Regulation of recombinant cardiac cystic fibrosis transmembrane conductance regulator chloride channels by protein kinase C

Biophysical Journal

Volumn 76, Issue 4, 1999, Pages 1972-1987

  Yamazaki, Jun ^a,b   Britton, Fiona ^a   Collier, Mei Lin ^a,c   Horowitz, Burton ^a   Hume, Joseph R ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b FUKUOKA DENTAL COLLEGE   (Japan)

^c UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORIDE CHANNEL; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE C; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CHELATION; CHLORIDE CURRENT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FEMALE; INTRACELLULAR RECORDING; MEMBRANE CURRENT; NONHUMAN; OOCYTE; REGULATORY MECHANISM; SITE DIRECTED MUTAGENESIS; VOLTAGE CLAMP; XENOPUS;

EID: 0032999730     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3495(99)77356-X     Document Type: Article

References (50)

1. Bahinski, A., A. C. Nairn, P. Greengard, and D. C. Gadsby. 1989. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes. Nature. 340:718-721.
2. - channel activity in Xenopus oocytes expressing the cystic fibrosis gene. J. Biol. Chem. 266:19142-19145.
3. - channel by specific protein kinases and protein phosphatases. J. Biol. Chem. 268: 2037-2047.
4. Bourinet, E., F. Fournier, P. Lory, P. Chamet, and J. Nargeot. 1992. Protein kinase C regulation of cardiac calcium channels expressed in Xenopus oocytes. Pflugers Arch. 421:247-255.
5. Collier, M. L., and J. R. Hume. 1995. Unitary chloride channels activated by protein kinase C in guinea pig ventricular myocytes. Circ. Res. 76:317-324.
6. Dechecchi, M. C., R. Rolfini, A. Tamanini, C. Gamberi, G. Berton, and G. Cabrini. 1992. Effect of modulation of protein kinase C on the cAMP-dependent chloride conductance in T84 cells. FEBS Lett. 311:25-28.
7. Delaney, S. J., D. P. Rich, S. A. Thomson, M. R. Hargrave, P. K. Lovelock, M. J. Welsh, and B. J. Wainwright. 1993. Cystic fibrosis transmembrane conductance regulator splice variants are not conserved and fail to produce chloride channels. Nature Genet. 4:426-431.
8. - channel opening and closing rates, confirming hydrolysis of two ATP molecules per gating cycle. Biophys. J. 70:A127.
9. Drumm, M. L., D. J. Wilkinson, L. S. Smit, R. T. Worrell, T. V. Strong, R. A. Frizzell, D. C. Dawson, and F. S. Collins. 1991. Chloride conductance expressed by delta F508 and other mutant CFTRs in Xenopus oocytes. Science. 254:1797-1799.
10. Dulhanty, A. M., and J. R. Riordan. 1994. Phosphorylation by cAMP-dependent protein kinase causes a conformational change in the R domain of the cystic fibrosis transmembrane conductance regulator. Biochemistry. 33:4072-4079.
11. Ehara, T., and K. Ishihara. 1990. Anion channels activated by adrenaline in cardiac myocytes. Nature. 347:284-286.
12. Fischer, H., B. Illek, and T. E. Machen. 1998. Regulation of CFTR by protein phosphatase 2B and protein kinase C. Pflugers Arch. 436: 175-181.
13. Foskett, J. K. 1998. CIC and CFTR chloride channel gating. Annu. Rev. Physiol. 60:689-717.
14. Gadsby, D. C., T. C. Hwang, M. Horie, G. Nagel, and A. C. Nairn. 1993. Cardiac chloride channels: incremental regulation by phosphorylation/dephosphorylation. Ann. N.Y. Acad. Sci. 707:259-274.
15. Gadsby, D. C., G. Nagel, and T. C. Hwang. 1995. The CFTR chloride channel of mammalian heart. Annu. Rev. Physiol. 57:387-416.
16. Gadsby, D. C., and A. C. Nairn. 1994. Regulation of CFTR channel gating. Trends. Biochem. Sci. 19:513-518.
17. ++-transport ATPase and of calmodulin-regulated functions. Biochem. Biophys. Res. Commun. 101:418-425.
18. Hart, P., J. D. Warth, P. C. Levesque, M. L. Collier, Y. Geary, B. Horowitz, and J. R. Hume. 1996. Cystic fibrosis gene encodes a cAMP-dependent chloride channel in heart. Proc. Natl. Acad. Sci. USA. 93:6343-6348.
19. Harvey, R. D., C. D. Clark, and J. R. Hume. 1990. Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential. J. Gen. Physiol. 95:1077-1102.
20. Harvey, R. D., and J. R. Hume. 1989. Autonomic regulation of a chloride current in heart. Science. 244:983-985.
21. Horowitz, B., S. S. Tsung, P. Hart, P. C. Levesque, and J. R. Hume. 1993. Alternative splicing of CFTR Cl channels in heart. Am. J. Physiol. 264:H2214-H2220.
22. Hume, J. R., and B. Horowitz. 1995. A plethora of cardiac chloride conductances: molecular diversity or a related gene family. J. Cardiovasc. Electrophysiol. 6:325-331.
23. - conductance in mammalian heart. J. Gen. Physiol. 101: 629-650.
24. Jia, Y., C. J. Mathews, and J. W. Hanrahan. 1997. Phosphorylation by protein kinase C is required for acute activation of cystic fibrosis transmembrane conductance regulator by protein kinase A. J. Biol. Chem. 272:4978-4984.
25. Jones, D. H., and B. H. Howard. 1991. A rapid method for recombination and site-specific mutagenesis by placing homologous ends on DNA using polymerase chain reaction. Biotechniques. 10:62-66.
26. Liu, J., J. D. J. Farmer, W. S. Lane, J. Friedman, I. Weissman, and S. L. Schreiber. 1991. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 66:807-815.
27. + current by protein kinase C and protein kinase A. Circ. Res. 83:995-1002.
28. Luo, J., M. D. Pato, J. R. Riordan, and J. W. Hanrahan. 1998. Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases. Am. J. Physiol. 274:C1397-C1410.
29. - channel function in guinea pig ventricular myocytes. Am. J. Physiol. 275:C293-C302.
30. Mond, J. J., N. Feuerstein, C. H. June, A. K. Balapure, R. L. Glazer, K. Witherspoon, and M. Brunswick. 1991. Bimodal effect of phorbol ester on B cell activation. J. Biol. Chem. 266:4458-4463.
31. - channel resembles the cystic fibrosis transmembrane conductance regulator. Nature. 360: 81-84.
32. Newton, A. C. 1996. Regulation of protein kinase C. Curr. Opin. Cell Biol. 9:161-167.
33. Nishizuki, Y. 1988. The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature. 334:661-665.
34. Ohno, S., Y. Akita, Y. Konno, S. Imajoh, and K. Suzuki. 1988. A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Cell. 53:731-741.
35. - current in guinea pig ventricular myocytes. Circ. Res. 78:1090-1099.
36. Parker, P. J., L. Bosca, L. Deckker, N. T. Goode, N. Hajibagheri, and G. Hansra. 1995. Protein kinase C (PKC)-induced PKC degradation: a model for down-regulation. Biochem. Soc. Trans. 23(1):153-155.
37. Picciotto, M. R., J. A. Cohn, G. Bertuzzi, P. Greengard, and A. C. Nairn. 1992. Phosphorylation of the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 267:12742-12752.
38. Shuba, L. M., T. Asai, and T. F. McDonald. 1996. Phorbol ester activation of chloride current in guinea-pig ventricular myocytes. Br. J. Pharmacol. 117:1395-1404.
39. Stemmer, P., and C. B. Klee. 1991. Serine/threonine phosphatases in the nervous system. Curr. Opin. Neurobiol. 1:53-64.
40. - channel in CHO cells stably expressing the cystic fibrosis gene. Nature. 352:628-631.
41. Travis, S. M., H. A. Berger, and M. J. Welsh. 1997. Protein phosphatase 2C dephosphorylates and inactivates cystic tlbrosis transmembrane conductance regulator. Proc. Natl. Acad. Sci. USA. 94:11055-11060.
42. Tsien, R. Y. 1980. New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19:2396-2404.
43. +-ATPase in oocytes of Xenopus laevis. J. Membr. Biol. 118:131-142.
44. Walsh, K. B. 1991. Activation of a heart chloride current during stimulation of protein kinase C. Mol. Pharmacol. 40:342-346.
45. Walsh, K. B., and K. J. Long. 1994. Properties of a protein kinase C-activated chloride current in guinea pig ventricular myocytes. Circ. Res. 74:121-129.
46. 2+-induced leak current in Xenopus oocytes is indeed mediated through a Cl channel. J. Membr. Biol. 148:263-275.
47. Wilkinson, D. J., M. K. Mansoura, P. Y. Watson, L. S. Smit, F. S. Collins, and D. C. Dawson. 1996. CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated state. J. Gen. Physiol. 107:103-119.
48. Xie, J., M. L. Drumm, J. Zhao, J. Ma, and P. B. Davis. 1996. Human epithelial cystic fibrosis transmembrane conductance regulator without exon 5 maintains partial chloride channel function in intracellular membranes. Biophys. J. 71:3148-3156.
49. Yamazaki, J., M. L. Collier, B. Horowitz, and J. R. Hume. 1997. Cross-regulation of cardiac (exon 5-) CFTR chloride channels by PKA and PKC in Xenopus oocytes. Biophys. J. 72:A226
50. - currents in feline ventricular myocytes. Circ. Res. 75:133-143.