In vitro activities of pyronaridine, alone and in combination with other antimalarial drugs, against Plasmodium falciparum

Antimicrobial Agents and Chemotherapy

Volumn 43, Issue 6, 1999, Pages 1525-1527

  Ringwald, Pascal ^a,b   Eboumbou, Else Carole Moukoko ^a   Bickii, Jean ^a   Basco, Leonardo K ^a  

^a Inst Francais Rech Sci pour le D   (Cameroon)

^b Organisation de Coordination pour la Lutte contre les Endemies en Afrique Centrale Cameroon   (Cameroon)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; ARTEMETHER; CHLOROQUINE; CYCLOGUANIL; DIHYDROARTEMISININ; HALOFANTRINE; MEFLOQUINE; PYRIMETHAMINE; PYRONARIDINE; QUININE;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG SCREENING; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

EID: 0032997429     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.43.6.1525     Document Type: Article

References (20)

1. Basco, L. K., and J. Le Bras. 1992. In vitro activity of pyronaridine against African strains of Plasmodium falciparum. Ann. Trop. Med. Parasitol. 86: 447-454.
2. Berenbaum, M. C. 1978. A method for testing for synergy with any number of agents. J. Infect. Dis. 137:122-130.
3. Canfield, C. J., M. Pudney, and W. E. Gutteridge. 1995. Interactions of atovaquone with other antimalarial drags against Plasmodium falciparum in vitro. Exp. Parasitol. 80:373-381.
4. Chen, C., L. H. Tang, and C. Jantanavivat. 1992. Studies on a new antimalarial compound: pyronaridine. Trans. R. Soc. Trop. Med. Hyg. 86:7-10.
5. Childs, G. E., B. Hausler, W. Milhous, C. Chen, T. Wimonwattrawatee, N. Pooyindee, and E. F. Boudreau. 1988. In vitro activity of pyronaridine against field isolates and reference clones of Plasmodium falciparum. Am. J. Trop. Med. Hyg. 38:24-29.
6. Desjardins, R. E., C. J. Canfield, J. D. Haynes, and J. D. Chulay. 1979. Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob. Agents Chemother. 16:710-718.
7. Elueze, E. I., S. L. Croft, and D. C. Warhurst. 1996. Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro. J. Antimicrob. Chemother. 37:511-518.
8. Lambros, C., and J. P. Vanderberg. 1979. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol. 65:418-420.
9. Liu, D. Q., R. J. Liu, C. Y. Zhang, X. Z. Cai, X. Tang, H. L. Yang, P. F. Yang, and Y. Dong. 1996. Present status of the sensitivity of Plasmodium falciparum to antimalarials in China. Chin. J. Parasitol. Parasit. Dis. 14:37-41.
10. Looareesuwan, S., D. E. Kyle, C. Viravan, S. Vanijanonta, P. Wilairatana, and W. H. Wernsdorfer. 1996. Clinical study of pyronaridine for the treatment of acute uncomplicated falciparum malaria in Thailand. Am. J. Trop. Med. Hyg. 54:205-209.
11. Peters, W., and B. L. Robinson. 1992. The chemotherapy of rodent malaria. XLVII. Studies on pyronaridine and other Mannich base antimalarials. Ann. Trop. Med. Parasitol. 86:455-465.
12. Peters, W., and B. L. Robinson. 1997. The chemotherapy of rodent malaria. LV. Interactions between pyronaridine and artemisinin. Ann. Trop. Med. Parasitol. 91:141-145.
13. Pradines, B., A. Tall, D. Parzy, A. Spiegel, T. Fusai, R. Hienne, J. F. Trape, and J. C. Doury. 1998. In-vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents. J. Antimicrob. Chemother. 42:333-339.
14. Ringwald, P., J. Bickii, and L. K. Basco. 1996. In vitro activity of antimalarials against clinical isolates of Plasmodium falciparum in Yaoundé, Cam-eroon. Am. J. Trop. Med. Hyg. 55:254-258.
15. Ringwald, P., J. Bickii, and L. Basco. 1996. Randomised trial of pyronaridine versus chloroquine for acute uncomplicated falciparum malaria in Africa. Lancet 347:24-28.
16. Ringwald, P., J. Bickii, and L. K. Basco. 1998. Efficacy of oral pyronaridine for the treatment of acute uncomplicated falciparum malaria in African children. Clin. Infect. Dis. 26:946-953.
17. Shao, B. R., X. Y. Ye, and Y. H. Chu. 1992. Comparison of effects of pyronaridine, amodiaquine, mefloquine and qinghaosu on rodent malaria. Southeast Asian J. Trop. Med. Public Health 23:59-63.
18. Warsame, M., W. H. Wernsdorfer, D. Payne, and A. Björkman. 1991. Positive relationship between the response of Plasmodium falciparum to chloroquine and pyronaridine. Trans. R. Soc. Trop. Med. Hyg. 85:570-571.
19. White, N. J., and P. L. Olliaro. 1996. Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol. Today 12:399-401.
20. Yang, H. L., D. Q. Liu, Y. M. Yang, K. G. Huang, Y. Dong, P. F. Yang, M. Z. Liao, and C. Y. Zhang. 1997. In vitro sensitivity of Plasmodium falciparum to eight antimalarials in China-Myanmar and China-Lao border areas. Southeast Asian J. Trop. Med. Public Health 28:460-464.