Synthesis of 5-phenyl-10-methyl-7H-pyrimido[4,5-f][1,2,4]triazolo[4,3- a][1,4]diazepine and its evaluation as an anticonvulsant agent

Canadian Journal of Chemistry

Volumn 77, Issue 2, 1999, Pages 216-222

  Phillips, Oludotun A ^a   Murthy, K S Keshava ^b   Fiakpui, Charles Y ^a   Knaus, Edward E ^c  

^a NAEJA Pharmaceutical Inc   (Canada)

^b Brantford Chemicals Inc   (Canada)

^c UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Anticonvulsants; Homolytic benzoylation; Pyrimidines; Pyrimidodiazepines

Indexed keywords

5 PHENYL 10 METHYL 7H PYRIMIDO[4,5 F][1,2,4]TRIAZOLO[4,3 A][1,4]DIAZEPINE; ANTICONVULSIVE AGENT; CLONAZEPAM; PENTETRAZOLE; PYRIMIDINE; PYRIMIDODIAZEPINE; UNCLASSIFIED DRUG; VALPROIC ACID;

ANTICONVULSANT ACTIVITY; ARTICLE; CATALYSIS; CHEMICAL REACTION; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ELECTRIC SHOCK; REACTION ANALYSIS;

EID: 0033001424     PISSN: 00084042     EISSN: None     Source Type: Journal    
DOI: 10.1139/v98-221     Document Type: Article

References (17)

1. L.O. Randall, W. Schallek, L.H. Sternbach, and R.Y. Ning. In Psychopharmacological agents. Edited by M. Gordon. Academic Press. New York. 1974. pp. 175-281.
2. L.H. Sternbach. J. Med. Chem. 22, 1 (1979).
3. M. Williams. J. Med. Chem. 26, 619 (1983), and refs. cited therein.
4. C.Y. Fiakpui, O.A. Phillips, K.S.K. Murthy, and E.E. Knaus. Drug Des. Discovery, 10, 45 (1993).
5. C.Y. Fiakpui and E.E. Knaus. Drug Des. Discovery, 10, 173 (1993).
6. C.Y. Fiakpui and E.E. Knaus. Can. J. Chem. 65, 1158 (1987).
7. C.Y. Fiakpui, M.N. Namchuk, and E.E. Knaus. Drug Des. Delivery, 6, 111 (1990).
8. T.J. Kress. J. Org. Chem. 44, 2081 (1979).
9. G.R. Newkome and D.C. Hager. J. Org. Chem. 47, 599 (1982).
10. T. Kauffmann, B. Greving, J. Konig, A. Mitschker, and A. Woltermann. Angew. Chem. Intl. Ed. Engl. 14, 713 (1973).
11. T. Caronna, G.P. Gardini, and F. Minisci. Chem. Commun. 201 (1969).
12. T. Caronna, G. Fronza, F. Minisci, and O. Porta. J. Chem. Soc. Perkin Trans. 2, 1477 (1972).
13. G. Heinisch and G. Lotsch. Angew. Chem. Intl. Ed. Engl. 24, 692 (1985).
14. Y. Houminer, E.W. Southwick, and D.L. Williams. J. Org. Chem. 54, 640 (1989).
15. Y. Houminer, E.W. Southwick, and D.L. Williams. J. Heterocyl. Chem. 23, 497 (1986).
16. G.P. Gardini and F. Minisci. J. Chem. Soc. C, 929 (1970).
17. N. Whittaker. J. Chem. Soc. 1565 (1951).