A double-blind, multicentre study to assess the tolerability and efficacy of paroxetine compared with amitriptyline in the treatment of depressed patients in Australian general practice

Australian and New Zealand Journal of Psychiatry

Volumn 33, Issue 3, 1999, Pages 416-421

  Freed, Edgar ^b   Goldney, Robert ^c   Lambert, Timothy ^d   Tiller, John ^e   Johnston, Robyn ^a  

^a SmithKline Beecham International   (Australia)

^b ST VINCENT S HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d ST VINCENT S HOSPITAL   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Depression; Efficacy; General practice; Paroxetine; Tolerability

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; PAROXETINE;

ADULT; AGED; ARTICLE; AUSTRALIA; AUTONOMIC DYSFUNCTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; GENERAL PRACTICE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; RATING SCALE; SIDE EFFECT; STATISTICAL ANALYSIS;

ADULT; AGED; AGED, 80 AND OVER; AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANTIDEPRESSIVE AGENTS, TRICYCLIC; AUSTRALIA; CHI-SQUARE DISTRIBUTION; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; MALE; MIDDLE AGED; PAROXETINE; PRIMARY HEALTH CARE; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS; TREATMENT OUTCOME;

EID: 0032998311     PISSN: 00048674     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1614.1999.00565.x     Document Type: Article

References (10)

1. Beerworth EE, Tiller JWG. Liability in prescribing choice: the example of the antidepressants. Australian and New Zealand Journal of Psychiatry 1998; 32:560-566.
2. Thompson C, Thompson CM. The prescribing of anti-depressants in general practice. II: A placebo-controlled trial of low-dose dothiepin. Human Psychopharmacology 1989; 4:191-204.
3. Thompson C. Bridging the gap between psychiatric practice and primary care. International Clinical Psychopharmacology 1992; 7:31-36.
4. Hutchinson DR, Tong S, Moon CAL, Vince M, Clarke A. A double-blind study in general practice to compare the efficacy and tolerability of paroxetine and amitriptyline in depressed elderly patients. British Journal of Clinical Research 1991; 2:43-57.
5. Christiansen PE, Behnke K, Black CH, Ohrstrom JK, Bork-Rasmussen H, Nilsson J. Paroxetine and amitriptyline in the treatment of depression in general practice. Acta Psychiatrica Scandinavica 1996; 93:158-163.
6. Orrell M, Collins E, Shergill S, Katona C. Management of depression in the elderly by general practitioners: Use of antidepressants. Family Practice 1995; 12:5-17.
7. Freeling P. Diagnosis and treatment of depression in general practice. British Journal of Psychiatry 1993; 163:14-19.
8. Jacobson GA, Friesen WT, Peterson GM, Rumble RH, Polack AE. Psychoactive drug prescribing in the Tasmanian community. Medical Journal of Australia 1992; 157:20-22.
9. Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. British Journal of Psychiatry 1979; 134:382-389.
10. Moon CAL, Jago W, Wood K, Doogan DP. A double-blind comparison of sertraline and clomipramine in the treatment of major depressive disorder and associated anxiety in general practice. Journal of Psychopharmacology 1994; 8:171-176.