Indolylquinoline derivatives are cytotoxic to Leishmania donovani promastigotes and amastigotes in vitro and are effective in treating murine visceral leishmaniasis

Journal of Antimicrobial Chemotherapy

Volumn 43, Issue 3, 1999, Pages 359-366

  Chakrabarti, Ganes ^a   Basu, Anirban ^a   Manna, Partha Pratim ^a   Mahato, Sashi Bhusahan ^a   Mandal, Nirup Bikash ^a   Bandyopadhyay, Santu ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2' ACETAMIDOBENZYL) 3 (3' INDOLYLQUINOLINE); 2 (2' AMINOBENZYL) 3 (3' INDOLYLQUINOLINE); 2 (2' CHLOROACETAMIDOBENZYL) 3 (3' INDOLYLQUINOLINE); 2 (2' DICHLOROACETAMIDOBENZYL) 3 (3' INDOLYLQUINOLINE); ANTIMONY GLUCONATE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACYLATION; AMASTIGOTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; LEISHMANIA DONOVANI; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROMASTIGOTE; SPLEEN; VISCERAL LEISHMANIASIS;

EID: 0032998656     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/43.3.359     Document Type: Article

References (17)

1. Anonymous. (1990). World Report on Tropical Diseases. Geneva, WHO.
2. Ashford, R. W., Desjeux, P. & Deraadt, P. (1992). Estimation of population at risk of infection and number of cases of leishmaniasis. Parasitology Today 8, 104-5.
3. Howard, J. G. (1986). Immunological regulation and control of experimental leishmaniasis. International Review of Experimental Pathology 28, 79-116.
4. Olliaro, P. & Bryceson, A. D. M. (1993). Practical progress and new drugs for changing patterns of leishmaniasis. Parasitology Today 9, 323-8.
5. Johnson, J. L. & Werbel, L. M. (1983). Synthesis and antileishmanial activity of 6-methoxy-4-methyl-N-[6-(substituted-1-piper-azinyl)hexyl]-8-quinolinamines and related compounds. Journal of Medicinal Chemistry 26, 185-94.
6. Kinnamon, K. E., Steck, E. A., Loizeaux, P. S., Hanson, W. L., Chapman, W. L. & Waits, V. B. (1978). The antileishmanial activity of lepidines. American Journal of Tropical Medicine and Hygiene 27, 751-7.
7. Ghosh, A. K., Rakshit, M. M. & Ghosh, D. K. (1983). Effect of berberine chloride on Leishmania donovani. Indian Journal of Medical Research 78, 407-16.
8. El-On, J., Jacobs, G. P. & Weinrauch, L (1988). Topical chemotherapy of cutaneous leishmaniasis. Parasitology Today 4, 76-81.
9. Vennerstrom, J. L., Lovelace, J. K., Waits, V. B., Hanson, W. L. & Klayman, D. L. (1990). Berberine derivatives as antileishmanial drugs. Antimicrobial Agents and Chemotherapy 34, 918-21.
10. Mahato, S. B., Mandal, N. B., Chattopadhyay, S., Nandi, G., Luger, P. & Weber, M. (1994). Synthesis of indolylquinolines under Friedel-Craft reaction condition. Tetrahedron 50, 10803-12.
11. Ghosh, A. K., Bhattacharyya, F. K. & Ghosh, D. K. (1985). Leishmania donovani: amastigote inhibition and mode of action of berberine. Experimental Parasitology 60, 404-13.
12. Jaffe, C. L., Grimaldi, G. & McMohan-Pratt, D. (1984). In Genes and Antigens of Parasites: A Laboratory Manual, 2nd edn (Morel, C. M., Ed.), p. 47. Fundacao Oswaldo Cruz, Rio de Janiero.
13. Boyum, A. (1968). Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulytes by combining centrifugation and sedimentation at 1g. Scandinavian Journal of Clinical and Laboratory Investigation Suppl. 97, 77-89.
14. Stauber, L. A., Franchino, E. M. & Grun, J. (1958). An eight-day method for screening compounds against Leishmania donovani in the golden hamster. Journal of Protozoology 5, 269-73.
15. Nabors, G. S. & Farrell, J. P. (1994). Depletion of interleukin-4 in BALB/c mice with established Leishmania major infections increases the efficacy of antimony therapy and promotes Th1-like responses. Infection and Immunity 62, 5498-504.
16. Iwu, M. M., Jackson, J. E. & Schuster, B. G. (1994). Medicinal plants in the fight against leishmaniasis. Parasitology Today 10, 65-8.
17. Ray, S., Sadhukhan, P. K., Mandal, N. B., Mahato, S. B. & Majumder, H. K. (1997). Dual inhibition of DNA topoisomerases of Leishmania donovani by novel indolyl quinolines. Biochemical and Biophysical Research Communications 230, 171-5.