κ-Opioid receptor antisense oligonucleotide injected into rat hippocampus causes hypertension

European Journal of Pharmacology

Volumn 377, Issue 1, 1999, Pages 57-61

  Wright, Rebecca C ^a   McConnaughey, Mona M ^a   Phan, Tu A ^a   Ingenito, Alphonse J ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

Author keywords

Opioid receptor; Antisense oligonucleotide; Blood pressure; Hippocampus

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; KAPPA OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; HIPPOCAMPUS; HYPERTENSION; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOASSAY; RAT; RECEPTOR DENSITY; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BINDING, COMPETITIVE; BLOOD PRESSURE; HIPPOCAMPUS; HYPERTENSION; MALE; MICROINJECTIONS; OLIGONUCLEOTIDES, ANTISENSE; RADIOLIGAND ASSAY; RATS; RATS, INBRED SHR; RATS, INBRED WKY; RECEPTORS, OPIOID, KAPPA; SYSTOLE;

EID: 0033001143     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00410-0     Document Type: Article

References (24)

1. Adams J.U., Chen X., DeRiel J.K., Adler M.W., Liu-Chen L.Y. Intracerebroventricular treatment with an antisense oligonucleotide to a kappa opioid receptor, inhibited kappa-agonist induced analgesia in rats. Brain Res. 667:1994;129-132.
2. Agrawal S., Temsamani J., Galbraith W., Tang J. Pharmacokinetics of antisense oligonucleotides. Clin. Pharmacokinet. 28(1):1995;7-16.
3. Akhtar S., Agrawal S. In vivo studies with antisense oligonucleotides. Trends Pharmacol. Sci. 18:1997;12-18.
4. Bhargava H.N., Das S. Selective proliferation of brain kappa opiate receptors in spontaneously hypertensive rats. Life Sci. 39:1986;2593-2600.
5. Calaresu, F.R., Ciriello, J., Caverson, M.M., Cechetto, D.F., Krukoff, T.L., 1984. Functional neuroanatomy of central pathways controlling the circulation. In: Guthriw, G.P., Kotchen, T.A. (Eds.), Hypertension and the Brain, Future Publishing, New York, p. 3.
6. Chien C.C., Brown G., Pan Y.X., Pasternak G.W. Blockade of U50,488H analgesia by antisense oligonucleotides to a kappa-opioid receptor. Eur. J. Pharmacol. 253:1994;R7-R8.
7. Corbett A.D., Peterson S.J., McKnight A.J., Magnan J., Kosterlitz H.W. Dynorphin 1-8 and dynorphin 1-9 are ligands for the kappa subtype of opiate receptor. Nature. 299:1982;79-81.
8. Feuerstein G., Siren A.L. Cardiovascular effects of enkephalins. ISI Atlas Sci. Pharmacol. 1:1987;280.
9. Helene C. Rational design of sequence specific oncogene inhibitors based on antisense and antigene oligonucleotides. Eur. J. Cancer. 27:1991;1466-1471.
10. Li S.J., Wong S.C., Ingenito A.J. A low hippocampal dynorphin A (1-8). Immunoreactivity in spontaneously hypertensive rats. Neuropeptides. 13:1989;197-200.
11. Lowry O.H., Rosenborough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265.
12. Matteucci M.D., Wagner R.W. In pursuit of antisense. Nature. 384:1996;20-22.
13. 2-opioid receptors after chronic treatment with non-peptide κ-agonists. J. Pharm. Pharmacol. 50:1998;1121-1125.
14. McGinty J., Henriksen S., Goldstein A., Terenius L., Bloom F. Dynorphin is contained within hippocampal mossy fibre systems: immunocytochemical alterations after kainic acid administration and colchicine induced neurotoxicity. Proc. Natl. Acad. Sci. U.S.A. 80:1983;593-598.
15. Nyce J.W., Metzger W.J. DNA antisense therapy for asthma in an animal model. Nature. 385:1997;721-725.
16. Papez J.W. A proposed mechanism of emotion, 1937 (classical article). Neuropsych. Clin. Neurosci. 7:1995;103-112.
17. Pasternak G.W., Standifer K.M. Mapping of opioid receptors using oligonucleotides: correlating their molecular biology and pharmacology. Trends Pharmacol. Sci. 16:1994;344-350.
18. Pasternak G.W., Childers S.R., Snyder S.H. Naloxone, a long acting opiate antagonist: effects on analgesia in intact animals and on opiate receptor binding in vitro. J. Pharmacol. Exp. Ther. 214:1980;455-462.
19. Peters G., Gaylor S. Human central nervous system effects of a selective kappa opioid agonist. Clin. Pharmacol. Ther. 45:1989;130.
20. Privette T.H., Wang J.Q., Ingenito A.J., Terrian D.M. Dentate granule cells as a central cardioregulatory site in the rat. Brain Res. 656:1994;295-301.
21. Tonkinson J.C., Stein C.A. Antisense oligonucleotides as clinical therapeutic agents. Cancer Invest. 14:1996;54-65.
22. Wahlestedt C. Antisense oligonucleotides: strategies in neuropharmacology. Trends Pharmacol. Sci. 15:1994;42-46.
23. Wang J.Q., Ingenito A.J. Cardiovascular responses to intrahippocampal dynorphin A (1-8) in spontaneously hypertensive rats. Eur. J. Pharmacol. 256:1994;57-64.
24. Zhai Q.Z., Ingenito A.J. Sustained antihypertensive effects of chronic administration of two kappa-opioid agonists in spontaneously hypertensive rats. Am. J. Ther. 4:1997;173-180.