5:25-44.
6. Flaming KP, Goff BL, Frank DE, et al. Pigs are relatively resistant to dexamethasone induced immunosuppression. Comp Haematol Int 1994;4:218-225.
7. Ruel JM, DeKloet ER. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology 1985;117:2505-2511.
8. Miller AH, Spencer RL, Trestman RL, et al. Adrenal steroid receptor binding in spleen and thymus after stress or dexamethasone. Am J Physiol 1990;259:405-412.
9. Cunnick JE, Lysle DT, Kucinski BJ. Stress-induced alteration of immune function: Diversity of effects and mechanisms. Ann N Y Acad Sci 1992;650:283-287.
10. Landau BR, Lubs HA. Animal responses to 2-deoxy-D-glucose administration. Proc Soc Exp Biol Med 1958;99:124-127.
11. Weidenfeld J, Corcos AP, Wohlman A, et al. Characterization of the 2-deoxyglucose effect on the adrenocortical axis. Endocrinology 1994;134:1924-1931.
12. Lysle DT, Cunnick JE, Wu R, et al. 2-Deoxy-D-glucose modulation of T-lymphocyte reactivity: differential effects on lymphoid compartments. Brain Behav Immun 1988;2:212-221.
13. Chou S-H, Kojic LD, Messingham KN, et al. Characterization of the effect of 2-deoxy-D-glucose (2-DG) on the immune system. Brain Behav Immun 1996;10:399-416.
14. Miller ES, Klinger JC, Akin C, et al. Inhibition of murine splenic T lymphocyte proliferation by 2-deoxy-D-glucose-induced metabolic stress. J Neuroimmunol 1994;52:165-173.
15. Miller ES, Koebel DA, Sonnenfeld G. The metabolic stressor 2-deoxy-D-glucose (2-DG) enhances LPS-stimulated cytokine production in mice. Brain Behav Immun 1993;7:317-325.
16. Johnson RW, von Borell EH, Anderson LL, et al. Intracerebroventricular injection of corticotropin-releasing hormone in the pig: acute effects on behavior, adrenocorticotropin secretion, and immune suppression. Endocrinology 1994;135:642-648.
17. Sonnenfeld G, Cunnick JE, Armfield AV, et al. Stress-induced alterations in Interferon production and class 11 histocompatibility antigen expression. Brain Behav Immun 1992;6:170-178.
18. Westly HJ, Kelley KW. Physiologic concentrations of cortisol suppress cell-mediated immune events in the domestic pig. Proc Soc Exp Biol Med 1984;177:156-164.
19. Dougherty RW Cannulation of arteries and veins. In: Dougherty RW, ed. Experimental surgery in farm animals. Ames, Iowa: Iowa State University Press, 1981;56-68.
20. McGlone JJ, Salak JL, Lumpkin EA, et al. Shipping stress and social status effects on pig performance, plasma cortisol, natural killer cell activity, and leukocyte numbers. J Anim Sci 1993;71: 888-896.
21. Janssens CJJG, Helmond FA, Wiegant VM. Increased cortisol response to exogenous adrenocorticotropic hormone in chronically stressed pigs: influence of housing conditions. J Anim Sci 1994; 72:1771-1777.
22. Ukeles R. Effect of hexose analogs on growth of Chilomonas paramecium. J Protozool 1970;17:220-223.
23. Franklund CV, Glass TL. Glucose uptake by the cellulolytic ruminai anaerobe Bacteroides succinogenes. J Bacteriol 1987;169:500-506.
24. Berends BR, Urlings HAP, Snijders JMA, et al. Identification and quantification of risk factors in animal management and transport regarding Salmonella spp. in pigs Int J Food Microbiol 1996; 30:37-53.