High precursor level in maternal blood results from the alternate mode of proopiomelanocortin processing in human placenta

Clinical Endocrinology

Volumn 50, Issue 1, 1999, Pages 85-94

  Raffin Sanson, Marie Laure ^a,f   Massias, Jean Francis ^a   Ankotche, Amos ^a   Coste, Joël ^b   De Keyzer, Yves ^a   Oliver, Charles ^d   Dumont, Chantal ^e   Cabrol, Dominique ^c   Ferré, Francoise ^d   Bertagna, Xavier ^a  

^a CNRS   (France)

^b HÔpital Bichat   (France)

^c Maternité Port Royal ^*  (France)

^d INSERM   (France)

^e Nichols Institute Diagnosis   (France)

^f INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID; HORMONE PRECURSOR; HYDROCORTISONE; PROOPIOMELANOCORTIN;

ADULT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; CORTICOTROPIN BLOOD LEVEL; FEMALE; HORMONE BLOOD LEVEL; HORMONE DETERMINATION; HORMONE INHIBITION; HORMONE RELEASE; HORMONE SYNTHESIS; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOPHYSIS FUNCTION; MAJOR CLINICAL STUDY; MATERNAL BLOOD; PEPTIDE ANALYSIS; PLACENTA FUNCTION; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; RNA ANALYSIS;

ADRENOCORTICOTROPIC HORMONE; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CORTICOTROPIN-RELEASING HORMONE; FEMALE; HUMANS; HYDROCORTISONE; IMMUNORADIOMETRIC ASSAY; PLACENTA; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY, MULTIPLE; PRO-OPIOMELANOCORTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 0032995014     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1999.00612.x     Document Type: Article

References (47)

1. Abou-Samra, A.B., Pugeat, M., Dechaud, H., Nachury, L., Bouchareb, B., Fevre-Montagne, M. & Toumiaire, J. (1984) Increased plasma concentration of N-terminal lipotrophin and unbound cortisol during pregnancy. Clinical Endocrinology, 20, 221-228.
2. Allolio, B., Hoffman, J., Linton, E.A., Winkelman, W., Kushe, M. & Schulle, H.M. (1990) Diurnal salivary cortisol patterns during pregnancy and after delivery: relationship to plasma corticotropin releasing hormone. Clinical Endocrinology, 33, 279-289.
3. Barnea, E.R., Lavy, G., Fakih, H. & De Cherney, A.H. (1986) The role of ACTH in steroidogenesis. Placenta, 7, 307-313.
4. Benjannet, S., Rondeau, N., Day, R., Chretien, M. & Seidah, N.G. (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proceedings of the National Academy of Sciences USA, 88, 3564-3568.
5. Bertagna, X., Nicholson, W.E., Peltengill, O.S., Sorenson, G.D., Mount, C.D. & Orth, D.N. (1978) Ectopic production of high molecular weight calcitonin and corticotropin by human small cell carcinoma cells in tissue culture: evidence for separate precursors. Journal of Clinical Endocrinology and Metabolism, 47, 1390-1393.
6. Bertagna, X., Lenne, F., Comar, D., Massias, J.F., Wajcman, H., Baudin, V., Luton, J.-P. & Girard, F. (1986) Human beta-melanocyte stimulating hormone revisited. Proceedings of the National Academy of Sciences USA, 83, 9719-9723.
7. Bertagna, X. (1994) Proopiomelanocortin-derived peptides. In: Endocrinology and Metabolism Clinics of North America: Cushing's syndrome (eds D. C. Aron & J. B. Tyrell). pp. 467-485. WB Saunders, New York.
8. Catanias, A.S. & Lipton, J.M. (1993) Alpha melanocyte stimulating hormone in the modulation of host reactions. Endocrinology Reviews, 14, 564-576.
9. Caraty, A., Grino, M., Locatelli, A., Guillaume, V., Boudourseque, F., Conte-Devolx, B. & Oliver, C. (1990) Insulin-induced hypoglycemia stimulates corticotropin-releasing factor and arginine vasopressin secretion into hypophysial portal blood of conscious unrestrained rams. Journal of Clinical Investigation, 85, 1716-1721.
10. Chen, C.L., Chang, C.C., Krieger, D.T. & Bardin, C.W. (1986) Expression and regulation of the proopimnelanocortin like gene in ovary and placenta: comparison with the testis. Endocrinology, 118, 2382-2389.
11. Chevrier, D., Lemieux, E., Fyfe, M., Labonte, N., Zollinger, M., Bennett, H. & Crine, Ph. (1991) Production of monoclonal antibodies against the N-terminal glycopeptide of procine proopiomelanocortin: their use for solid-phase radio-immunoassay, western blotting and immunogold cytochemistry. Biochemistry and Cell Biology 69, 58-65.
12. Clark, A.J.L., Lavender, P.M., Coates, P., Johnson, M.R. & Rees, L.H. (1990) In vitro and in vivo analysis of the processing and fate of the peptide products of the short proopiomelanocortin mRNA. Molecular Endocrinology, 4, 1737-1743.
13. Clifton, V.L., Read, M.A., Boura, A.L.A., Robinson, P.J. & Smith, R. (1996) Adrenocorticotropin causes vasodilatation in the human fetal-placental circulation. Journal of Clinical Endocrinology and Metabolism, 81, 1406-1410.
14. fat mice. Cell, 88, 73-83.
15. Crosby, S.R., Stewart, M.F., Ratcliffe, J.G. & White, A. (1988) Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay. Journal of Clinical Endocrinology and Metabolism, 67, 1272-1277.
16. Eipper, B.A. & Mains, R.E. (1980) Structure and biosynthesis of pro-adrenocorticotrophin/endorphin and related peptides. Endocrinology Review, 1, 1-27.
17. Frim, D.M., Emanuel, L., Robinson, B.G., Smas, C.D., Alder, G.K. & Majzoub, J.A. (1988) Characterization and gestational regulation of corticotrphin releasing factor messenger RNA in human placenta. Journal of Clinical Investigation, 82, 287-292.
18. Fuller, P.J, Lim, A.T.W, Barlow, J.W., White, E.L., Khalid, B.A., Copolov, D.L., Lolait, S., Funder, J.W. & Stockrigt, J.R. (1984) A pituitary tumor producing high molecular weight adrenocorticotropin-related peptides: clinical and cell culture studies. Journal of Clinical Endocrinology and Metabolism, 58, 134-142.
19. Gibson, S., Crosby, S., Stewart, M.F., Jennings, A.M., McCall, E. & White, A. (1994) Differential release of proopiomelanocortin-derived peptides from the human pituitary: evidence from a panel of two site immunoradiometric assays. Journal of Clinical Endocrinology and Metabolism, 78, 835-841.
20. Grino, M., Chrousos, G.P. & Margioris, A.N. (1987) The corticotropin releasing hormone gene is expressed in human placenta. Biochemical and Biophysical Research Communications, 148, 1208-1214.
21. Hale, A.C., Millar, J.B., Ratter, S.J., Pickard, J.D., Doniach, I. & Rees, L.H. (1985) A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. Clinical Endocrinology, 22, 479-488.
22. Lacaze-Masmonteil, T., De Keyzer, Y., Luton, J.-P., Kahn, A. & Bertagna, X. (1987) Characterization of proopiomelanocortin transcripts in human non-pituitary tissues. Proceedings of the National Academy of Sciences USA, 84, 7261-7265.
23. Landis, R.J., Heyman, E.R. & Koch, G.G. (1978) Average partial association in three-way contingency tables. A review and discussion of alternative tests. International Statistical Review, 46, 237-254.
24. Laudat, M.H., Guilhaume, B., Blot, P., Fournier, C., Giauque, J.P. & Luton, J.-P. (1987) Etat hormonal de la grossesse: modification du cortisol et de la testostérone. Annales d'Endocrinologie, 43, 334-338.
25. Laudat, M.H., Cerdas, S., Fournier, C., Guiban, D., Guilhaume, B. & Luton, J.-P. (1988) Salivary cortisol measurement: a practical approach to assess pituitary-adrenal function. Journal of Clinical Endocrinology and Metabolism, 66, 343-348.
26. Linton, E.A., McLean, C, Nieuwenhuyzen Kruseman, A.C., Tilders, F.J., Van Der Veen, E.A. & Lowry, P.J. (1987) Direct measurement of human plasma corticotropin releasing hormone by two-site immunoradiometric assay. Journal of Clinical Endocrinology and Metabolism, 64, 1047-1053.
27. Liotta, A.S., Osathamondh, R., Ryan, K.J. & Krieger, D.T. (1977) Presence of corticotropin in human placenta: demonstration of in vitro synthesis. Endocrinology, 101, 1552-1558.
28. Liotta, A.S., Houghten, R. & Krieger, D.T. (1982) Identification of a β-endorphin-like peptide in cultured human placental cells. Nature, 295, 593-595.
29. Liotta, A.S. & Krieger, D.T. (1980) In vitro biosynthesis and comparative post translational processing of immunoreactive precursor corticotropin/β endorphin by human placental and pituitary cells. Endocrinology. 106, 1504-1511.
30. McLean, M., Bisits, A., Davies, J., Woods, R., Lowry, P.J. & Smith, R. (1995) A placental clock controlling the length of human pregnancy. Nature Medicine, 1, 460-463.
31. Natori, S. & Huttner, W.B. (1996) Chromogranin B (secretogranin I) promotes sorting to the regulated secretory, pathway of processing intermediates derives from a peptide hormone precursor. Proceedings of the National Academy of Sciences USA, 93, 4431-4436.
32. Noel, G. & Mains, R.E. (1991) Plasticity of peptide biosynthesis in corticotropes: independent regulation of different steps in processing. Endocrinology, 129, 1317-1325.
33. Odagiri, E., Syerrell, N.J., Mount, C.D., Nicholson, W.E. & Orth, D.N. (1979) Human placental immuno-reactive corticotropin, lipotropin and β endorphin. Evidence for a common precursor. Proceedings of the National Academy of Sciences USA, 76, 2027-2030.
34. Orth, D.N., Nicholson, W.E., Mitchell, W.M., Island, D.P. & Liddle, G.A. (1973) Biologic and immunologic characterization and physical separation of ACTH and ACTH fragments in the ectopic ACTH syndrome. Journal of Clinical Investigation, 52, 1756-1769.
35. Petraglia, F., Sawchenico, J., Rivier, C. & Vale, W. (1987) Evidence for local stimulation of ACTH secretion by corticotrophin-releasing factor in human placenta. Nature, 328, 717-719.
36. Petraglia, F., Volpe, A., Genazzani, AR., Rivier, J., Sawchenko, P.E. & Vale, W. (1990) Neuroendocrinology of the human placenta. Frontiers in Neuroendocrinology, 11, 6-37.
37. Raffin-Sanson, M.-L., Massias, J.F., Dumont, C., Raux-Demay, M.C., Proeschel, M.F., Luton, J.P. & Bertagna, X. (1996) High plasma proopiomelanocortin in aggressive ACTH-secreting tumors. Journal of Clinical Endocrinology and Metabolism, 81, 4272-4277.
38. Ratter, S.J., Gillies, G., Hope, H., Hale, A.C., Grossman, A., Gaillard, R., Edwards, C.R.W. & Rees, L.H. (1983) Pro-opiocortin related peptides in human pituitary and ectopic ACTH tumors. Clinical Endocrinology, 18, 211-218.
39. Rees, L.H., Burke, C.W., Chard, T., Evans, S.W. & Letchworth, A.T. (1975) Possible placental origin of ACTH in normal human pregnancy. Nature, 234, 620-622.
40. SAS Institute Inc. User's guide (1989) Version 6, fourth edition, vol. 1, p. 874. SAS Institute Inc., Cary, NC.
41. Sasaki, A., Liotta, A.S., Luckey, M.M., Margioris, A.N., Suda, T. & Krieger, D.T. (1984) Immunoreactive corticotropin-releasing factor is present in human maternal plasma during the third trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism, 59, 812-814.
42. Schwartz, J., Kleflogiannis, F., Jacobs, R., Thorburn, D., Crosby, S.R. & White, A. (1995) Biological activity of adrenocorticotropic hormone precursor on ovine adrenal cells. American Journal of Physiology, 268, E623-E629.
43. Seidah, N.G., Gaspar, L., Mion, P., Marcinkiewicz, M., Mbikay, M. & Chrétien, M. (1990) cDNA sequence of two distinct pituitary proteins homologous to Kex2 and Furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA and Cell Biology, 9, 415-424.
44. Seidah, N.G., Marcinkiewicz, M. Benjannet, S., Gaspar, L., Beaubien, G., Mattei, M.G., Lazure, C., Mbikay, M. & Chretien, M. (1991) Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Molecular Endocrinology, 5, 111-122.
45. Siler-Khodr, T.M., Kang, I.A. & Khodr, G.S. (1991) Current topic: symposium on placental endocrinology. Effects of chorionic GnRH on intrauterine tissues and pregnancy. Placenta, 12, 91-103.
46. Stewart, P.M., Gibson, S., Crosby, S.R., Penn, R., Holder, R., Ferry, D., Thatcher, N., Phillips, P., London, D.R. & White, A. (1994) ACTH precursors characterize the ectopic ACTH syndrome. Clinical Endocrinology, 40, 199-204.
47. Vicau, D., Massias, J.F., Girard, F., Luton, J.-P. & Bertagna, X. (1989) Corticotrophin-like intermediary lobe peptide as a marker of alternate proopiomelanocortin processing in ACTH-producing nonpituitary tumours. Clinical Endocrinology, 31, 691-700.