Off-resonance metabolite magnetization transfer measurements on rat brain in situ

Magnetic Resonance in Medicine

Volumn 41, Issue 6, 1999, Pages 1136-1144

  De Graaf, Robin A ^a   Van Kranenburg, Arnaud ^a   Nicolay, Klaas ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

1H MRS; Magnetization transfer; Metabolites; Off resonance saturation; Rat brain; Water suppression

Indexed keywords

BIOMOLECULES; CHEMICAL SHIFT; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RATS; SATURATION MAGNETIZATION;

MAGNETIZATION TRANSFER; OFF-RESONANCE; RAT BRAIN; WATER SUPPRESSION; ^1H MRS;

METABOLITES;

CREATINE; GLUTAMIC ACID; GLUTAMINE; N ACETYLASPARTIC ACID; WATER;

ARTICLE; BRAIN METABOLISM; MAGNET; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0032995507     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1522-2594(199906)41:6<1136::AID-MRM9>3.0.CO;2-G     Document Type: Article

References (28)

1. Forsen S, Hoffman RA. Study of moderately rapid chemical exchange reactions by means of nuclear magnetic double resonance. J Chem Phys 1964;39:2892-2901.
2. Ernst RR, Bodenhausen G, Wokaun A. Principles of nuclear magnetic resonance in one and two dimensions. Oxford: Clarendon Press; 1987.
3. Rudin M, Sauter A. Measurement of reaction rates in vivo using magnetization transfer techniques. In: Diehle P, Fluck E, Gunther H, Kosfeld R, Seelig J, editors. NMR basic principles and progress, vol 28. Berlin: Springer-Verlag; 1992. p 257-293.
4. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;19:135-144.
5. Metha RC, Pike GB, Enzemann DR. Improved detection of enhancing and nonenhancing lesions of multiple sclerosis with magnetization transfer. AJNR 1995;16:1771-1778.
6. Dreher W, Norris DG, Leibfritz D. Magnetization transfer affects the proton creatine/phosphocreatine signal intensity: in vivo demonstration in the rat brain. Magn Reson Med 1994;31:81-84.
7. Meyerhoff DJ, Rooney WD, Tokumitsu T, Weiner MW. Evidence of multiple ethanol pools in the brain: an in vivo proton magnetization transfer study. Alcoholism Clin Exp Res 1996;20:1283-1288.
8. Gruetter R, Luo Y, de Graaf RA, Terpstra M, Brooks D, Schleich T, Garwood M. Magnetization transfer to lactate methyl protons in rat C6 glioma in vivo. In: Proceedings of the ISMRM, 1995. p 110.
9. Luo Y, Rydzewski J, de Graaf RA, Gruetter R, Garwood M, Schleich T. In vivo observation of lactate methyl proton magnetization transfer in rat C6 glioma. Magn Reson Med 1999;41:676-685.
10. 1H-NMR signal of creatine/phosphocreatine from rat skeletal muscle shows a strong off-resonance magnetization transfer effect. MAGMA 1997;5(suppl):27.
11. 1H-MR signal from mouse skeletal muscle. In: Proceeings of the ISMRM, 1998. p 384.
12. Roell SA, Dreher W, Busch E, Leibfritz D. Magnetization transfer attenuates metabolite signals in tumorous and contralateral animal brain: in vivo observations by proton NMR spectroscopy. Magn Reson Med 1998;39:742-748.
13. Swanson SD. Lactic acid imaging via water proton magnetization. In: Proceedings of the ISMRM, 1997. p 1570.
14. Swanson SD. Protein mediated magnetic coupling between lactate and water protons. J Magn Reson 1998;135:248-255.
15. Guivel-Scharen V, Sinnwell T, Wolff SD, Balaban RS. Detection of proton chemical exchange between metabolites and water in biological tissues. J Magn Reson 1998;132:36-45.
16. Bottomley PA. Spatial localization in NMR spectroscopy in vivo. Ann NY Acad Sci 1987;508:333-348.
17. Mao J, Mareci TH, Andrew ER. Experimental study of optimal selective 180° radiofrequency pulses. J Magn Reson 1988;79:1-10.
18. 1H NMR chemical shift selective (CHESS) imaging. Phys Med Biol 1985;30:341-344.
19. Mescher M, Tannus A, O'Neil Johnson M, Garwood M. Solvent suppression using selective echo dephasing. J Magn Reson A 1996;123:226-229.
20. 31P NMR signals using the variable projection method and prior knowledge. Magn Reson Med 1988;6:92-98.
21. 1H spectroscopic imaging data sets. NMR Biomed 1992;5:171-178.
22. 1H magnetic resonance spectroscopy. Magn Reson Med 1995;33:862-867.
23. Schleich T, Caines GH, Rydzewski JM. Off-resonance rotating frame spin-lattice relaxation. Theory, and in vivo MRS and MRI applications. In: Berliner A, Ruben J, editors. Biological magnetic resonance, vol 11. New York: Plenum Press; 1992. p 55-144.
24. 1H NMR studies of lactate-macromolecule interactions. In: Proceedings of the ISMRM, 1996. p 1165.
25. Caines GH, Schleich T, Rydzewski JM. Incorporation of magnetization transfer into the formalism for rotating-frame spin-lattice proton NMR relaxation in the presence of an off-resonance-irradiation field. J Magn Reson 1991;95:558-566.
26. Henkelman RM, Huang X, Xiang Q-S, Stanisz GJ, Swanson SD, Bronskill MJ. Quantitative interpretation of magnetization transfer. Magn Reson Med 1993;29:759-766.
27. Morrison C, Henkelman RM. A model for magnetization transfer in tissues. Magn Reson Med 1995;33:475-482.
28. 1H NMR visibility of lactate in different rat and human brain cells. NMR Biomed 1994;7:349-355.