Differential regulation of muscarinic M1 and M3 receptors by a putative phosphorylation domain

European Journal of Pharmacology

Volumn 377, Issue 1, 1999, Pages 137-146

  Shockley, Melinda S ^a   Tolbert, Lara M ^a   Tobin, Andrew B ^c   Nahorski, Stefan R ^c   Sadée, Wolfgang ^a   Lameh, Jelveh ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MOLECULAR RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Desensitization; Down regulation; Internalization; Phosphoinositide hydrolysis; Phosphorylation; Receptor regulation

Indexed keywords

CARBACHOL; METHYLSCOPOLAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M3 RECEPTOR; PHOSPHATIDYLINOSITIDE;

ANIMAL CELL; ARTICLE; CHO CELL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DESENSITIZATION; HYDROLYSIS; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOPRECIPITATION; MUTANT; MUTATION; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION;

ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CARBACHOL; CHO CELLS; CRICETINAE; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION; HUMANS; INOSITOL 1,4,5-TRISPHOSPHATE; MICROSCOPY, CONFOCAL; MUSCARINIC AGONISTS; MUTATION; PHOSPHORYLATION; RADIOLIGAND ASSAY; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M3; RECEPTORS, CELL SURFACE; RECEPTORS, MUSCARINIC; TRANSFECTION;

EID: 0032998299     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00303-9     Document Type: Article

References (23)

1. Arden J.R., Nagata O., Shockley M.S., Philip M., Lameh J., Sadée W. Mutational analysis of third cytoplasmic loop domains in G-protein coupling of the Hm1 muscarinic receptor. Biochem. Biophys. Res. Commun. 188:1992;1111-1115.
2. Benovic J.L., Bouvier M., Caron M.G., Lefkowitz R.J. Regulation of adenylyl cyclase-coupled beta-adrenergic receptors. Ann. Rev. Cell Biol. 4:1988;405-428.
3. 2a-adrenergic receptor. J. Biol. Chem. 270:1995;4681-4688.
4. 2-adrenergic receptor sequestration. J. Biol. Chem. 270:1995;24782-24789.
5. Ferguson S.S., Downey W.E. III, Colapietro A.M., Barak L.S., Menard L., Caron M.G. Role of β-arrestin in mediating agonist-promoted G protein-coupled receptor internalization. Science. 271:1996;363-366.
6. Haga K., Kameyama K., Haga T., Kikkawa U., Shiozaki K., Uchiyama H. Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C. J. Biol. Chem. 271:1996;2776-2782.
7. Harden T.K., Petch L.A., Traynelis S.F., Waldo G.L. Agonist-induced alteration in the membrane form of muscarinic cholinergic receptors. J. Biol. Chem. 260:1985;13060-13066.
8. Koenig J.A., Edwardson J.M. Intracellular trafficking of the muscarinic acetylcholine receptor: importance of subtype and cell type. Mol. Pharmacol. 49:1996;351-359.
9. Maeda S., Lameh J., Mallet W., Philip M., Ramachandran J., Sadée W. Internalization of the Hm1 muscarinic cholinergic receptor involves the third cytoplasmic loop. FEBS Lett. 269:1990;386-388.
10. Moro O., Lameh J., Sadée W. Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors. J. Biol. Chem. 268:1993;6862-6865.
11. Nakata H., Kameyama K., Haga K., Haga T. Location of agonist-dependent phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype). Eur. J. Biochem. 220:1994;29-36.
12. Pals-Rylaarsdam R., Hosey M.M. Two homologous phosphorylation domains differentially contribute to desensitization and internalization of the m2 muscarinic acetylcholine receptor. J. Biol. Chem. 272:1997;14152-14158.
13. Pals-Rylaarsdam R., Xu Y., Witt-Enderby P., Benovic J.L., Hosey M.M. Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J. Biol. Chem. 270:1995;29004-29011.
14. Pals-Rylaarsdam R., Gurevich V.V., Lee K.B., Ptasienski J.A., Benovic J.L., Hosey M.M. Internalization of the m2 muscarinic acetylcholine receptor. J. Biol. Chem. 272:1997;23682-23689.
15. Schlador M.L., Nathanson N.M. Synergistic regulation of m2 muscarinic acetylcholine receptor desensitization and sequestration by G protein-coupled receptor kinase-2 and β-arrestin-1. J. Biol. Chem. 272:1997;18882-18890.
16. Shockley M.S., Burford N.T., Sadée W., Lameh J. Residues specifically involved in down-regulation but not internalization of the m1 muscarinic acetylcholine receptor. J. Neurochem. 68:1997;601-609.
17. Tobin A.B., Nahorski S.R. Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation. J. Biol. Chem. 268:1993;9817-9823.
18. Tobin A.B., Lambert D.G., Nahorski S.R. Rapid desensitization of muscarinic m3 receptor-stimulated polyphosphoinositide responses. Mol. Pharmacol. 42:1992;1042-1048.
19. Tobin A.B., Keys B., Nahorski S.R. Identification of a novel receptor kinase that phosphorylates a phospholipase C-linked muscarinic receptor. J. Biol. Chem. 271:1996;3907-3916.
20. Tolbert L.M., Lameh J. Human muscarinic cholinergic receptor Hm1 internalizes via clathrin-coated vesicles. J. Biol. Chem. 271:1996;17335-17342.
21. Wu G., Krupnick J.C., Benovic J.L., Lanier S.L. Interaction of arrestins with intracellular domains of muscarinic and α2-adrenergic receptors. J. Biol. Chem. 272:1997;17836-17842.
22. Yang J., Logsdon C.D., Johansen T.E., Williams J.A. Human m3 muscarinic acetylcholine receptor carboxyl-terminal threonine residues are required for agonist-induced receptor down-regulation. Mol. Pharmacol. 44:1993;1158-1164.
23. Yang J., Williams J.A., Yule D.I., Logsdon C.D. Mutation of carboxyl-terminal threonine residues in human m3 muscarinic acetylcholine receptor modulates the extent of sequestration and desensitization. Mol. Pharmacol. 48:1995;477-485.