Enhanced chemical stability of the intracellular prodrug, 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine, relative to its parent compound, cidofovir

International Journal of Pharmaceutics

Volumn 179, Issue 2, 1999, Pages 257-265

  Oliyai, Reza ^a   Lee, William A ^a   Visor, Gary C ^b   Yuan, Lung Chi ^a  

^a GILEAD SCIENCES   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Chemical stability; Cidofovir; Cyclic HPMPC; Cytosine; Deamination; Prodrug

Indexed keywords

1 [(2 HYDROXY 2 OXO 1,4,2 DIOXAPHOSPHORINAN 5 YL)METHYL]CYTOSINE; CIDOFOVIR; CYTOSINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG DEGRADATION; DRUG DETERMINATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PH; PRIORITY JOURNAL;

ANTIVIRAL AGENTS; CYTOSINE; DRUG STABILITY; HYDROLYSIS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; PRODRUGS; SOLUBILITY;

EID: 0032994775     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00395-0     Document Type: Conference Paper

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