Neural circuits underlying ketamine-induced oculomotor behavior in the rat: 2-deoxyglucose studies

Experimental Brain Research

Volumn 124, Issue 1, 1999, Pages 8-16

  Porro, C A ^a   Biral, G P ^b   Benassi, C ^b   Cavazzuti, M ^b   Baraldi, P ^b   Lui, F ^b   Corazza, R ^b  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

Cerebral metabolism; Ketamine; Neural integrator; Oculomotor cortex; Saccadic eye movements

Indexed keywords

DEOXYGLUCOSE; KETAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN STEM; CEREBELLUM; CEREBELLUM VERMIS; CINGULATE GYRUS; CONTROLLED STUDY; EYE MOVEMENT CONTROL; FRONTAL CORTEX; MALE; METABOLIC BALANCE; NONHUMAN; NYSTAGMUS; OCULOMOTOR NERVE; PRIORITY JOURNAL; RAT; RETICULAR FORMATION; SACCADIC EYE MOVEMENT; SUBCUTANEOUS DRUG ADMINISTRATION; SUPERIOR COLLICULUS; VESTIBULAR NUCLEUS; VISUAL FIELD;

ANESTHETICS, DISSOCIATIVE; ANIMALS; ANTIMETABOLITES; BLOOD GAS ANALYSIS; BLOOD GLUCOSE; BRAIN STEM; CARBON RADIOISOTOPES; DEOXYGLUCOSE; FIXATION, OCULAR; KETAMINE; MALE; MOTOR NEURONS; NEURAL INHIBITION; OCULOMOTOR NERVE; RATS; RATS, LONG-EVANS; SACCADES;

EID: 0033001912     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210050594     Document Type: Article

References (53)

1. Beckstead RM (1979) An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal-projection (prefrontal) cortex in the rat. J Comp Neurol 184: 43-62
2. Biral GP, Cavazzuti M, Porro C, Ferrari R, Corazza R (1984) [14C]Deoxyglucose uptake of the rat visual centres under monocular optokinetic stimulation. Behav Brain Res 11:271-275
3. Biral GP, Benassi C, Lui F, Corazza R (1994) Spatio-temporal pattern of eye movements induced by ketamine in the rat. In: d'Ydewalle G, van Ransbergen J (eds) Visual and oculomotor functions: advances in eye movements research. North Holland, Amsterdam, pp 315-324
4. Bon L, Lucchetti C (1990) Does attention affect the motor programs of pharmacologically induced eye movements? Int J Neurosci 53:103-109
5. Cannon SC, Robinson DA (1987) Loss of the neural integrator of the oculomotor system from brain stem lesions in monkey. J Neurophysiol 57:1383-1406
6. Carlsson M, Carlsson A (1990) Schizophrenia: a subcortical neurotransmitter imbalance syndrome? Schizophrenia Bull 16: 425-432
7. Cavazzuti M, Porro CA, Biral GP, Benassi C, Barbieri GC (1987) Ketamine effects on local cerebral blood flow and metabolism in the rat. J Cereb Blood Flow Metab 7:806-811
8. Chelazzi L, Rossi F, Tempia F, Ghirardi M, Strata P (1989) Saccadic eye movements and gaze holding in the head-restrained pigmented rat. Eur J Neurosci 1:639-646
9. Chelazzi L, Ghirardi M, Rossi F, Strata P, Tempia F (1990) Spontaneous saccades and gaze-holding ability in the pigmented rat. II. Effects of localized cerebellar lesions. Eur J Neurosci 2:1085-1094
10. Cheron G, Godaux E (1987) Disabling of the oculomotor neural integrator by kainic acid injections in the prepositus-vestibular complex of the cat. J Physiol 394:267-290
11. Ciriello J, Rohlicek CV, Poulsen RS, Polosa C (1982) Deoxy-glucose uptake in the rat thoracolumbar cord during activation of aortic baroreceptor afferent fibers. Brain Res 231:240-245
12. Donoghue JP, Wise SP (1982) The motor cortex of the rat: cytoarchitecture and microstimulation mapping. J Comp Neurol 212: 76-88
13. Drejer J, HonorèT (1987) Phenciclidine analogues inhibit NMDA-stimulated [3H]GABA release from cultured cortex neurons. Eur J Pharmacol 143:287-290
14. Fuchs AF, Kaneko CRS, Scudder CA (1985) Brainstem control of saccadic eye movements. Annu Rev Neurosci 8:307-337
15. Furman JMR, Crumrine PK, Reinmuth OM (1990) Epilectic nystagmus. Ann Neurol 27:686-688
16. Ghoneim MM, Hinrichs JV, Mewaldt SP, Petersen RC (1985) Ketamine: behavioral effects of subanesthetic doses. J Clin Psychopharmacol 5:70-77
17. Godaux E, Cheron G, Mettens P (1990) Ketamine induces failure of the oculomotor neural integrator in the cat. Neurosci Lett 116:162-167
18. Goldberg ME, Segraves MA (1989) The visual and parietal cortices. In: Wurtz RH, Goldberg ME (eds) Neurobiology of saccadic eye movements. Rev Oculomotor Res, vol III. Elsevier, Amsterdam, pp 283-313
19. Goldman-Rakic PS (1987) Circuitry of primate prefrontal cortex and regulation of behavior by representational memory. In: Plum F (ed) Higher functions of the brain. Handbook of physiology. Oxford University Press, New York, pp 373-417
20. Hall RD, Lindholm EP (1974) Organization of motor and somatosensory neocortex in the albino rat. Brain Res 66:23-38
21. Hepp K, Henn V, Vilis T, Cohen B (1989) Brainstem regions related to saccadic generation. The visual and parietal cortices. In: Wurtz RH, Goldberg ME (eds) Neurobiology of saccadic eye movements. Rev Oculomotor Res, vol III. Elsevier, Amsterdam, pp 105-212
22. Hikosaka O, Sakamoto M (1986) Neural activities in the monkey basal ganglia related to attention, memory and anticipation. Brain Dev 8:454-462
23. Hikosaka O, Wurtz R (1989) The basal ganglia. In: Wurtz RH, Goldberg ME (eds) Neurobiology of saccadic eye movements. Rev Oculomotor Res, vol III. Elsevier, Amsterdam, pp 257-281
24. Kaplan PW, Tusa RJ (1993) Neurophysiologic and clinical correlations of epilectic nystagmus. Neurology 43:2508-2514
25. Kasper HJ, Hess BJM, Dieringer N (1987) A precise and inexpensive magnetic field search coil system for measuring eye and head movements in small laboratory animals. J Neurosci Methods 19:115-124
26. Kikuchi T, Wang Y, Shinbori H, Sato K, Okumura F (1997) Effects of ketamine and pentobarbitone on acetylcholine release from the rat frontal cortex in vivo. Br J Anaesth 79:128-130
27. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Brenner JD, Heninger GR, Bowers MBJ, Charney DS (1994) Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans. Arch Gen Psychiatry 51:199-214
28. Leichnetz GR, Gonzalo-Ruiz A (1987) Collateralization of frontal eye field (medial precentral/anterior cingulate) neurons projecting to the paraoculomotor region, superior colliculus, and medial pontine reticular formation in the rat: a fluorescent double-labeling study. Exp Brain Res 68:355-364
29. Leigh RJ, Zee DS (1983) The neurology of eye movements. Davis, Philadelphia
30. Leonard CM (1969) The prefrontal cortex of the rat. I. Cortical projection of the mediodorsal nucleus. II. Efferent connections. Brain Res 12:321-343
31. Lodge D, Johnson KM (1990) Noncompetitive excitatory amino acid antagonists. Trends Pharmacol Sci 11:81-86
32. Lopez-Barneo J, Darlot C, Berthoz A, Baker R (1982) Neural activity in prepositus nucleus correlated with eye movement in the alert cat. J Neurophysiol 47:329-352
33. McCulloch J, Iversen LL (1991) Autoradiographic assessment of the effects of N-methyl-D-aspartate receptor antagonists in vivo. Neurochem Res 16:951-963
34. Mettens P, Cheron G, Godaux E (1994) Involvement of the N-methyl-D-aspartate receptors of the vestibular nucleus in the gaze-holding system of the cat. Neurosci Lett 174:209-212
35. Moghaddam B, Adams B, Verma A, Daly D (1997) Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci 17:2921-2927
36. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA (1991) NMDA antagonists neurotoxicity: mechanism and prevention. Science 254:1515-1518
37. Øye I, Hustveit O, Maurset A, Moberg ER, Paulsen O, Skoglund LA (1991) The chiral forms of ketamine as probes for NMDA receptor functions in humans. In: Kameyama T, Nabeshina T, Domino EF (eds) NMDA receptor related agents, biochemistry, pharmacology and behaviour. NPP Books, Ann Arbor, pp 381-389
38. Øye I, Paulsen O, Maurset A (1992) Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors. J Pharmacol Exp Ther 260:1209-1213
39. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates. Academic, Press, Sydney
40. Petit L, Tzourio N, Orssaud C, Mazoyer B, Berthoz A (1994) Human functional anatomy of the fixation of a remembered visual target. Soc Neurosci Abstr 20:235
41. Porro CA, Carli G (1988) Immobilization and restraint effects on pain reactions in animals. Pain 32:289-307
42. Robinson DA (1968) Eye movement control in primates. Science 161:1219-1224
43. Schiller PH (1984) The superior colliculus and visual function. In: Brookhart JM, Mountcastle VB, Darian-Smith I, Geiger SR (eds) The nervous system. Handbook of physiology, vol III. American Physiological Society, Bethesda, pp 457-506
44. Sharkey J, Ritchie IM, Butcher SP, Kelly JS (1996) Comparison of the patterns of altered cerebral glucose utilisation produced by competitive and non-competitive NMDA receptor antagonists. Brain Res 735:67-82
45. Sokoloff L (1983) Measurement of local glucose utilization in the central nervous system and its relationship to local functional activity. In: Lajtha A (ed) Handbook of neurochemistry, vol 3. Plenum, Press, New York, pp 225-257
46. Sokoloff L, Reivich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M (1977) The 14C-deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897-931
47. Sparks DL (1986) Translation of sensory signals into commands for control of saccadic eye movements: role of primate superior colliculus. Physiol Rev 6:118-171
48. Stuesse SL, Newman DB (1990) Projections from the medial agranular cortex to brain stem visuomotor centers in rats. Exp Brain Res 80:532-544
49. Thurston SE, Leigh RJ, Osorio I (1985) Epileptic gaze deviation and nystagmus. Neurology 35:1518-1521
50. Vollenweider FX, Leenders KL, Scharfetter C, Antonini A, Maguire P, Missimer J, Angst J (1997) Metabolic hyperfrontality and psychopathology in the ketamine model of psychosis using positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG). Eur Neuropsychopharmacol 7:9-24
51. Wong EHF, Kemp JA, Priestly T, Knight AR, Woodruff GN, Iversen LL (1986) The anticonvulsant MK801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 83:7104-7108
52. Zee DS, Yamazaki A, Butler PH, Gücer G (1981) Effects of ablation of flocculus and paraflocculus on eye movements in primate. J Neurophysiol 46:878-899
53. Zilles K (1985) The cortex of the rat: a stereotaxic atlas. Springer, Berlin Heidelberg New York