The experimental study of the effects of ligustrazine on the blood serum endothelin (SET) and on the expression of ET-1 of the lung and ET(A)-RmRNA of the pulmonary vascular smooth muscle cells (PVSMC) in hypoxic rats

Chinese Pharmaceutical Journal

Volumn 34, Issue 1, 1999, Pages 17-20

  Tang, Taiqin ^a   Huang, Nasi ^a   Chen, Shufen ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

Author keywords

Anoxia; Endothelin(A); ET(A) RmRNA; Immunohistochemical staining; In situ hybridization; Ligustrazine; Pulmonary hypertension

Indexed keywords

ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; MESSENGER RNA; TETRAMETHYLPYRAZINE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG; LUNG BLOOD VESSEL; LUNG PARENCHYMA; MESSENGER RNA SYNTHESIS; NONHUMAN; PULMONARY HYPERTENSION; RADIOIMMUNOASSAY; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

EID: 0033001010     PISSN: 10012494     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Herbert Y L, Eugene H K, Glen K W, et al. Cloning and functional expression of a vascular smooth muscle endothelin-1 receptor. Proc Natl Acad Sci USA, 1991, 88(4):3185.
2. Luscher TF. Endothelin: Systemic arterial and pulmonary effects of as new peptide with potent biologic properties. Am Rev Respir Dis, 1992, 146(Suppl):46.
3. Hay DW, Hubbard Wc, Undoem BI. Endothelin induced contraction and mediator release in human bronchus. BrJ Pharmacol, 1993, 110:392.
4. Kourembanas S, Marsden PA. Hypoxia induces endothelin gene expression and secretion in cultured humman endothelium. J Clin Invest, 1991, 88:1054.