Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release

Japanese Journal of Pharmacology

Volumn 79, Issue 2, 1999, Pages 237-241

  Tsushima, Hiromi ^a   Mori, Mayumi ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Capsaicin; Neurokinin 1 receptor; Substance P; Supraoptic nucleus; Vasopressin

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; ACETYLCHOLINE; ARGIPRESSIN DERIVATIVE; ATROPINE; CAPSAICIN; NEUROKININ 1 RECEPTOR; PHENOXYBENZAMINE; SUBSTANCE P; TIMOLOL; VASOPRESSIN;

ANIMAL EXPERIMENT; ANTIDIURESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HYPOTHALAMUS; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NEUROHYPOPHYSIS; NONHUMAN; RAT; SUPRAOPTIC NUCLEUS; URINE VOLUME;

EID: 0032999759     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.79.237     Document Type: Article

References (23)

1. Bittencourt JC, Benoit R and Sawchenko PE: Distribution and origins of substance P-immunoreactive projections to the paraventricular and supraoptic nuclei: partial overlap with ascending catecholaminergic projections. J Chem Neuroanatomy 4, 63-78 (1991)
2. Larsen PJ, Jessop DS, Chowdrey HS, Mikkelsen JD and Lightman SL: Osmotic regulation of substance P and neurokinin A peptide content and substance P binding sites in distinct hypothalamic nuclei of the rat. Peptides 13, 705-712 (1992)
3. Eguchi T, Takano Y, Hatae T, Saito R, Nakayama Y, Shigeyoshi Y, Okamura H, Krause JE and Kamiya H: Antidiuretic action of tachykinin NK-3 receptor in the rat paraventricular nucleus. Brain Res 743, 49-55 (1996)
4. Heike Y, Hisano S, Tsuruo Y, Katih S and Daikoku S: Immunohistochemical evidence for synaptic regulation of paraventricular vasopressin-containing neurons by substance P. Brain Res 369, 341-346 (1986)
5. Massi M, Saija A, Polodori C, Perfumi M, Gentili L, Dost G and De Caro G: The hypothalamic paraventricular nucleus is a site of action for the central effect of tachykinins on plasma vasopressin. Brain Res Bull 26, 149-154 (1991)
6. Mori M, Tsushima H and Matsuda T: Substance P injected into the hypothalamic supraoptic nucleus causes antidiuresis through the release of arginine-vasopressin in water-loaded and ethanol-anesthetized rats. Jpn J Pharmacol 62, 49-56 (1993)
7. Dray A: Neuropharmacological mechanisms of capsaicin and related substances. Biochem Pharmacol 44, 611-615 (1992)
8. Holzer P: Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev 43, 143-201 (1991)
9. 2-terminus of substance P. J Pharmacol Exp Ther 268, 785-790 (1994)
10. 3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. Life Sci 59, 1899-1908 (1996)
11. Bigi S, De Acetis L, De Simone R, Aloe L and Alleva E: Neonatal capsaicin exposure affects isolation-induced aggressive behavior and hypothalamic substance P levels of adult male mice (Mus musculus). Behav Neurosci 107, 363-369 (1993)
12. König JFR and Klippel RA: The Rat Brain, a Stereotaxic Atlas of the Forebrain and Lower Parts of the Brain Stem. Williams and Wilkins Co, Baltimore (1963)
13. Tsushima H, Mori M and Matsuda T: Adrenergic neural connections between the bilateral supraoptic nuclei of the rat hypothalamus. Jpn J Pharmacol 71, 73-79 (1996)
14. 5-enkephalin, microinjected into the supraoptic and paraventricular nuclei, on urine outflow rate. Jpn J Pharmacol 63, 181-186 (1993)
15. Mori M, Tsushima H, Kamiya T and Matsuda T: Effect of muscarinic receptor modulators in the hypothalamic supraoptic nucleus of the rat. Jpn J Pharmacol 66, 413-419 (1994)
16. 1) receptor. Science 251, 435-437 (1991)
17. Betancur C, Azzi M and Rostene W: Nonpeptide antagonists of neuropeptides receptors: tools for research and therapy. Trends Pharmacol Sci 18, 372-386 (1997)
18. Mori M, Tsushima H and Matsuda T: Antidiuretic effects of oxotremorine microinjected into the hypothalamic supraoptic and paraventricular nuclei in a water-loaded and ethanol-anesthetized rat. Jpn J Pharmacol 35, 27-36 (1984)
19. Tsushima H, Mon M and Matsuda T: Antidiuretic effects of alpha- and beta-adrenoceptor agonists microinjected into the hypothalamic supraoptic nucleus in a water-loaded and ethanol-anesthetized rat. Jpn J Pharmacol 39, 365-374 (1985)
20. Saigo A, Takano Y, Matsumoto T, Tran M, Nakayama Y, Saito R, Yamada K and Kamiya H: Central administration of senktide, a tachykinin NK-3 agonist, has an antidiuretic action by stimulating AVP release in water-loaded rats. Neurosci Lett 159, 187-190 (1993)
21. Yuan YD and Couture R: Renal effects of intracerebroventricularly injected tachykinin in the conscious saline-loaded rat: receptor characterization. Br J Pharmacol 120, 785-796 (1997)
22. Polidori C, Saija A, Peerfumi M, Costa G, de Caro G and Massi M: Vasopressin release induced by intracranial injection of tachykinins is due to activation of central neurokinin-3 receptors. Neurosci Lett 103, 320-325 (1989)
23. Mori M, Tsushima H and Matsuda T: Effect of vasopressin antagonist on antidiuresis by oxotremorine microinjected into the hypothalamic supraoptic and paraventricular nuclei in a water-loaded and ethanol-anesthetized rat. Jpn J Pharmacol 49, 357-364 (1989)