Carbonyl-iron supplementation induces hepatocyte nuclear changes in BALB/CJ male mice

Journal of Hepatology

Volumn 30, Issue 5, 1999, Pages 926-934

  Pigeon, Christelle ^a   Turlin, Bruno ^a,b   Iancu, Theodore C ^c   Leroyer, Patricia ^a   Lan, Jacky Le ^d   Deugnier, Yves ^a,b   Brissot, Pierre ^a,b   Loréal, Olivier ^a  

^a INSERM   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^d Laboratoire d'A p Lan Naber   (France)

Author keywords

Cell proliferation; Ferritin; Hemochromatosis; Hepatocellular carcinoma; Iron overload

Indexed keywords

CARBONYL IRON; FERRITIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; HEMOCHROMATOSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IRON OVERLOAD; LIVER CELL CARCINOMA; LIVER FIBROSIS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032998038     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80149-4     Document Type: Article

References (48)

1. Basset M, Halliday JW, Powell L. Value of hepatic iron measurements in early hemochromatosis and determination of the critical iron level associated with fibrosis. Hepatology. 6:1986;24-29.
2. Niederau C, Fisher R, Sonnenberg A, Stremmel W, Trampisch HJ, Strohmeyer G. Survival and causes of death in cirrhotic and noncirrhotic patients with primary hemochromatosis. N Engl J Med. 313:1985;1256-1262.
3. Deugnier YM, Guyader D, Crantock L, Lopez JM, Turlin B, Yaouanq J, et al. Primary liver cancer in genetic hemochromatosis: a clinical, pathological, and pathogenetic study of 54 cases. Gastroenterology. 104:1993;228-234.
4. Fargion S, Mandelli C, Piperno A, Cesana B, Fracanzani AL, Fraquelli M, et al. Survival and prognostic factors in 212 Italian patients with genetic hemochromatosis. Hepatology. 15:1992;655-659.
5. Loréal O, Deugnier Y, Moirand R, Lauvin L, Guyader D, Jouanolle H, et al. Liver fibrosis in genetic hemochromatosis. Respective roles of iron and non-iron-related factors in 127 homozygous patients. J Hepatol. 16:1992;122-127.
6. Deugnier YM, Loréal O, Turlin B, Guyader D, Jouanolle H, Moirand R, et al. Liver pathology in genetic hemochromatosis: a review of 135 homozygous cases and their bioclinical correlations. Gastroenterology. 102:1992;2050-2059.
7. Niederau C, Fischer R, Purschel A, Stremmel W, Haussinger D, Strohmeyer G. Long-term survival in patients with hereditary hemochromatosis. Gastroenterology. 110:1996;1107-1119.
8. Risdon R, Barry M, Flynn D. Transfusional iron overload: the relationship between tissue iron concentration and hepatic fibrosis in thalassamia. J Pathol. 116:1975;83-95.
9. Schaffer AI, Cheron RG, Dluhy R, Cooper B, Gleason RE, Soeldner JS, et al. Clinical consequences of acquired transfusional iron overload in adults. N Engl J Med. 304:1981;319-324.
10. Stal P, Hultcranz R. Iron increases ethanol toxicity in rat liver. J Hepatol. 17:1993;108-115.
11. Olynyk JK, Reddy KR, Di Bisceglie AM, Jeffers LJ, Parker TI, Radick JL, et al. Hepatic iron concentration as a predictor of response to interferon alfa therapy in chronic hepatitis C. Gastroenterology. 108:1995;1104-1109.
12. Turlin B, Juguet F, Moirand R, Le Quilleuc D, Loréal O, Campion JP, et al. Increased liver iron stores in patients with hepatocellular carcinoma developed on a noncirrhotic liver. Hepatology. 22:1995;446-450.
13. Park CH, Bacon BR, Brittenham GM, Tavill AS. Pathology of dietary carbonyl-iron overload in rats. Lab Invest. 57:1987;555-563.
14. Stal P, Hultcrantz R, Moller L, Eriksson LC. The effects of dietary iron on initiation and promotion in chemical hepatocarcinogenesis. Hepatology. 21:1995;521-528.
15. Whittaker P, Hines FA, Robl MG, Dunkel VC. Histopathological evaluation of liver, pancreas, spleen and heart from iron-over-loaded Sprague-Dawley rats. Toxicol Pathol. 24:1996;558-563.
16. Hultcrantz R, Arborgh B. Studies on the rat liver following iron overload. Fine structural appearance. Acta Path Microbiol Scand Sect. 86:1978;143-155.
17. Iancu TC, Ward RJ, Peters TJ. Ultrastructural observations in the carbonyl-iron-fed rat, an animal model for hemochromatosis. Virchows Arch B. 53:1987;208-217.
18. Pietrangelo A, Rocchi E, Schiaffonati L, Ventura E, Cairo G. Liver gene expression during chronic dietary iron overload in rats. Hepatology. 11:1990;798-804.
19. Pietrangelo A, Gualdi R, Casalgrandi G, Geerts A, De Bleser P, Montosi G, et al. Enhanced hepatic collagen type I mRNA expression into fat-storing cells in a rodent model of hemochromatosis. Hepatology. 19:1994;714-721.
20. Roberts FD, Charalambous P, Fletcher L, Powell LW, Halliday JW. Effect of chronic iron overload on procollagen gene expression. Hepatology. 18:1993;590-595.
21. Rothenberg BE, Voland JR. Beta2 knockout mice develop parenchymal iron overload: a putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc Natl Acad Sci USA. 93:1996;1529-1534.
22. Bernstein SE. Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia. J Lab Clin Med. 110:1987;690-705.
23. Simpson RJ, Konijn AM, Lombard M, Raja KB, Salisbury JR, Peters TJ. Tissue iron loading and histopathological changes in hypotransferrinaemic mice. J Pathol. 171:1993;237-244.
24. De Sousa M, Reimao R, Lacerda R, Hugo P, Kaufmann SHE, Porto G. Iron overload in beta 2-croglobulin-deficient mice. Immunol Lett. 39:1994;105-111.
25. Santos M, Schilham MW, Rademakers LH, Marx JJM, de Sousa M, Clevers H. Defective iron homeostasis in beta2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man. J Exp Med. 184:1996;1975-1985.
26. Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed A, Jiang J, et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci USA. 95:1998;2492-2497.
27. Smith AG, Carthew P, Francis JE, Edwards RE, Dinsdale D. Characterization and accumulation of ferritin in hepatocyte nuclei of mice with iron overload. Hepatology. 12:1990;1399-1405.
28. Carthew P, Edwards R, Smith A, Dorman B, Francis J. Rapid induction of hepatic fibrosis in the gerbil after the parenteral administration of iron-dextran complex. Hepatology. 13:1991;534-539.
29. Carthew P, Dorman BM, Edwards RE, Francis JE, Smith AG. A unique rodent model for both the cardiotoxic and hepatotoxic effects of prolonged iron overload. Lab Invest. 69:1993;217-222.
30. Feulgen R, Rossenberg H. Mikroskopisch-chemischer Nachweis einer Nucleinsäure von Typus der Thymonucleinsäure und die dorauf beruhende elektive Färbung von Zellkernen in mikroscopischen Präparaten. S Physiol Chem. 135:1924;203-248.
31. Barry M, Sherlock S. Measurement of liver-iron concentration in needle-biopsy specimens. Lancet. ii:1971;100-103.
32. Iancu TC. Iron overload. Mol Aspects Med. 6:1983;1-100.
33. Haddow A, Horning ES. On the carcinogenicity of an iron-dextran complex. J Natl Canc Inst. 24:1960;109-147.
34. Richter GW. Intranuclear aggregates of ferritin in liver cells of mice treated with saccharated iron oxide. J Biophys Biochem Cytol. 9:1961;263-270.
35. Prunescu CC, Prunescu P. Ferritin accumulation in nuclei of hepatocytes in polymaltosed iron injected mice. Rev Roum Biochim. 28:1991;169-172.
36. Lanford RE, Kanda P, Kennedy RC. Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal. Cell. 46:1986;575-582.
37. Britton RS, Tavill AS, Bacon BR. Mechanisms of iron toxicity. Brock JH, Halliday JW, Pippard MJ, Powell LW, . Iron Metabolism in Health and Disease. 1994;312-351 Saunders Company Ltds, London.
38. Kukielka E, Cederbaum AI. Ferritin stimulation of Hydroxyl radical production by rat liver nuclei. Arch Biochem Biophys. 308:1994;70-77.
39. Bakker GR, Boyer RF. Iron incorporation into apoferritin. The role of apoferritin as a ferroxidase. J Biol Chem. 261:1986;13182-13185.
40. Deugnier YM, Charalambous P, Le Quilleuc D, Turlin B, Searle J, Brissot P, et al. Preneoplastic significance of hepatic iron-free foci in genetic hemochromatosis: a study of 185 patients. Hepatology. 18:1993;1363-1369.
41. Christie G, Lepage R. Enlargement of liver cells nuclei: effect of dimethylnitrosamine on size and deoxyribose nucleic acid content. Lab Invest. 10:1961;729-743.
42. Clawson GA, Blakenship LJ, Rhame JG, Wilkinson DS. Nuclear enlargement induced by hepatocarcinogens alters ploidy. Cancer Res. 52:1992;1304-1308.
43. Madra S, Styles J, Smith AG. Perturbation of hepatocyte nuclear populations induced by iron and polychlorinated biphenyls in C57BL/10SCSn mice during carcinogenesis. Carcinogenesis. 16:1995;719-727.
44. Smith AG, Cabral JRP, Carthew P, Francis JE, Manson MM. Carcinogenicity of iron in conjunction with a chlorinated environmental, hexachlorobenzene, in C57BL/10ScSn mice. Int J Cancer. 43:1989;492-496.
45. Smith AG, Francis JE, Carthew P. Iron as a synergist for hepatocellular carcinoma induced by polychorinated biphenyls in Ahresponsive C57BL/10ScSn mice. Carcinogenesis. 11:1990;437-444.
46. Carthew P, Nolan BM, Smith AG, Edwards RE. Iron promotes DEN initiated GST-foci in rat liver. Carcinogenesis. 18:1997;599-603.
47. Popper H. Pathological aspects of cirrhosis. Am J Pathol. 87:1977;228-258.
48. Fang JW, Bird GL, Nakamura T, Davis G L, Lau JY. Hepatocyte proliferation as an indicator of outcome in acute alcoholic hepatitis. Lancet. 343:1994;820-823.